The Effect of ABO Blood Group on von Willebrand Response to Exercise

2007 ◽  
Vol 14 (4) ◽  
pp. 454-458 ◽  
Author(s):  
Jerri L. Ribeiro ◽  
Gabriele D. Salton ◽  
Eliane Bandinelli ◽  
Alvaro R. Oliveira ◽  
Israel Roisenberg
Keyword(s):  
Blood Group ◽  
Ventilatory Threshold ◽  
Thromboembolic Disease ◽  
Maximal Heart Rate ◽  
Venous Thromboembolic Disease ◽  
Lower Plasma ◽  
Venous Thromboembolic ◽  
Von Willebrand ◽  
Response To Exercise ◽  
Willebrand Factor

Individuals of O blood group have significantly lower plasma levels of either Factor VIII (FVIII) or the von Willebrand factor (vWF). Conversely, there is accumulating evidence that elevated FVIII—vWF levels may represent an important risk factor for ischemic heart and venous thromboembolic disease. In this study, individuals exercised for 20 minutes at 10% below the first ventilatory threshold (aerobic threshold), which corresponds to 48% of maximum oxygen uptake. People with non-O blood group show higher resting and postexercise vWF levels compared with those of O blood group, as evidenced by a lower maximal heart rate. The groups were compared using the ANOVA one-way test, and a P < 0.05 was considered statistically significant. These results could change the way in which exercise training is designed for both healthy and sick individuals because O group individuals could have a more thrombogenic response to exercise.

Monitoring Heparin Therapy: Relationships between the Activated Partial Thromboplastin Time and Heparin Assays Based on Ex-Vivo Heparin Samples

1990 ◽  
Vol 63 (01) ◽  
pp. 016-023 ◽  
Author(s):  
A M H P van den Bessekaar ◽  
J Meeuwisse-Braun ◽  
R M Bertina
Keyword(s):  
Partial Thromboplastin Time ◽  
Plasma Sample ◽  
Ex Vivo ◽  
Correlation Coefficients ◽  
Heparin Therapy ◽  
Thromboembolic Disease ◽  
Activated Partial Thromboplastin Time ◽  
Venous Thromboembolic Disease ◽  
Venous Thromboembolic

SummaryFive different APTT reagents, two amidolytic anti-ITa assays, one amidoiytic anti-Xa assay, and one coagulometric anti-Xa/ anti-IIa assay were used to assess the effect of heparin in patients treated for venous thromboembolic disease. Good correlations were observed between lug-transformed APYE> determined with the various reagents (correlation coefficients: 0.92-0.96).Nevertheless there were important differences in the slopes of the lines of relationship between the APTT reagents.Good correlations were observed between the anti-Xa and anti-IIa assay results (correlation coefficients: 0.92-0.97). However, the amidolytic anti-Xa activity was significantly higher (p <0.001) than the two amidolytic anti-IIa activities. Less good correlations were observed between the log-transformed APTTs and the anti-Xa or anti-IIa activities (correlation coefficients: 0.64-0.78). The correlations were improved by transforming the APTT into APTT-ratio, i.e. the ratio of the patient’s APTT to the same patient’s APTT after removal of heparin from the plasma sample by means of ECTEOLA-cellulose treatment. The correlation coefficients of log (AFTT-ratio) with anti-Xa or anti-IIa ranged from 0.76 to 0.87.For both APTT and amidolytic heparin assay, the response to in vitro heparin was different from the response to ex vivo heparin.Therefore, equivalent therapeutic ranges should be assessed by using ex vivo samples rather than in vitro heparin. Because of the response differences between the APTT reagents, it is not adequate to define a therapeutic range for heparin therapy without specification of the reagent.

Periodontitis as A Risk Factor of Unprovoked Venous Thromboembolic Disease: An Emerging Association

2018 ◽  
Vol 2 (12) ◽  
Author(s):  
Nifosì Lorenzo ◽  
Zuccarello Mariateresa ◽  
Nifosì Antonio Fabrizio ◽  
Hervas Saus Vanessa ◽  
Nifosì Gianfilippo
Keyword(s):  
Risk Factor ◽  
Thromboembolic Disease ◽  
Venous Thromboembolic Disease ◽  
Venous Thromboembolic

Venous Thromboembolic Disease in Urological Practice

1959 ◽  
Vol 81 (1) ◽  
pp. 215-218 ◽  
Author(s):  
Earl P. Galleher ◽  
William G. Anlyan
Keyword(s):  
Thromboembolic Disease ◽  
Venous Thromboembolic Disease ◽  
Venous Thromboembolic
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