Amended Safety Assessment of Isethionate Salts as Used in Cosmetics

2017 ◽  
Vol 36 (1_suppl) ◽  
pp. 5S-16S
Author(s):  
Christina L. Burnett ◽  
Bart Heldreth ◽  
Wilma F. Bergfeld ◽  
Donald V. Belsito ◽  
Ronald A. Hill ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Clinical Data ◽  
Safety Assessment ◽  
Expert Panel ◽  
Core Structure ◽  
Cosmetic Products ◽  
Toxicological Data ◽  
Data Gaps

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) rereviewed the safety of 12 isethionate salts as used in cosmetics and concluded that these ingredients are safe in the present practices of use and concentration, when formulated to be nonirritating. These isethionate salts are reported to function mostly as surfactants and cleansing agents in cosmetic products. The Panel reviewed the available animal and clinical data as well as information from previous CIR reports. Although there are data gaps, the shared chemical core structure, expected similarities in physicochemical properties, and similar functions and concentrations in cosmetics enabled grouping these ingredients and reading across the available toxicological data to support the safety assessment of each ingredient.

scholarly journals Safety Assessment of Alkyl Betaines as Used in Cosmetics

2018 ◽  
Vol 37 (1_suppl) ◽  
pp. 28S-46S ◽  
Author(s):  
Christina L. Burnett ◽  
Wilma F. Bergfeld ◽  
Donald V. Belsito ◽  
Ronald A. Hill ◽  
Curtis D. Klaassen ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Safety Assessment ◽  
Expert Panel ◽  
Core Structure ◽  
Entire Group ◽  
Individual Compound ◽  
Cosmetic Products ◽  
Cosmetic Ingredients ◽  
Toxicological Data ◽  
Data Gaps

The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of 11 alkyl betaines as used in cosmetics. These ingredients are reported to function as hair and skin conditioning agents, antistatic agents, surfactants-cleansing agents, and viscosity-increasing agents in cosmetic products. Although there are data gaps, the shared chemical core structure, similar functions and concentrations of use in cosmetics, and the expected similarities in physicochemical properties enabled grouping these ingredients and reading across the available toxicological data to support the safety assessment of each individual compound in the entire group. The Panel concluded alkyl betaines were safe as cosmetic ingredients in the present practices of use and concentration, when formulated to be nonirritating.

Safety Assessment of Talc as Used in Cosmetics

2015 ◽  
Vol 34 (1_suppl) ◽  
pp. 66S-129S ◽  
Author(s):  
Monice M. Fiume ◽  
Ivan Boyer ◽  
Wilma F. Bergfeld ◽  
Donald V. Belsito ◽  
Ronald A. Hill ◽  
...  
Keyword(s):  
Clinical Data ◽  
Safety Assessment ◽  
Expert Panel ◽  
Cosmetic Products ◽  
Epidermal Barrier ◽  
The Subject ◽  
The Relationship

The Cosmetic Ingredient Review Expert Panel (Panel) assessed the safety of talc for use in cosmetics. The safety of talc has been the subject of much debate through the years, partly because the relationship between talc and asbestos is commonly misunderstood. Industry specifications state that cosmetic-grade talc must contain no detectable fibrous, asbestos minerals. Therefore, the large amount of available animal and clinical data the Panel relied on in assessing the safety of talc only included those studies on talc that did not contain asbestos. The Panel concluded that talc is safe for use in cosmetics in the present practices of use and concentration (some cosmetic products are entirely composed of talc). Talc should not be applied to the skin when the epidermal barrier is missing or significantly disrupted.

Safety Assessment of Ethanolamides as Used in Cosmetics

2015 ◽  
Vol 34 (1_suppl) ◽  
pp. 18S-34S ◽  
Author(s):  
Monice M. Fiume ◽  
Bart A. Heldreth ◽  
Wilma F. Bergfeld ◽  
Donald V. Belsito ◽  
Ronald A. Hill ◽  
...  
Keyword(s):  
Clinical Data ◽  
Safety Assessment ◽  
Expert Panel ◽  
Nitroso Compounds ◽  
Cosmetic Products

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) rereviewed the safety of 28 ethanolamides and found them safe in the present practices of use and concentration when they are formulated to be nonirritating, and that these ingredients should not be used in cosmetic products in which N-nitroso compounds may be formed. Most of the ethanolamides are reported to function in cosmetics as hair-conditioning agents, skin-conditioning agents, and surfactant—foam boosters. The Panel reviewed available animal and clinical data, as well as information from previous CIR reports.

Safety Assessment of Alkyl Glyceryl Ethers as Used in Cosmetics

2013 ◽  
Vol 32 (5_suppl) ◽  
pp. 5S-21S ◽  
Author(s):  
Wilbur Johnson ◽  
Wilma F. Bergfeld ◽  
Donald V. Belsito ◽  
Ronald A. Hill ◽  
Curtis D. Klaassen ◽  
...  
Keyword(s):  
Clinical Data ◽  
Safety Assessment ◽  
Expert Panel ◽  
Dermal Absorption ◽  
Cosmetic Products ◽  
Animal Toxicity

Alkyl glyceryl ethers function mostly as skin-conditioning agents in cosmetic products applied to the skin and hair. The Cosmetic Ingredient Review expert panel reviewed the available animal toxicity and clinical data, including the low dermal absorption, and concluded that the alkyl glyceryl ethers are safe in the present practices of use and concentration described in this safety assessment.

Safety Assessment of Triethanolamine and Triethanolamine-Containing Ingredients as Used in Cosmetics

2013 ◽  
Vol 32 (3_suppl) ◽  
pp. 59S-83S ◽  
Author(s):  
Monice M. Fiume ◽  
Bart Heldreth ◽  
Wilma F. Bergfeld ◽  
Donald V. Belsito ◽  
Ronald A. Hill ◽  
...  
Keyword(s):  
Clinical Data ◽  
Safety Assessment ◽  
Expert Panel ◽  
Nitroso Compounds ◽  
Cosmetic Products ◽  
Safety Assessments

The Cosmetic Ingredient Review Expert Panel assessed the safety of triethanolamine (TEA) and 31 related TEA-containing ingredients as used in cosmetics. The TEA is reported to function as a surfactant or pH adjuster; the related TEA-containing ingredients included in this safety assessment are reported to function as surfactants and hair- or skin-conditioning agents. The exception is TEA-sorbate, which is reported to function as a preservative. The Panel reviewed the available animal and clinical data. Although data were not available for all the ingredients, the panel relied on the information available for TEA in conjunction with previous safety assessments of components of TEA-containing ingredients. These data could be extrapolated to support the safety of all included ingredients. The panel concluded that TEA and related TEA-containing ingredients named in this report are safe as used when formulated to be nonirritating. These ingredients should not be used in cosmetic products in which N-nitroso compounds can be formed.

Safety Assessment of Isoparaffins as Used in Cosmetics

2012 ◽  
Vol 31 (6_suppl) ◽  
pp. 269S-295S ◽  
Author(s):  
Wilbur Johnson ◽  
Wilma F. Bergfeld ◽  
Donald V. Belsito ◽  
Ronald A. Hill ◽  
Curtis D. Klaassen ◽  
...  
Keyword(s):  
Clinical Data ◽  
Safety Assessment ◽  
Expert Panel ◽  
Cosmetic Products

The safety of isoparaffins as used in cosmetic products is reviewed in this safety assessment. These ingredients function mostly as solvents and also function as emollients in the 0001% to 90% concentration range. The Cosmetic Ingredient Review (CIR) Expert Panel has reviewed relevant animal and clinical data and concluded that these ingredients are safe in the present practices of use and concentration described in this safety assessment.

scholarly journals Safety Assessment of Polyether Lanolins as Used in Cosmetics

2018 ◽  
Vol 37 (1_suppl) ◽  
pp. 19S-27S
Author(s):  
Lillian C. Becker ◽  
Wilma F. Bergfeld ◽  
Donald V. Belsito ◽  
Ronald A. Hill ◽  
Curtis D. Klaassen ◽  
...  
Keyword(s):  
Clinical Data ◽  
Safety Assessment ◽  
Expert Panel ◽  
Entire Group ◽  
Toxicological Data ◽  
Safety Assessments ◽  
Structure Properties

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of 39 polyether lanolin ingredients as used in cosmetics. These ingredients function mostly as hair conditioning agents, skin conditioning agent—emollients, and surfactant—emulsifying agents. The Panel reviewed available animal and clinical data, from previous CIR safety assessments of related ingredients and components. The similar structure, properties, functions, and uses of these ingredients enabled grouping them and using the available toxicological data to assess the safety of the entire group. The Panel concluded that these polyether lanolin ingredients are safe in the practices of use and concentration as given in this safety assessment.

scholarly journals Safety Assessment of Alkyl Phosphates as Used in Cosmetics

2019 ◽  
Vol 38 (2_suppl) ◽  
pp. 12S-32S
Author(s):  
Monice M. Fiume ◽  
Wilma F. Bergfeld ◽  
Donald V. Belsito ◽  
Ronald A. Hill ◽  
Curtis D. Klaassen ◽  
...  
Keyword(s):  
Clinical Data ◽  
Safety Assessment ◽  
Expert Panel ◽  
Core Structure ◽  
Alkyl Chains ◽  
Cosmetic Ingredients ◽  
Alkyl Phosphate ◽  
Current Practices

The Expert Panel assessed the safety of 28 alkyl phosphates and concluded that these ingredients are safe in the current practices of use and concentration when formulated to be nonirritating. The ingredients in the alkyl phosphate family share a common phosphate core structure, and vary by the identity of the alkyl chains attached therein. Most of the alkyl phosphates function as surfactants in cosmetic ingredients; however, the triesters function as plasticizers rather than surfactants. The Panel reviewed the available animal and clinical data to determine the safety of these ingredients.

Safety Assessment of Alkyl Ethylhexanoates as Used in Cosmetics

2015 ◽  
Vol 34 (3_suppl) ◽  
pp. 61S-73S
Author(s):  
Monice Fiume ◽  
Bart Heldreth ◽  
Wilma F. Bergfeld ◽  
Donald V. Belsito ◽  
Ronald A. Hill ◽  
...  
Keyword(s):  
Clinical Data ◽  
Safety Assessment ◽  
Expert Panel ◽  
Entire Group ◽  
Toxicological Data ◽  
Cosmetic Formulations ◽  
Structure Properties

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of 16 alkyl ethylhexanoates for use in cosmetics, concluding that these ingredients are safe in cosmetic formulations in the present practices of use and concentrations when formulated to be nonirritating. The alkyl ethylhexanoates primarily function as skin-conditioning agents in cosmetics. The highest concentration of use reported for any of the alkyl ethylhexanoates is 77.3% cetyl ethylhexanoate in rinse-off formulations used near the eye, and the highest leave-on use reported is 52% cetyl ethylhexanoate in lipstick formulations. The Panel reviewed available animal and clinical data related to these ingredients, and the similarities in structure, properties, functions, and uses of ingredients from previous CIR assessments on constituent alcohols that allowed for extrapolation of the available toxicological data to assess the safety of the entire group.

Safety Assessment of Ethanolamine and Ethanolamine Salts as Used in Cosmetics

2015 ◽  
Vol 34 (2_suppl) ◽  
pp. 84S-98S ◽  
Author(s):  
Monice M. Fiume ◽  
Bart A. Heldreth ◽  
Wilma F. Bergfeld ◽  
Donald V. Belsito ◽  
Ronald A. Hill ◽  
...  
Keyword(s):  
Clinical Data ◽  
Safety Assessment ◽  
Expert Panel ◽  
Nitroso Compounds ◽  
Cosmetic Products

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of ethanolamine and 12 salts of ethanolamine as used in cosmetics. Ethanolamine functions as a pH adjuster. The majority of the salts are reported to function as surfactants, and the others are reported to function as pH adjusters, hair fixatives, or preservatives. The Panel reviewed available animal and clinical data, as well as information from previous relevant CIR reports. Because data were not available for each individual ingredient and because the salts dissociate freely in water, the Panel extrapolated from those previous reports to support safety. The Panel concluded that these ingredients are safe in the present practices of use and concentrations (rinse-off products only) when formulated to be nonirritating, and these ingredients should not be used in cosmetic products in which N-nitroso compounds may be formed.

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