Short-term effect of weight loss after bariatric surgery on IOP, RNFL thickness, and the optic nerve head blood flow measured by OCTA

Purpose: To study the influence of weight reduction after bariatric surgery on the intraocular pressure (IOP), retinal nerve fiber layer (RNFL) thickness, and blood flow of optic nerve head by optical coherence tomography angiography (OCTA). Methods: This prospective observational cohort study included 60 obese patients. Body mass index (BMI), IOP, RNFL, and ganglion cell complex (GCC) thickness, rim area, and radial peripapillary capillary (RPC) vessel density were assessed before and 3 months after bariatric surgery. Results: The BMI and the IOP showed significant postoperative reduction to 40.45 ± 4.3 kg/m2 and 14.83 ± 2.5 mmHg while the preoperative results were 51.13 ± 4.83 kg/m2 and 16.95 ± 4.2 mm ( p < 0.0001), respectively. No statistically significant change was detected in the RNFL, GCC thickness, rim area, or the RPC vessel density ( p > 0.05). No statistically significant correlation was detected between the BMI changes and changes in the IOP, RNFL thickness, rim area, GCC thickness, or RPC vessel density. Conclusion: No significant effect of bariatric surgery on the RNFL thickness and the optic nerve head blood flow measured by OCTA despite a significant IOP reduction 3 months post-surgical. OCTA can be a useful tool to assess the short-term influence of significant weight reduction on the retinal microcirculation. Summary: Despite a significant BMI and IOP reduction following bariatric surgery in obese patients, the vascular flow of the ONH, measured by OCTA, and the RNFL thickness were not significantly affected. The former might be attributed to the complex autoregulatory mechanisms related to the ONH and its microcirculation.

Download Full-text

Short-Term Increase of Intraocular Pressure Does Not Alter the Response of Retinal and Optic Nerve Head Blood Flow to Flicker Stimulation

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.04-1347 ◽

2005 ◽

Vol 46 (5) ◽

pp. 1721 ◽

Cited By ~ 22

Author(s):

Gerhard Garho¨fer ◽

Hemma Resch ◽

Gu¨nther Weigert ◽

Solveig Lung ◽

Christian Simader ◽

...

Keyword(s):

Blood Flow ◽

Intraocular Pressure ◽

Optic Nerve ◽

Optic Nerve Head ◽

Short Term ◽

Flicker Stimulation

Download Full-text

Increased Short-Term Fluctuation in Optic Nerve Head Blood Flow in a Case of Normal-Tension Glaucoma by the Use of Laser Speckle Flowgraphy

Vision ◽

10.3390/vision1010005 ◽

2016 ◽

Vol 1 (1) ◽

pp. 5

Author(s):

Tetsuya Sugiyama ◽

Hajime Nakamura

Keyword(s):

Blood Flow ◽

Optic Nerve ◽

Optic Nerve Head ◽

Normal Tension Glaucoma ◽

Laser Speckle ◽

Laser Speckle Flowgraphy ◽

Short Term ◽

Term Fluctuation

Download Full-text

Evaluation of the optic nerve head vessel density in patients with limited scleroderma

Therapeutic Advances in Ophthalmology ◽

10.1177/2515841421995387 ◽

2021 ◽

Vol 13 ◽

pp. 251584142199538

Author(s):

Hilal Kılınç Hekimsoy ◽

Ali Mehmet Şekeroğlu ◽

Ali Mert Koçer ◽

Vedat Hekimsoy ◽

Ali Akdoğan

Keyword(s):

Optical Coherence Tomography ◽

Optic Nerve ◽

Optic Nerve Head ◽

Vessel Density ◽

Optical Coherence ◽

Control Subjects ◽

Rnfl Thickness ◽

Significant Difference ◽

Healthy Control ◽

Limited Scleroderma

Objectives: To investigate the optical coherence tomography angiography (OCTA) parameters of the optic nerve head and peripapillary retina and to assess macular and peripapillary retinal nerve fiber layer (RNFL) thickness by using spectral-domain optical coherence tomography (SD-OCT) in patients with limited scleroderma and to compare these results with those of healthy control subjects. Materials and Methods: 42 patients with a confirmed diagnosis of limited scleroderma and 32 age- and sex-matched healthy control subjects were included in the study. OCTA was performed for the radial peripapillary capillary plexus (RPCP) whole image, inside disc, and peripapillary vessel densities in all participants with XR Avanti AngioVue OCTA (Optovue, Fremont, California, USA). OCT images were obtained with Spectralis OCT with eye-tracking dual-beam technology (Heidelberg Engineering GmbH, Heidelberg, Germany), and peripapillary RNFL thickness was evaluated with circle program. The data from the right eyes of all participants were used for statistical analysis. Results: No significant difference was found between the radial RPCP whole image, inside disc, and peripapillary vessel density values or the RNFL parameters of the scleroderma patients when compared with the controls ( p > 0.05 for all). Conclusion: Decreased peripapillary vessel density on OCTA, which can be an early sign of glaucoma, could not be observed in scleroderma patients in this study. However, further long-term studies are still needed to identify glaucoma tendency in patients with scleroderma before clinically detectable glaucoma.

Download Full-text

Direct and transsynaptic retrograde degeneration and optic nerve head microvascular changes in patients with hemianopia

European Journal of Ophthalmology ◽

10.1177/1120672120951731 ◽

2020 ◽

pp. 112067212095173

Author(s):

Tuna Celik Buyuktepe ◽

Pınar Bingöl Kızıltunç ◽

Murat Buyuktepe ◽

Huban Atilla

Keyword(s):

Optic Nerve ◽

Optic Nerve Head ◽

Vessel Density ◽

Ganglion Cell Complex ◽

Optic Coherence Tomography ◽

Fiber Layer ◽

Retrograde Degeneration ◽

Intracranial Lesion ◽

Microvascular Changes ◽

Contralateral Eye

Purpose: To investigate optic nerve head (ONH) microvascular changes secondary to transsynaptic retrograde degeneration (TRD), comperatively with direct retrograde degeneration and healthy controls. Methods: Patients with hemianopia due to intracranial lesion included in the study. Intracranial lesion was categorized by location: postgeniculate (causing TRD), chiasmal (causing direct retrograde degeneration). For the postgeniculate lesions, the eye on the same side of the lesion was defined as the ipsilateral eye and the eye on the opposite side as the contralateral eye. Optic disc microvasculature was evaluated with the help of optic coherence tomography angiography. Results: Sixteen eyes of 16 patients with chiasmal lesion, 28 eyes of 14 patients with postgeniculate lesion, and 30 eyes of 30 healthy subjects were included in the study. Ipsilateral eyes of the patients with postgeniculate lesion had decreased vessel density at the temporal sectors compatible with the affected nasal side of the visual field. Contralateral eyes showed no reduction of the vessel density at the affected nasal sectors. The eyes with chiasmal lesions had decreased vessel density at the peripapillary region and nasal half of the ONH compatible with temporal hemianopia. Vascular changes in the chiasmal lesion were more prominent than those of the postgeniculate lesion. Retinal nerve fiber layer and ganglion cell complex thickness were reduced. Conclusion: Vessel density of ONH was reduced in patients with homonymous hemianopia, providing evidence for TRD secondary to acquired postgeniculate lesion. Direct retrograde degeneration was more prominent in affected sectors when compared to TRD.

Download Full-text

Ocular Outcomes in Healthy Subjects Undergoing a Short-Term Head-Down Tilt Test

Aerospace Medicine and Human Performance ◽

10.3357/amhp.5804.2021 ◽

2021 ◽

Vol 92 (8) ◽

pp. 619-626

Author(s):

Bahadr zelbaykal ◽

Gkhan retmenolu ◽

. Hakk Tunez

Keyword(s):

Optic Nerve ◽

Optic Nerve Head ◽

Healthy Subjects ◽

Corneal Thickness ◽

Age Groups ◽

Vessel Density ◽

Tilt Test ◽

Short Term ◽

Disc Area ◽

Before And After

PURPOSE: This study aimed to examine the effect of head-down tilt (HDT) on vascular autoregulation in different age groups anddetermine its effects on intraocular pressure (IOP) and central corneal thickness (CCT).METHODS: Included were 43 eyes of 23 men. The optic nerve head and parafoveal vascular densities were measured by optical coherence tomography angiography before and after 20 min 10 HDT. Also, the study comprised an examination of theIOP and CCT in a subset of 8 participants (14 eyes) in the sitting position and during 15 min of 10 HDT.RESULTS: Grid-based inside disc all-vessel density (GBID) was statistically significantly lower after the HDT test in subjects under 30 yr (1.26). Whole image and peripapillary capillary vessel density (WICVD, PCVD), and whole image and peripapillary all-vessel density (WIAVD, PAVD) were significantly higher after the HDT test in subjects ages 3039 yr (1.34, 2.16, 1.05, 1.72, respectively). Inside disc capillary, all-vessel density (IDCVD, IDAVD) and GBID were significantly higher after HDT in subjects over 40 yr (2.48, 2.15, 1.52, respectively). In a subset of eight participants, IOP was significantly higher (3.7 mmHg) and CCT was unchanged after 15 min of HDT.CONCLUSION: Our study showed that simulated microgravity induced optic nerve head vessel density at the inside disc area, especially in persons over 40 years. In addition, IOP was increased by HDT, although no change in CCT was observed.zelbaykal B, retmenolu G, Tunez H. Ocular outcomes in healthy subjects undergoing a short-term head-down tilt test. Aerosp Med Hum Perform. 2021; 92(8):619626.

Download Full-text