Evaluation of optical coherence tomography findings in adolescents with genetic generalized epilepsy

Objective To evaluate retinal nerve fiber layer (RNFL) thickness, central macular thickness (CMT), and subfoveal choroid thickness (CT) by using optical coherence tomography (OCT) in adolescents with newly diagnosed epilepsy and patients who had been using Na valproate (VPA) for at least 1 year. Methods We examined 60 patients with genetic generalized epilepsy (GGE) aged 8–17 years. Thirty patients with newly diagnosed GGE who were evaluated before the beginning of the therapy and another 30 patients who were chosen from among adolescents with epilepsy using VPA for at least 1 year were included in the study. Results Nasal quadrant RNFL thickness and CMT measurements were significantly lower in the monotherapy group compared with the newly diagnosed group ( p = 0.044 and p = 0.032, respectively). CT measurements were not significantly different between the groups ( p = 0.413). There was a negative correlation in regression analysis between the duration of drug use and RNFL thickness in all quadrants. Conclusion According to our study, we observed thinning of the nasal RNFL and macular thickness in adolescents with epilepsy who were using Na valproate for at least 1 year and that as the duration of use increased, the thinning occurred in all RNFL quadrants. Further studies with larger series are needed to better understand the effects of both epilepsy and VPA on the eye.

Download Full-text

A Study of Retinal Nerve Fiber Layer Thickness by using Spectral Domain Optical Coherence Tomography in Older Adults with Diabetes Mellitus

10.35262/jiag.v15i1.17-21 ◽

2019 ◽

Vol 15 (1) ◽

pp. 17-21

Author(s):

Devendra Sharma ◽

Arvind Chauhan ◽

Avisha Mathur

Keyword(s):

Optical Coherence Tomography ◽

Diabetic Retinopathy ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Macular Thickness ◽

Spectral Domain ◽

Diabetic Patients ◽

Optical Coherence ◽

Fiber Layer ◽

Rnfl Thickness

Introduction: Peripapillary retinal nerve fiber layer (RNFL) thinning occurs in the diabetic patients earlier than the detectable diabetic retinopathy. We conducted this study to evaluate the RNFL thickness and macular thickness in elderly diabetic patients using optical coherence tomography in comparison to healthy controls. Material and methods: One fifty study participants were divided in 3 groups (50 each): normal subjects, patients with diabetes with no detectable diabetic retinopathy (NDR) and patients with diabetic retinopathy (DR) of differing severity. The RNFL thickness and macular thickness was measured using spectral-domain optical coherence tomography (SD OCT). Results: The RNFL thickness around the optic disc differed significantly among all the 3 groups and tended to become thinner as the patient develops DR in elderly subjects. The mean, superior-temporal and upper nasal peripapillary RNFL thickness differed among all the 3 groups. We observed that, mean superior, temporal, inferior and nasal RNFL tended to be thinner as the patient develops DR. Conclusion: The RNFL thickness, macular thickness and ganglion cell complex thinning differed significantly between the healthy group and diabetic group without clinical DR. The RNFL thinning (measured by Spectral-domain OCT) is an early neurodegenerative ocular change in diabetic patients even before onset of diabetic retinopathy.

Download Full-text

Normal Reference Ranges of Optical Coherence Tomography Parameters in Children

Folia Medica ◽

10.3897/folmed.62.e46678 ◽

2020 ◽

Vol 62 (2) ◽

pp. 338-344

Author(s):

Silviya Krumova ◽

Nelly Sivkova ◽

Vassil Marinov ◽

Desislava Koleva-Georgieva ◽

Desislava Voynikova

Keyword(s):

Optical Coherence Tomography ◽

Anterior Chamber ◽

Axial Length ◽

Anterior Chamber Depth ◽

Macular Thickness ◽

Reference Ranges ◽

Central Macular Thickness ◽

Optical Coherence ◽

Macular Volume ◽

Rnfl Thickness

Aim: To measure the macular thickness, macular volume and peripapillary retinal nerve fiber layer (RNFL) in healthy Caucasian children using spectral domain optical coherence tomography (SDOCT) and analyze the correlation of these values with age, refraction, and biometric measurements. Materials and methods: In this cross-sectional study, we recruited 270 healthy children (150 female and 120 male) aged 6 to 17 years with no ocular abnormalities. All children underwent a detailed eye examination. The measurements were obtained using a SDOCT device (SOCT Copernicus REVO). Main outcome measures were macular thickness, macular volume and RNFL thickness. Their correlations with age, refractive error, anterior chamber depth (ACD) and axial length (AL) was analyzed. Right eyes of all subjects were selected for analysis. Results: In this study group (mean age 10.70±2.82 years), the average peripapillary RNFL thickness was 117.11±9.15 μm, the central macular thickness was 232.10±15.81 μm, the average macular thickness was 286.70±9.82 μm, and the average macular volume was 8.01±0.28 mm³. The average values for the biometric data were: axial length – 23.16±0.94 mm, anterior chamber depth – 3.64±0.26 mm, the spherical equivalent (SE) value – +0.81±0.58 diopter. Central macular thickness, inner macular thickness (superior, inferior, nasal, temporal quadrants) values, total macular thickness and macular volume were significantly higher in males than in females. We found a positive correlation between central macular thickness, inner nasal macular thickness, outer inferior macular thickness values, and age. Also, we found a significant correlation between the average macular thickness values and the average macular volume values (p<0.0001). RNFL measurements did not correlate with age (p=0.199). Almost all macular parameters were consistently positively correlated with SE. A significant correlation was also found between the central macular thickness, inner inferior macular thickness, inner nasal macular thickness and the ACD. We found a significant correlation between the average macular thickness, macular volume, inner superior macular thickness, outer macular thickness (superior, inferior, nasal, temporal quadrants) values and the AL. Conclusion: This study found normal reference ranges for RNFL and macular parameters measured by SOCT Copernicus REVO in healthy Caucasian children aged 6-17 years. This normative values could be very useful in early diagnosing and monitoring of optic neuropathy, glaucoma and macular diseases in childhood.

Download Full-text

Changes in central Macular Thickness after Uncomplicated Phacoemulsification in Diabetic versus Non-Diabetic Patients using optical Coherence Tomography (OCT)

Sohag Medical Journal ◽

10.21608/smj.2018.40779 ◽

2018 ◽

Vol 22 (2) ◽

pp. 249-255

Author(s):

Ahmad Abd Allah ◽

Mohammad Mousa ◽

Marwa Abd Ellah ◽

Mohammed Hamed

Keyword(s):

Optical Coherence Tomography ◽

Macular Thickness ◽

Diabetic Patients ◽

Central Macular Thickness ◽

Optical Coherence

Download Full-text

Inter-relationship between retinal and choroidal vasculatures using optical coherence tomography angiography in normal eyes

European Journal of Ophthalmology ◽

10.1177/1120672118816225 ◽

2018 ◽

Vol 30 (1) ◽

pp. 48-57 ◽

Cited By ~ 5

Author(s):

Jaeryung Oh ◽

Daniel Jinhag Baik ◽

Jaemoon Ahn

Keyword(s):

Optical Coherence Tomography ◽

Layer Thickness ◽

Optical Coherence Tomography Angiography ◽

Macular Thickness ◽

Vascular Density ◽

Inner Plexiform Layer ◽

Central Macular Thickness ◽

Optical Coherence ◽

Outer Retina ◽

Capillary Plexus

Purpose: To quantify vascular and structural macular variables in healthy eyes and to investigate correlations between these variables and age using optical coherence tomography angiography. Materials and methods: A total of 261 eyes of 261 subjects with normal fundus were included. Central macular thickness, ganglion cell layer to inner plexiform layer thickness, outer retina layer thickness, subfoveal choroidal thickness, and choroidal vascularity index were measured using optical coherence tomography. Foveal avascular zone area, vascular density, and flow void area were measured using optical coherence tomography angiography. Results: Vascular density in the superficial capillary plexus was correlated with central macular thickness, ganglion cell layer to inner plexiform layer thickness, and outer retina layer thickness ( P < 0.001, P = 0.004, and P < 0.001, respectively). Vascular density in the deep capillary plexus was correlated with central macular thickness and outer retina layer thickness ( P = 0.003 and P = 0.001, respectively). Vascular density of choriocapillaris was correlated with vascular density of superficial capillary plexus and deep capillary plexus ( P < 0.001 and P = 0.001, respectively). Conclusion: Vascular density of choriocapillaris varies with retinal vascular density rather than the structure of choroid using optical coherence tomography angiography. In contrast, retinal vascular density changes as the retinal structure. Our results provide more information about the relationship between retina and choroid.

Download Full-text

Impact of Valsalva Maneuver on Central Choroid, Central Macula, and Disk Fiber Layer Thickness Among High Myopic and Hyperopic Patients

European Journal of Ophthalmology ◽

10.5301/ejo.5000834 ◽

2016 ◽

Vol 27 (3) ◽

pp. 331-335 ◽

Cited By ~ 1

Author(s):

Isil Kurultay-Ersan ◽

Sinan Emre

Keyword(s):

Axial Length ◽

Choroidal Thickness ◽

Valsalva Maneuver ◽

Significant Negative Correlation ◽

Macular Thickness ◽

Enhanced Depth Imaging ◽

Central Macular Thickness ◽

Fiber Layer ◽

Rnfl Thickness ◽

Before And After

Purpose To evaluate the alterations in mean central choroidal, central macular, and disk retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) during Valsalva maneuver among patients with high refractive errors. Methods A total of 60 high myopic (≥-6.0 D) and 50 high hyperopic (≥ + 3.0 D) eyes of 58 patients aged 19-65 years with visual acuity of 20/20 and without any ophthalmologic or systemic diseases were evaluated by OCT before and after the Valsalva maneuver. The choroidal thickness was measured with enhanced depth imaging OCT method. Central macular thickness, disk RNFL thickness, and axial length were also assessed. Results Mean choroidal thickness increased significantly from 275.0 ± 27.2 μm at rest to 279.8 ± 31.6 μm after Valsalva maneuver in high myopic patients, and from 308.2 ± 27.3 μm to 313.6 ± 28.5 μm in high hyperopic patients (p<0.01 for each). A significant negative correlation of the choroidal thickness was noted with axial length (r = -0.509, p<0.01) and age (r = -0.224, p = 0.01) in the overall study population. Mean central macular thickness was 242.9 ± 44.4 μm and 254.0 ± 22.8 μm, while mean disk RNFL thickness was 81.6 ± 12.4 μm and 98.4 ± 13.3 μm in high myopic and hyperopic patients, respectively. Valsalva maneuver was not associated with significant change in central macular or disk RNFL thickness. Conclusions Significant association of Valsalva maneuver with an increase in choroidal thickness was noted among patients with high degree of myopia and hyperopia. Our findings emphasize the likelihood of increase in choroidal volume due to venous distension to be responsible for the increase observed in choroidal thickness after Valsalva maneuver.

Download Full-text

Effect of diabetes on central macular thickness quantitatively measured using optical coherence tomography at Sidi-Hussein Health Center, Benghazi, Libya

Libyan International Medical University Journal ◽

10.4103/liuj.liuj_22_19 ◽

2019 ◽

Vol 4 (2) ◽

pp. 49

Author(s):

SamarA Bukhatwa ◽

MervatA Omear ◽

FatmaSaleh Benkhaial

Keyword(s):

Optical Coherence Tomography ◽

Health Center ◽

Macular Thickness ◽

Central Macular Thickness ◽

Optical Coherence

Download Full-text

DETERMINATION OF FACTORS ASSOCIATED WITH PERIPAPILLARY RETINAL NERVE FIBER LAYER AND MACULAR THICKNESS USING OPTICAL COHERENCE TOMOGRAPHY

Studies in Medical Sciences ◽

10.52547/umj.32.6.448 ◽

2021 ◽

Vol 32 (6) ◽

pp. 448-457

Author(s):

Hadi Ostadimoghaddam ◽

Neda Nakhjavanpour ◽

Abolfazl Payandeh ◽

Mohammad-Reza Mohammad-Reza Sedaghat ◽

◽

...

Keyword(s):

Optical Coherence Tomography ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Macular Thickness ◽

Optical Coherence ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Factors Associated ◽

Retinal Nerve Fiber

Download Full-text

Central Macular Thickness in a Healthy Mexican Population Using Huvitz Optical Coherence Tomography

Clinical Ophthalmology ◽

10.2147/opth.s272431 ◽

2020 ◽

Vol Volume 14 ◽

pp. 3931-3940

Author(s):

Renata García-Franco ◽

Dalia Méndez-Marín ◽

Marlon García-Roa ◽

Paulina Ramirez-Neria ◽

Diego Valera-Cornejo ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Macular Thickness ◽

Mexican Population ◽

Central Macular Thickness ◽

Optical Coherence

Download Full-text

Retinal Nerve Fiber Layer Imaging with Spectral-domain Optical Coherence Tomography (OCT)—A Review of the Cirrus HD-OCT

US Ophthalmic Review ◽

10.17925/usor.2011.04.01.12 ◽

2011 ◽

Vol 04 (01) ◽

pp. 12 ◽

Cited By ~ 1

Author(s):

Elaine To ◽

Dennis Lam ◽

Christopher Kai-shun Leung ◽

◽

...

Keyword(s):

Optical Coherence Tomography ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Spectral Domain ◽

Optical Coherence ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Spectral Domain Oct ◽

Rnfl Thickness ◽

Retinal Nerve Fiber

High-speed, high-resolution imaging of the retinal nerve fiber layer (RNFL) with spectral-domain optical coherence tomography (OCT) has become an essential tool for evaluation of glaucoma. The Cirrus HD-OCT (Carl Zeiss Meditec, Inc. Dublin, CA) is a spectral-domain OCT that provides visualization of the distribution pattern and measurement of RNFL abnormalities in a 6x6mm2optic disc region. Analysis of the RNFL thickness deviation map—a color-coded map displaying areas of RNFL abnormalities—detects glaucoma with high sensitivity and specificity. Trend analysis of average and sectorial RNFL thicknesses, and event analysis of the RNFL thickness maps and the RNFL thickness profiles can be used to detect and follow diffuse and focal RNFL progression. RNFL measurement with spectral-domain OCT could provide important information for use in formulating treatment plans and evaluating disease prognosis in the management of glaucoma.

Download Full-text