Multiple Cutaneous and Uterine Leiomyomas Associated with Gastric Gist

Background: There are a number of reports documenting familial cases of leiomyomatosis cutis associated with uterine leiomyomata. However, to our knowledge, the association of gastrointestinal stromal tumour (GIST) with this entity has not as yet been reported. We report an interesting case of cutaneous leiomyomatosis, metachronous uterine leiomyomata, and a gastric GIST in a 43-year-old woman. Observation: The patient had previously undergone two separate uterine myomectomies at ages 25 and 26 years, respectively, followed by a hysterectomy at 27 years. At 36 years she underwent partial gastrectomy for excision of GIST and this was followed by the development of extensive, symptomatic cutaneous leiomyomata at 43 years. In the report, we have documented histological, immunohistochemical and clinical observations and furthermore report on the therapeutic measures undertaken. Conclusion: We report an interesting association of cutaneous leiomyomatosis, uterine leiomyomas and GIST.

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DOG1 immunoreactivity in uterine leiomyosarcomas

Journal of Clinical Pathology ◽

10.1136/jclinpath-2012-201150 ◽

2012 ◽

Vol 66 (1) ◽

pp. 40-43 ◽

Cited By ~ 23

Author(s):

Shatrughan P Sah ◽

W Glenn McCluggage

Keyword(s):

Gastrointestinal Stromal Tumour ◽

Tumour Cells ◽

Uterine Leiomyomas ◽

Stromal Tumour ◽

Uterine Leiomyosarcoma ◽

Uterine Neoplasms ◽

Tumour Type ◽

Mesenchymal Neoplasms ◽

Diagnostic Confusion

AimsDOG1 is a recently described marker of gastrointestinal stromal tumour (GIST) which is considered to be extremely sensitive and, among mesenchymal neoplasms, quite specific for this tumour type. Following the identification of DOG1 immunoreactivity in a uterine leiomyosarcoma, we wished to ascertain how prevalent DOG1 immunoreactivity was in this tumour type.MethodsWe stained a series of uterine leiomyosarcomas (n=26) with DOG1 and with CD117 (c-kit), another marker of GIST. Staining with both markers was classified as negative, focal (<50% tumour cells positive) or diffuse (≥50% tumour cells positive).ResultsDOG1 immunoreactivity was present in seven of 26 (27%) leiomyosarcomas. Staining was focal in five cases and diffuse in two. CD117 was positive in three of 26 (11.5%) cases, two focal and one diffuse. Two cases were positive with DOG1 and CD117. One of five uterine leiomyomas was focally positive with DOG1, and one extrauterine pelvic leiomyoma was diffusely positive with this marker.ConclusionsSince GISTs have rarely been described as primary uterine neoplasms, the presence of DOG1 immunoreactivity in a uterine leiomyosarcoma may result in diagnostic confusion, and a panel of markers is necessary for diagnosis. Uterine leiomyosarcomas should be added to the list of mesenchymal neoplasms which may be DOG1 positive.

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Synchronous Epithelioid Stromal Tumour and Lipoma in the Stomach

Canadian Journal of Gastroenterology ◽

10.1155/2003/627090 ◽

2003 ◽

Vol 17 (6) ◽

pp. 374-375 ◽

Cited By ~ 8

Author(s):

Nabeel Al-Brahim ◽

Jasim Radhi ◽

John Gately

Keyword(s):

Carcinoid Tumour ◽

Case Reports ◽

Polypoid Lesion ◽

Gastrointestinal Stromal Tumour ◽

Partial Gastrectomy ◽

Stromal Tumour ◽

Resected Stomach ◽

Mesenchymal Tumors ◽

Distal Stomach ◽

First Case

An 82-year-old man presented with upper gastrointestinal bleeding. A polypoid lesion of the distal stomach with focal ulceration was seen at endoscopy. This was treated by a partial gastrectomy. The resected stomach contained two separate tumours near the pylorus: a gastrointestinal stromal tumour (GIST) and an adjacent lipoma. The literature includes case reports of synchronously occurring GIST and adenocarcinoma, GIST and mucosa-associated lymphoid tissue lymphoma and GIST and carcinoid tumour. Herein is the first case report of two distinct mesenchymal tumors coexisting in the stomach.

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Perioperative and Oncological Outcome of Laparoscopic Resection of Gastrointestinal Stromal Tumour (GIST) of the Stomach

Diagnostic and Therapeutic Endoscopy ◽

10.1155/2009/286138 ◽

2009 ◽

Vol 2009 ◽

pp. 1-7 ◽

Cited By ~ 18

Author(s):

Ulrich Ronellenfitsch ◽

Wilko Staiger ◽

Georg Kähler ◽

Philipp Ströbel ◽

Matthias Schwarzbach ◽

...

Keyword(s):

Laparoscopic Resection ◽

Gastrointestinal Stromal Tumour ◽

Operation Time ◽

Oncologic Outcome ◽

Oncological Outcome ◽

Stromal Tumour ◽

Perioperative Outcomes ◽

Gastric Gist ◽

Gastric Gists

Background. Surgery remains the only curative treatment for gastrointestinal stromal tumour (GIST). Resection needs to ensure tumour-free margins while lymphadenectomy is not required. Thus, partial gastric resection is the treatment of choice for small gastric GISTs. Evidence on whether performing resection laparoscopically compromises outcome is limited. Methods. We compiled patients undergoing laparoscopic resection of suspected gastric GIST between 2003 and 2007. Follow-up was performed to obtain information on tumour recurrence. Results. Laparoscopic resection with free margins was performed in 21/22 patients. Histology confirmed GIST in 17 cases, 4 tumours were benign neoplasms. Median operation time and postoperative stay for GIST patients were 130 (range 80–201) mins and 7 (range 5–95) days. Two patients experienced stapler line leakage necessitating surgical revision. After median follow-up of 18 (range 1–53) months, no recurrence occurred. Conclusions. Laparoscopic resection of gastric GISTs yields good perioperative outcomes. Oncologic outcome needs to be assessed with longer follow-up. For posterior lesions, special precaution is needed. Laparoscopic resection could become standard for circumscribed gastric GISTs if necessary precautions for oncological procedures are observed.

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