scholarly journals Synchronous Epithelioid Stromal Tumour and Lipoma in the Stomach

2003 ◽  
Vol 17 (6) ◽  
pp. 374-375 ◽  
Author(s):  
Nabeel Al-Brahim ◽  
Jasim Radhi ◽  
John Gately

An 82-year-old man presented with upper gastrointestinal bleeding. A polypoid lesion of the distal stomach with focal ulceration was seen at endoscopy. This was treated by a partial gastrectomy. The resected stomach contained two separate tumours near the pylorus: a gastrointestinal stromal tumour (GIST) and an adjacent lipoma. The literature includes case reports of synchronously occurring GIST and adenocarcinoma, GIST and mucosa-associated lymphoid tissue lymphoma and GIST and carcinoid tumour. Herein is the first case report of two distinct mesenchymal tumors coexisting in the stomach.

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Areen Abdulelah Murshid ◽  
Hatim Q. Al-Maghraby

Desmoid tumors (deep fibromatosis) of the mesentery are rare mesenchymal tumors. They are often misdiagnosed, especially with a previous history of resection for gastrointestinal stromal tumor (GIST). Immunohistochemistry can help differentiate between these two tumors. In this article, we present a case we had encountered: a Desmoid tumor developing in a patient with a history of GIST 3 years ago. It is the first case of GIST with subsequent development of Desmoid tumor to be reported in Saudi Arabia. We discuss the two entities of Desmoid tumor and GIST by comparing their definitions, clinical presentations, histological features, immunohistochemistry stains, molecular pathogenesis, prognosis, and treatment. We also discuss the relationship between GIST and the subsequent development of Desmoid tumors and compare our case with case reports in literature.


2010 ◽  
Vol 5 ◽  
pp. 297-300
Author(s):  
Konrad Zaręba ◽  
Zbigniew Kamocki ◽  
Joanna Hołody-Zaręba ◽  
Katarzyna Guzińska-Ustymowicz ◽  
Andrzej Kemona ◽  
...  

2018 ◽  
Vol 5 (2) ◽  
pp. 752
Author(s):  
Abhijeet Bagul ◽  
Nandhkishore Narwade ◽  
Sridevi Murali ◽  
Yashraj Shah

Gastrointestinal stromal tumours (GIST) account for less than 1% of gastrointestinal tumours, whereas Gastrointestinal autonomic nerve tumour (GANT) is a rare variant of gastrointestinal stromal tumour (GIST) and occurs at an estimated frequency of 1% of all malignant gastrointestinal tumours. We report the case of a 38-year old male which represents the rarity in the incidence of a Gastrointestinal Stromal tumour as well as the occurrence of a gastrointestinal autonomic nerve tumour together in the same patient which presented as a jejunal lump along with a terminal ileocecal intussusception. Multiple GISTs are associated with familial or hereditary syndromes are described only in few case reports whereas multiple sporadic GISTs have been rarely reported. This review aims to report the multiple sporadic occurrence of two types of GISTs as well as discuss highlight the features and prognosis of GANTs as surgeons and gastroenterologists are unaware of the existence of such an entity.


2005 ◽  
Vol 9 (6) ◽  
pp. 332-335
Author(s):  
Manisha Lamba ◽  
Shailendra Verma ◽  
Robert Prokopetz ◽  
Tadeusz A. Pierscianowski ◽  
Maha Jabi ◽  
...  

Background: There are a number of reports documenting familial cases of leiomyomatosis cutis associated with uterine leiomyomata. However, to our knowledge, the association of gastrointestinal stromal tumour (GIST) with this entity has not as yet been reported. We report an interesting case of cutaneous leiomyomatosis, metachronous uterine leiomyomata, and a gastric GIST in a 43-year-old woman. Observation: The patient had previously undergone two separate uterine myomectomies at ages 25 and 26 years, respectively, followed by a hysterectomy at 27 years. At 36 years she underwent partial gastrectomy for excision of GIST and this was followed by the development of extensive, symptomatic cutaneous leiomyomata at 43 years. In the report, we have documented histological, immunohistochemical and clinical observations and furthermore report on the therapeutic measures undertaken. Conclusion: We report an interesting association of cutaneous leiomyomatosis, uterine leiomyomas and GIST.


2020 ◽  
pp. 106689692096117
Author(s):  
Raima A. Memon ◽  
Carlos N. Prieto Granada ◽  
Chirag Patel ◽  
Upender Manne ◽  
Martin J. Heslin ◽  
...  

Sclerosing epithelioid fibrosarcoma (SEF) is a rare, aggressive soft-tissue tumor, commonly occurring in upper and lower extremities, the limb girdle, and the head and neck, which shows morphologic and molecular overlap with low-grade fibromyxoid sarcoma. For SEF in soft tissues, 100 case reports have been published. To our knowledge, the present case is the first to be reported in English literature for a primary SEF of the stomach with a rare FUS-CREM fusion. We report a case of gastric SEF in a 35-year-old female who presented with nonspecific symptoms, including night sweat, cough, and iron deficiency anemia for the past few months. Further workup showed, on computed tomography, a large, heterogeneously enhancing and centrally necrotic left upper quadrant mass, which measured approximately 8.4 cm. A laparoscopic partial gastrectomy with distal pancreatectomy and splenectomy was performed. Histological examination and immunohistochemical staining suggested the diagnosis of primary gastric SEF, which was later confirmed by sarcoma fusion panel showing FUS-CREM fusion. In this article, we report this first case of SEF in the stomach with a rare FUS-CREM fusion, which has been previously reported only once in SEFs of soft tissue.


Diagnostics ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 633
Author(s):  
Rabie E. Elshaer ◽  
Eid R. Elgammal ◽  
Amr M. Elmistekawy ◽  
Walaa A. Ghannam ◽  
Ahmed E. Elshamy ◽  
...  

Gastrointestinal stromal tumors (GISTs) are common mesenchymal tumors of the gastrointestinal tract (GIT), usually occur as a solitary neoplasm. Inflammatory florid polyp (IFP) is a solitary rare benign lesion of the gastrointestinal tract, mainly occur in the gastric antrum, whose atypical presentation can mimic GISTs or other malignant tumors, therefore the synchronous occurrence of GISTs and IFP is extremely rare. We had a case of a 58-year-old man that was presented with recurrent epigastric pain and recurrent melena. Upper endoscopic examination revealed a large polypoid antrum polyp measured 7 cm at greatest dimension with focal ulceration. Clinical and radiological features did not reach the definite diagnosis until histopathological evaluation with immunohistochemical analysis was performed. Surgical intervention is recommended and partial gastrectomy was done with wide resection margins. Histological examination revealed two distinct GISTs and IFP parts presenting a collision tumor that showed spindle and epitheloid cells consistent with GISTs with histological features of florid polyp showed a characteristic perivascular onion-skin arrangement of spindle cells with dense chronic inflammatory infiltrate including eosinophils and lymphocytes. Immunohistochemical studies have been done and revealed an association between GISTs and IFP. To the best of our knowledge, this is the first case of a collision tumor consisting of a GIST and an IFP arising in the stomach. In conclusion, the gastrointestinal stromal tumor is the comments mesenchymal tumor of GIT and IFP is a rare benign lesion of GIT therefore association between GIST and IFP as a collision tumor is extremely rare.


2003 ◽  
Vol 73 (3) ◽  
pp. 167-169 ◽  
Author(s):  
Ravi L. Huilgol ◽  
Christopher J. Young ◽  
Michael J. Solomon

2018 ◽  
Vol 100 (3) ◽  
pp. e46-e48
Author(s):  
Y Zhang ◽  
YJ Wang ◽  
CJ Lu ◽  
GM Shu ◽  
T Bai

We report a case of giant gastrointestinal stromal tumour of the stomach in a 71-year-old woman, with emphasis on its going through surgical resection. The physical examination and radiological findings revealed that a giant mass occupied most of the abdominal cavity. The patient underwent an en-block resection of the mass, partial resection of the distal stomach and Billroth II gastrojejunostomy. The pathological diagnosis was gastrointestinal stromal tumour. The patient had a long-term disease-free survival. We emphasise that complete surgical resection is the only effective radical treatment approach for giant gastrointestinal stroma of the stomach. In some cases, we still have the opportunity for resection of these tumours because of their expansive growth, even though the lesions are very large.


Pathology ◽  
2014 ◽  
Vol 46 ◽  
pp. S111-S112
Author(s):  
Mahtab Farzin ◽  
Parag Sharma ◽  
Timothy Teo ◽  
Robert Eckstein ◽  
Bryn Atmore

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Toru Takagi ◽  
Shin Saito ◽  
Shinichiro Yokota ◽  
Yuki Kaneko ◽  
Kazuya Takahashi ◽  
...  

Abstract Background Leiomyosarcoma is a rare tumor that could originate from the gastrointestinal tract, uterus, kidney, retroperitoneum, and the soft tissues of the extremities. It accounts for only 1% of all gastrointestinal mesenchymal tumors and primary leiomyosarcoma of the stomach is extremely rare. Most cases reported as leiomyosarcoma of the stomach before the development of KIT immunohistochemistry might be gastrointestinal stromal tumors (GISTs) of the stomach and only 18 cases of leiomyosarcoma of the stomach have been reported since early 2000s. We report here a patient with leiomyosarcoma of the stomach treated by laparoscopic and endoscopic cooperative surgery (LECS). Case presentation A 59-year-old man was referred to our hospital for an early gastric cancer, which was initially treated by endoscopic submucosal dissection. Six months after his initial treatment, a follow-up esophagogastroduodenoscopy revealed a small polypoid lesion at the lesser curvature of the proximal stomach, which appeared to be a hyperplastic polyp. However, one and a half years later, the lesion grew and showed more irregular surface. Biopsy at the time revealed smooth muscle cell proliferation suggestive of leiomyoma. Three years later, the lesion grew even larger and biopsy showed pleomorphic spindle cells. Immunohistochemical study showed positive staining for alpha-smooth muscle actin and desmin, but negative for c-kit and CD34. Ki-67 labeling index was nearly 60%. Based on these findings, the diagnosis of leiomyosarcoma was established. The patient subsequently underwent a partial gastrectomy by LECS. The patient is currently in good condition without recurrence or metastasis at 12 months after surgery. Conclusions Leiomyosarcoma of the stomach is extremely rare. This is the first report of leiomyosarcoma of the stomach treated by LECS. We could also follow its appearance change through endoscopic examination for 3 years.


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