Sexual dysfunction and sympathetic skin response recorded from the genital region in women with multiple sclerosis

2007 ◽  
Vol 13 (6) ◽  
pp. 742-748 ◽  
Author(s):  
Yaprak Seçıl ◽  
Yeşim Yetımalar ◽  
Muhteşem Gedizlioğlu ◽  
Esra Arpaci ◽  
Figen Tokuçoğlu ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Sexual Dysfunction ◽  
Sympathetic Skin Response ◽  
Sexual Problems ◽  
Genital Region ◽  
Definite Multiple Sclerosis ◽  
Healthy Female ◽  
Skin Response ◽  
Group A ◽  
Multiple Sclerosis Patients

Multiple Sclerosis is known to cause autonomic and sexual dysfunction. However, genitourinary and sexual problems in female multiple sclerosis patients are difficult to analyse. Therefore, it is an understudied field. As an attempt to fill this gap, we evaluated genital region autonomic dysfunction of female multiple sclerosis patients by using genital sympathetic skin response. Forty female patients with definite multiple sclerosis and twenty healthy female controls were included in the study. We examined hand, foot and genital sympathetic skin responses. Some genitourinary parameters were questioned by and results were compared with genital sympathetic skin response results. Among multiple sclerosis patients 42.5% of them had genitourinary and 75% had sexual problems clinically. Sympathetic skin response pathologies were distributed as following: 22.5% in hand, 20% in the foot, and 50% in genital region in the patient group. A statistically significant correlation between sexual dysfunction and genital sympathetic skin response could not been found. It is found that patients with multiple sclerosis have higher genital sympathetic skin response abnormalities than foot and hand sympathetic skin response abnormalities. This might be the early sign of autonomic dysfuntion in multiple sclerosis patients. Genital sympathetic skin response may be an easy and objective method to apply and helpful to evaluate genitourinary dysfunction in women in conjunction with female sexual dysfuntion index. Multiple Sclerosis 2007; 13: 742-748. http://msj.sagepub.com

scholarly journals Anal sphincter dysfunction in multiple sclerosis: an observation manometric study

Open Medicine ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. 509-517 ◽  
Author(s):  
Silvia Marola ◽  
Alessia Ferrarese ◽  
Enrico Gibin ◽  
Marco Capobianco ◽  
Antonio Bertolotto ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Fecal Incontinence ◽  
Anal Pressure ◽  
Before And After ◽  
Group A ◽  
The Difference ◽  
Resting Anal Pressure ◽  
Group B ◽  
Multiple Sclerosis Patients ◽  
Group D

AbstractConstipation, obstructed defecation, and fecal incontinence are frequent complaints in multiple sclerosis. The literature on the pathophysiological mechanisms underlying these disorders is scant. Using anorectal manometry, we compared the anorectal function in patients with and without multiple sclerosis.136 patients referred from our Center for Multiple Sclerosis to the Coloproctology Outpatient Clinic, between January 2005 and December 2011, were enrolled. The patients were divided into four groups: multiple sclerosis patients with constipation (group A); multiple sclerosis patients with fecal incontinence (group B); non-multiple sclerosis patients with constipation (group C); non-multiple sclerosis patients with fecal incontinence (group D). Anorectal manometry was performed to measure: resting anal pressure; maximum squeeze pressure; rectoanal inhibitory reflex; filling pressure and urge pressure. The difference between resting anal pressure before and after maximum squeeze maneuvers was defined as the change in resting anal pressure calculated for each patient.ResultsGroup A patients were noted to have greater sphincter hypotonia at rest and during contraction compared with those in group C (p=0.02); the rectal sensitivity threshold was lower in group B than in group D patients (p=0.02). No voluntary postcontraction sphincter relaxation was observed in either group A or group B patients (p=0.891 and p=0.939, respectively).ConclusionsThe decrease in the difference in resting anal pressure before and after maximum squeeze maneuvers suggests post-contraction sphincter spasticity, indicating impaired pelvic floor coordination in multiple sclerosis patients. A knowledge of manometric alterations in such patients may be clinically relevant in the selection of patients for appropriate treatments and for planning targeted rehabilitation therapy.

Sympathetic skin response (SSR) is abnormal in multiple sclerosis

1995 ◽  
Vol 18 (2) ◽  
pp. 185-189 ◽  
Author(s):  
B. Elie ◽  
J. P. Loubo'Jtin
Keyword(s):  
Multiple Sclerosis ◽  
Sympathetic Skin Response ◽  
Skin Response

Prevalence of bladder, bowel and sexual problems among multiple sclerosis patients two to five years after diagnosis

2007 ◽  
Vol 13 (1) ◽  
pp. 106-112 ◽  
Author(s):  
M W Nortvedt ◽  
T Riise ◽  
J Frugaård ◽  
J Mohn ◽  
A Bakke ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Bowel Dysfunction ◽  
Sexual Problems ◽  
Health Related Quality ◽  
Related Quality ◽  
Bowel And Bladder Dysfunction ◽  
Health Related ◽  
Multiple Sclerosis Patients

Most multiple sclerosis (MS) patients experience some sexual, bladder and/or bowel dysfunction during the course of the disease - one of MS most disabling features. This study estimated the frequency of these problems among patients, two to five years after diagnosis, and investigated how these problems are associated with health-related quality of life (using the Multiple Sclerosis Quality of Life-54 questionnaire). The study population comprised a cohort of patients (n=56), diagnosed in a three-year period, in Hordaland County, Norway. The patients were examined clinically, including scoring of the Expanded Disability Status Scale (EDSS), and completed questionnaires related to bowel and bladder dysfunction, sexual problems and health-related quality of life. More than half the patients had bladder and sexual problems. The frequency of self-reported bladder problems corresponded to the relatively high levels of residual urine found. The presence of these problems was associated with lower scores on the quality of life scales. Further, the bowel problems reported were markedly associated with the quality of life scores. Since treatments and preventive strategies can manage many of these problems, we suggest increasing the focus on these aspects of the disease when consulting patients, including at early stages.

scholarly journals Sympathetic skin response in multiple sclerosis: a meta-analysis of case-control studies

2017 ◽  
Vol 39 (1) ◽  
pp. 45-52 ◽  
Author(s):  
Nicolò Margaritella ◽  
Laura Mendozzi ◽  
Massimo Garegnani ◽  
Elisabetta Gilardi ◽  
Raffaello Nemni ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Meta Analysis ◽  
Sympathetic Skin Response ◽  
Case Control ◽  
Case Control Studies ◽  
Skin Response

scholarly journals Time of interferon-β 1a injection and duration of treatment affect clinical side effects and acute changes of plasma hormone and cytokine levels in multiple sclerosis patients

2007 ◽  
Vol 13 (9) ◽  
pp. 1138-1145 ◽  
Author(s):  
T. Kümpfel ◽  
M. Schwan ◽  
Th. Pollmächer ◽  
A. Yassouridis ◽  
M. Uhr ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Side Effects ◽  
Time Course ◽  
Group A ◽  
Systemic Side Effects ◽  
Plasma Hormone ◽  
Group B ◽  
Acute Changes ◽  
Multiple Sclerosis Patients ◽  
Time Point

During initiation of interferon-beta (IFN-β) therapy, many multiple sclerosis (MS) patients experience systemic side effects which may depend on the time point of IFN-β injection. We investigated the time course of plasma hormone-, cytokine- and cytokine-receptor concentrations after the first injection of IFN-β either at 8.00 a.m. (group A) or at 6.00 p.m. (group B) and quantified clinical side effects within the first 9 h in 16 medication free patients with relapsing-remitting MS. This investigation was repeated after 6-month IFN-β therapy. Plasma ACTH and cortisol concentrations followed their physiological rhythms, with lower levels in the evening compared to the morning, but raised earlier and stronger in group B after IFN-β administration. IFN-β injection in the evening led to a prompter increase of plasma IL-6 concentrations and temperature during the first hours and correlated to more intense clinical side effects compared to group A. Plasma IL-10 concentrations increased more in group A compared to group B, but sTNF-RI and sTNF-RII concentrations raised 7 h after IFN-β injection only in group B. Acute effects on plasma hormone and cytokine concentrations adapted after 6-month IFN-β treatment, while diurnal variations were still present. Baseline sTNF-RII concentrations were elevated after 6-month IFN-β therapy only in group A. Our results show that time point of IFN-β injection has differential effects on acute changes of plasma hormone and cytokine concentrations and is related to systemic side effects. This may have implications on the tolerability and effectiveness of IFN-β therapy. Multiple Sclerosis 2007; 13: 1138—1145. http://msj.sagepub.com

scholarly journals Depression correlates with sexual dysfunction and fatigue in multiple sclerosis patients

2015 ◽  
Vol 357 ◽  
pp. e320-e321 ◽  
Author(s):  
G. Toncev ◽  
D. Mijailovic ◽  
S. Miletic Drakulic ◽  
T. Boskovic Matic ◽  
A. Gavrilovic ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Sexual Dysfunction ◽  
Multiple Sclerosis Patients
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