Wasted tongue in neuromyelitis optica spectrum disorders due to hypoglossal nerve involvement

2014 ◽  
Vol 21 (4) ◽  
pp. 488-491 ◽  
Author(s):  
Shanthi Viswanathan
Keyword(s):  
Differential Diagnosis ◽  
Neuromyelitis Optica ◽  
Hypoglossal Nerve ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Nerve Involvement ◽  
Spectrum Disorders

We report two cases of neuromyelitis optica spectrum disorder with hypoglossal nerve involvement resulting in a wasted tongue associated with other brainstem symptoms of hypogeusia, hypersalivation, hiccough, increased sweating, hyperemesis and myelitis (in the second patient). This occurred due to involvement of the hypoglossal, tractus solitarius and dorsal vagal nuclei. Though the myelitis and other brainstem signs recovered the hypoglossal nerve involvement resulting in a unilateral wasted tongue did not. It is important to consider neuromyelitis optica and its spectrum disorders in the differential diagnosis of a wasted tongue though its occurrence is rare.

Treatment options in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders

2021 ◽  
Vol 27 ◽  
Author(s):  
Paulus Rommer ◽  
Uwe K Zettl
Keyword(s):  
Multiple Sclerosis ◽  
Side Effects ◽  
Neuromyelitis Optica ◽  
Treatment Options ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
The Past ◽  
Drug Classes ◽  
Spectrum Disorders

: There are few diseases with as many therapeutic advances in recent years as in multiple sclerosis. Nine different drug classes with more than a dozen approved therapies are now available. Similarly, there have been unimaginable advances in understanding neuromyelitis optica (now neuromyelitis optica spectrum disorder [NMOSD]) over the past 15 years. Building on the knowledge gained, the first therapies have been approved in recent years. In this review, we aim to present all therapies approved for the treatment of MS or NMOSD. The different forms of application, different approval criteria and most important side effects will be presented. This work is intended for physicians who are interested in MS and NMOSD therapies and want to get a first overview and does not replace the respective guidelines of the regulatory authorities.

Neuromyelitis optica spectrum disorder mimicking extensive leukodystrophy

2018 ◽  
Vol 24 (9) ◽  
pp. 1256-1258 ◽  
Author(s):  
Jonathan Ciron ◽  
Olivier Colin ◽  
Marie-Pierre Rosier ◽  
Soline Lapeyrie ◽  
Damien Biotti ◽  
...  
Keyword(s):  
White Matter ◽  
Neuromyelitis Optica ◽  
Brain Mri ◽  
White Matter Lesions ◽  
Brain Lesions ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Spectrum Disorders

Brain MRI was originally considered to appear normal in neuromyelitis optica spectrum disorders (NMO-SD). Typical brain lesions are now well described and have been integrated in the latest revision of NMO-SD criteria, but the NMO-SD MRI pattern remains not yet comprehensive. We report here extensive white matter lesions (EWML) mimicking leukodystrophy in a 50-year-old woman with long-lasting anti-AQP4+ NMO-SD. We suggest that EWML could be a possible brain MRI presentation of NMO-SD patients.

scholarly journals Neuromyelitis Optica Spectrum Disorders: Spectrum of MR Imaging Findings and Their Differential Diagnosis—Erratum

Radiographics ◽  
2018 ◽  
Vol 38 (2) ◽  
pp. 662-662 ◽  
Author(s):  
Bruna Garbugio Dutra ◽  
Antônio José da Rocha ◽  
Renato Hoffmann Nunes ◽  
Antônio Carlos Martins Maia Júnior
Keyword(s):  
Differential Diagnosis ◽  
Mr Imaging ◽  
Neuromyelitis Optica ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Imaging Findings ◽  
Spectrum Disorders

Clinical Characteristics of Patients With Neuromyelitis Optica Spectrum Disorders With Early Onset

2019 ◽  
Vol 34 (9) ◽  
pp. 487-490 ◽  
Author(s):  
Yara Dadalti Fragoso ◽  
Nise Alessandra C. Sousa ◽  
Tania Saad ◽  
Soniza Vieira Alves-Leon ◽  
Maria Lucia V. Pimentel ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Medical Records ◽  
Early Onset ◽  
Disease Onset ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Retrospective Assessment ◽  
Initial Symptoms ◽  
Median Period ◽  
Spectrum Disorders

Neuromyelitis optica spectrum disorder is a severe and disabling disease that manifests with severe relapses of optic neuritis, longitudinally extensive myelitis, and/or brainstem syndromes. The disease is complex and, although onset typically occurs in middle age, children and adolescents may be affected. The present study adds to the literature through detailed clinical data from 36 Brazilian patients with neuromyelitis optica spectrum disorder starting before age 21. This was a retrospective assessment of medical records from 14 specialized units in Brazil. The results showed that the course of neuromyelitis optica spectrum disorder was worse in patients with disease onset before the age of 12 years. Gender and ethnic background did not influence disability accumulation. Over a median period of 8 years, 14% of the patients who presented the initial symptoms of neuromyelitis optica spectrum disorder before the age of 21 years died. In conclusion, the present study adds to the reports from other authors examining the severity of early-onset neuromyelitis optica spectrum disorder.

scholarly journals Neuromyelitis Optica Spectrum Disorders: Spectrum of MR Imaging Findings and Their Differential Diagnosis

Radiographics ◽  
2018 ◽  
Vol 38 (1) ◽  
pp. 169-193 ◽  
Author(s):  
Bruna Garbugio Dutra ◽  
Antônio José da Rocha ◽  
Renato Hoffmann Nunes ◽  
Antônio Carlos Martins Maia
Keyword(s):  
Differential Diagnosis ◽  
Mr Imaging ◽  
Neuromyelitis Optica ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Imaging Findings ◽  
Spectrum Disorders
Sign in / Sign up

Export Citation Format

Share Document