scholarly journals Regional patterns of grey matter atrophy and magnetisation transfer ratio abnormalities in multiple sclerosis clinical subgroups: A voxel-based analysis study

2014 ◽  
Vol 21 (4) ◽  
pp. 423-432 ◽  
Author(s):  
Shahrukh Mallik ◽  
Nils Muhlert ◽  
Rebecca S Samson ◽  
Varun Sethi ◽  
Claudia AM Wheeler-Kingshott ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Grey Matter ◽  
Axonal Loss ◽  
Magnetisation Transfer ◽  
Magnetisation Transfer Ratio ◽  
Regional Patterns ◽  
Transfer Ratio ◽  
Magnetic Resonance Imaging Mri ◽  
And Gender ◽  
Regional Localisation

Background: In multiple sclerosis (MS), demyelination and neuro-axonal loss occur in the brain grey matter (GM). We used magnetic resonance imaging (MRI) measures of GM magnetisation transfer ratio (MTR) and volume to assess the regional localisation of reduced MTR (reflecting demyelination) and atrophy (reflecting neuro-axonal loss) in relapsing–remitting MS (RRMS), secondary progressive MS (SPMS) and primary progressive MS (PPMS). Methods: A total of 98 people with MS (51 RRMS, 28 SPMS, 19 PPMS) and 29 controls had T1-weighted volumetric and magnetisation transfer scans. SPM8 was used to undertake voxel-based analysis (VBA) of GM tissue volumes and MTR. MS subgroups were compared with controls, adjusting for age and gender. A voxel-by-voxel basis correlation analysis between MTR and volume within each subject group was performed, using biological parametric mapping. Results: MTR reduction was more extensive than atrophy. RRMS and SPMS patients showed proportionately more atrophy in the deep GM. SPMS and PPMS patients showed proportionately greater cortical MTR reduction. RRMS patients demonstrated the most correlation of MTR reduction and atrophy in deep GM. In SPMS and PPMS patients, there was less extensive correlation. Conclusions: These results suggest that in the deep GM of RRMS patients, demyelination and neuro-axonal loss may be linked, while in SPMS and PPMS patients, neuro-axonal loss and demyelination may occur mostly independently.

REGIONAL PATTERNS OF GREY MATTER ATROPHY AND MAGNETISATION TRANSFER RATIO ABNORMALITIES IN MULTIPLE SCLEROSIS CLINICAL SUBGROUPS

2013 ◽  
Vol 84 (11) ◽  
pp. e2.94-e2
Author(s):  
Shahrukh Mallik ◽  
Nils Muhlert ◽  
Rebecca Samson ◽  
Claudia Wheeler–Kingshott ◽  
David Miller ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Grey Matter ◽  
Magnetisation Transfer ◽  
Magnetisation Transfer Ratio ◽  
Regional Patterns ◽  
Transfer Ratio ◽  
Grey Matter Atrophy

Magnetisation Transfer Ratio in Multiple Sclerosis: Axonal Loss or Demyelination?

2009 ◽  
Vol 16 (11) ◽  
pp. 1519
Author(s):  
Alexander Klistorner ◽  
Joga Rao ◽  
Raymond Garrick ◽  
Con Yiannikas
Keyword(s):  
Multiple Sclerosis ◽  
Axonal Loss ◽  
Magnetisation Transfer ◽  
Magnetisation Transfer Ratio ◽  
Transfer Ratio

Investigation of outer cortical magnetisation transfer ratio abnormalities in multiple sclerosis clinical subgroups

2014 ◽  
Vol 20 (10) ◽  
pp. 1322-1330 ◽  
Author(s):  
Rebecca S Samson ◽  
Manuel J Cardoso ◽  
Nils Muhlert ◽  
Varun Sethi ◽  
Claudia AM Wheeler-Kingshott ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Three Dimensional ◽  
Neuronal Loss ◽  
Magnetisation Transfer ◽  
Magnetisation Transfer Ratio ◽  
Outer Cortex ◽  
Transfer Ratio ◽  
Relapsing Remitting ◽  
Healthy Control

Background: Pathological abnormalities including demyelination and neuronal loss are reported in the outer cortex in multiple sclerosis (MS). Objective: We investigated for in vivo evidence of outer cortical abnormalities by measuring the magnetisation transfer ratio (MTR) in MS patients of different subgroups. Methods: Forty-four relapsing–remitting (RR) (mean age 41.9 years, median Expanded Disability Status Scale (EDSS) 2.0), 25 secondary progressive (SP) (54.1 years, EDSS 6.5) and 19 primary progressive (PP) (53.1 years, EDSS 6.0) MS patients and 35 healthy control subjects (mean age 39.2 years) were studied. Three-dimensional (3D) 1×1×1mm3 T1-weighted images and MTR data were acquired. The cortex was segmented, then subdivided into outer and inner bands, and MTR values were calculated for each band. Results: In a pairwise analysis, mean outer cortical MTR was lower than mean inner cortical MTR in all MS groups and controls ( p<0.001). Compared with controls, outer cortical MTR was decreased in SPMS ( p<0.001) and RRMS ( p<0.01), but not PPMS. Outer cortical MTR was lower in SPMS than PPMS ( p<0.01) and RRMS ( p<0.01). Conclusions: Lower outer than inner cortical MTR in healthy controls may reflect differences in myelin content. The lowest outer cortical MTR was seen in SPMS and is consistent with more extensive outer cortical (including subpial) pathology, such as demyelination and neuronal loss, as observed in post-mortem studies of SPMS patients.

Magnetisation transfer ratio in optic neuritis is associated with axonal loss, but not with demyelination

NeuroImage ◽  
2011 ◽  
Vol 56 (1) ◽  
pp. 21-26 ◽  
Author(s):  
A. Klistorner ◽  
J. Chaganti ◽  
R. Garrick ◽  
K. Moffat ◽  
C. Yiannikas
Keyword(s):  
Optic Neuritis ◽  
Axonal Loss ◽  
Magnetisation Transfer ◽  
Magnetisation Transfer Ratio ◽  
Transfer Ratio

Magnetisation transfer ratio measurement in the cervical spinal cord: a preliminary study in multiple sclerosis

1997 ◽  
Vol 39 (6) ◽  
pp. 441-445 ◽  
Author(s):  
N. C. Silver ◽  
G. J. Barker ◽  
N. A. Losseff ◽  
M. L. Gawne-Cain ◽  
D. G. MacManus ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Cervical Spinal Cord ◽  
Magnetisation Transfer ◽  
Magnetisation Transfer Ratio ◽  
Ratio Measurement ◽  
Transfer Ratio ◽  
Preliminary Study

scholarly journals Assessing Lumbar Plexus and Sciatic Nerve Damage in Relapsing-Remitting Multiple Sclerosis Using Magnetisation Transfer Ratio

2021 ◽  
Vol 12 ◽  
Author(s):  
Ratthaporn Boonsuth ◽  
Rebecca S. Samson ◽  
Carmen Tur ◽  
Marco Battiston ◽  
Francesco Grussu ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Nervous System ◽  
Magnetic Resonance ◽  
Sciatic Nerve ◽  
Lumbar Plexus ◽  
Imaging Biomarker ◽  
Magnetisation Transfer ◽  
Magnetisation Transfer Ratio ◽  
Transfer Ratio ◽  
Relapsing Remitting

Background: Multiple sclerosis (MS) has traditionally been regarded as a disease confined to the central nervous system (CNS). However, neuropathological, electrophysiological, and imaging studies have demonstrated that the peripheral nervous system (PNS) is also involved, with demyelination and, to a lesser extent, axonal degeneration representing the main pathophysiological mechanisms.Aim: The purpose of this study was to assess PNS damage at the lumbar plexus and sciatic nerve anatomical locations in people with relapsing-remitting MS (RRMS) and healthy controls (HCs) in vivo using magnetisation transfer ratio (MTR), which is a known imaging biomarker sensitive to alterations in myelin content in neural tissue, and not previously explored in the context of PNS damage in MS.Method: Eleven HCs (7 female, mean age 33.6 years, range 24-50) and 15 people with RRMS (12 female, mean age 38.5 years, range 30-56) were recruited for this study and underwent magnetic resonance imaging (MRI) investigations together with clinical assessments using the expanded disability status scale (EDSS). Magnetic resonance neurography (MRN) was first used for visualisation and identification of the lumbar plexus and the sciatic nerve and MTR imaging was subsequently performed using identical scan geometry to MRN, enabling straightforward co-registration of all data to obtain global and regional mean MTR measurements. Linear regression models were used to identify differences in MTR values between HCs and people with RRMS and to identify an association between MTR measures and EDSS.Results: MTR values in the sciatic nerve of people with RRMS were found to be significantly lower compared to HCs, but no significant MTR changes were identified in the lumbar plexus of people with RRMS. The median EDSS in people with RRMS was 2.0 (range, 0-3). No relationship between the MTR measures in the PNS and EDSS were identified at any of the anatomical locations studied in this cohort of people with RRMS.Conclusion: The results from this study demonstrate the presence of PNS damage in people with RRMS and support the notion that these changes, suggestive of demyelination, maybe occurring independently at different anatomical locations within the PNS. Further investigations to confirm these findings and to clarify the pathophysiological basis of these alterations are warranted.

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