Altered basal ganglia functional connectivity in multiple sclerosis patients with fatigue

2014 ◽  
Vol 21 (7) ◽  
pp. 925-934 ◽  
Author(s):  
C Finke ◽  
J Schlichting ◽  
S Papazoglou ◽  
M Scheel ◽  
A Freing ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Basal Ganglia ◽  
Functional Connectivity ◽  
Grey Matter ◽  
Matter Density ◽  
White Matter Integrity ◽  
Healthy Controls ◽  
Grey Matter Density ◽  
Fatigue Severity

Background: Fatigue is one of the most frequent and disabling symptoms in multiple sclerosis, but its pathophysiological mechanisms are poorly understood. It is in particular unclear whether and how fatigue relates to structural and functional brain changes. Objective: We aimed to analyse the association of fatigue severity with basal ganglia functional connectivity, basal ganglia volumes, white matter integrity and grey matter density. Methods: In 44 patients with relapsing–remitting multiple sclerosis and 20 age- and gender-matched healthy controls, resting-state fMRI, diffusion tensor imaging and voxel-based morphometry was performed. Results: In comparison with healthy controls, patients showed alteration of grey matter density, white matter integrity, basal ganglia volumes and basal ganglia functional connectivity. No association of fatigue severity with grey matter density, white matter integrity and basal ganglia volumes was observed within patients. In contrast, fatigue severity was negatively correlated with functional connectivity of basal ganglia nuclei with medial prefrontal cortex, precuneus and posterior cingulate cortex in patients. Furthermore, fatigue severity was positively correlated with functional connectivity between caudate nucleus and motor cortex. Conclusion: Fatigue is associated with distinct alterations of basal ganglia functional connectivity independent of overall disability. The pattern of connectivity changes suggests that disruption of motor and non-motor basal ganglia functions, including motivation and reward processing, contributes to fatigue pathophysiology in multiple sclerosis.

Decrease in basal ganglia grey matter density associated with atypical antipsychotic treatment in schizophrenia patients

2008 ◽  
Vol 103 (1-3) ◽  
pp. 319-321 ◽  
Author(s):  
Emmanuel Stip ◽  
Adham Mancini-Marïe ◽  
Cherine Fahim ◽  
Lahcen Ait Bentaleb ◽  
Genevieve Létourneau ◽  
...  
Keyword(s):  
Basal Ganglia ◽  
Atypical Antipsychotic ◽  
Grey Matter ◽  
Matter Density ◽  
Antipsychotic Treatment ◽  
Grey Matter Density

scholarly journals Erratum

2016 ◽  
Vol 22 (12) ◽  
pp. NP12-NP12
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Functional Connectivity ◽  
White Matter Integrity ◽  
Relapsing Remitting ◽  
John Radcliffe Hospital ◽  
Remitting Multiple Sclerosis ◽  
University Of Rome ◽  
Relapsing Remitting Multiple Sclerosis

Sbardella E, Tona F, Petsas N, et al. Functional connectivity changes and their relationship with clinical disability and white matter integrity in patients with relapsing–remitting multiple sclerosis. Multiple Sclerosis Journal 2015; 21(13): 1681–1692. DOI: 10.1177/1352458514568826 The above article that appeared in the November 2015 issue of Multiple Sclerosis Journal contained incorrect affiliations for two of the authors. The correct affiliation for Patrizia Pantano is Department of Neurology and Psychiatry, University of Rome, Italy / IRCSS Neuromed, Italy. The correct affiliation for Nicola Filippini is FMRIB Centre, John Radcliffe Hospital, UK.

scholarly journals White matter integrity and functional connectivity in adolescents with a parental history of substance use disorder

2021 ◽  
Vol 1 (3) ◽  
pp. 100037
Author(s):  
Xiaofu He ◽  
Diana V. Rodriguez-Moreno ◽  
Yael M. Cycowicz ◽  
Keely Cheslack-Postava ◽  
Huilan Tang ◽  
...  
Keyword(s):  
Substance Use ◽  
White Matter ◽  
Functional Connectivity ◽  
Substance Use Disorder ◽  
White Matter Integrity ◽  
Parental History ◽  
History Of

scholarly journals Pain sensitivity is inversely related to regional grey matter density in the brain

Pain ◽  
2014 ◽  
Vol 155 (3) ◽  
pp. 566-573 ◽  
Author(s):  
Nichole M. Emerson ◽  
Fadel Zeidan ◽  
Oleg V. Lobanov ◽  
Morten S. Hadsel ◽  
Katherine T. Martucci ◽  
...  
Keyword(s):  
Pain Sensitivity ◽  
Grey Matter ◽  
Matter Density ◽  
Grey Matter Density ◽  
The Brain

ELEVATED PLASMA NEUROFILAMENT LIGHT CHAIN IS ASSOCIATED WITH REDUCED GREY MATTER DENSITY IN AD AND MCI

2017 ◽  
Vol 13 (7) ◽  
pp. P1493
Author(s):  
Kacie Deters ◽  
Shannon L. Risacher ◽  
Kaj Blennow ◽  
Henrik Zetterberg ◽  
Michael Weiner ◽  
...  
Keyword(s):  
Light Chain ◽  
Grey Matter ◽  
Matter Density ◽  
Elevated Plasma ◽  
Neurofilament Light Chain ◽  
Neurofilament Light ◽  
Grey Matter Density

Voxel-based morphometry reveals an association between aerobic capacity and grey matter density in the right anterior insula

Neuroscience ◽  
2009 ◽  
Vol 163 (4) ◽  
pp. 1102-1108 ◽  
Author(s):  
J. Peters ◽  
M. Dauvermann ◽  
C. Mette ◽  
P. Platen ◽  
J. Franke ◽  
...  
Keyword(s):  
Aerobic Capacity ◽  
Grey Matter ◽  
Anterior Insula ◽  
Matter Density ◽  
Voxel Based Morphometry ◽  
Grey Matter Density ◽  
The Right

O3-03-06: Grey Matter Density in Relation to Cognitive Function

2016 ◽  
Vol 12 ◽  
pp. P288-P288
Author(s):  
Gennady V. Roshchupkin ◽  
Hazel I. Zonneveld ◽  
Hieab H.H. Adams ◽  
Meike W. Vernooij ◽  
Wiro J. Niessen ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Grey Matter ◽  
Matter Density ◽  
Grey Matter Density

Association of Age at Onset With Gray Matter Volume and White Matter Microstructural Abnormalities in People With Multiple Sclerosis

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000012869
Author(s):  
Raffaello Bonacchi ◽  
Alessandro Meani ◽  
Elisabetta Pagani ◽  
Olga Marchesi ◽  
Andrea Falini ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Gray Matter ◽  
Linear Models ◽  
Gray Matter Volume ◽  
Age At Onset ◽  
Healthy Controls ◽  
Compensatory Mechanisms ◽  
Cross Sectional ◽  
Matter Volume

Objective:To investigate whether age at onset influences brain gray matter volume (GMV) and white matter (WM) microstructural abnormalities in adult multiple sclerosis (MS) patients, given its influence on clinical phenotype and disease course.Method:In this hypothesis-driven cross-sectional study, we enrolled 67 pediatric-onset MS (POMS) patients and 143 sex- and disease duration (DD)-matched randomly-selected adult-onset MS (AOMS) patients, together with 208 healthy controls. All subjects underwent neurological evaluation and 3T MRI acquisition. MRI variables were standardized based on healthy controls, to remove effects of age and sex. Associations with DD in POMS and AOMS patients were studied with linear models. Time to reach clinical and MRI milestones was assessed with product-limit approach.Results:At DD=1 year, GMV and WM fractional anisotropy (FA) were abnormal in AOMS but not in POMS patients. Significant interaction of age at onset (POMS vs AOMS) into the association with DD was found for GMV and WM FA. The crossing point of regression lines in POMS and AOMS patients was at 20 years of DD for GMV and 14 for WM FA. For POMS and AOMS patients, median DD was 29 and 19 years to reach Expanded Disability Status Scale=3 (p<0.001), 31 and 26 years to reach abnormal Paced Auditory Serial Addition Task-3 (p=0.01), 24 and 18 years to reach abnormal GMV (p=0.04), and 19 and 17 years to reach abnormal WM FA (p=0.36).Conclusions:Younger patients are initially resilient to MS-related damage. Then, compensatory mechanisms start failing with loss of WM integrity, followed by GM atrophy and finally disability.

Sign in / Sign up

Export Citation Format

Share Document