Ataque de nervios has been studied for half a century, and is one of the best assessed cultural concepts of distress. Ataques were initially studied in Puerto Rican, Dominican, and Cuban samples by Latino researchers and anthropologists. Research indicates that ataques typically occur immediately after, or within a day of, a significant stressor. The characteristic symptoms of an ataque can be quite dramatic, and include emotional and physical symptoms along with displays of aggression and alterations in consciousness. In addition, 7%–14% of ataques result in suicide attempts. The chapter discusses this cultural concept of distress common among Latinos and shows how its relationship with psychopathology can vary depending upon the context, and can range from a normative response to stress to a marker of severe psychopathology.