Alzheimer’s Dementia From a Bilingual/Bicultural Perspective

2014 ◽  
Vol 36 (1) ◽  
pp. 55-64 ◽  
Author(s):  
Alejandro E. Brice ◽  
Sarah E. Wallace ◽  
Roanne G. Brice
Keyword(s):  
Medial Temporal Lobe ◽  
Alzheimer’S Dementia ◽  
Alzheimer's Dementia ◽  
Behavioral Indicators ◽  
Linguistic Differences ◽  
Early Evaluation ◽  
Beta Proteins ◽  
Magnetic Resonance Imaging Mri ◽  
Amyloid Beta Proteins

Alzheimer’s dementia (AD) is a progressive, degenerative disease that occurs in the cerebral cortex due to increased levels of glutamate, the proliferation of plaque-forming amyloid beta proteins, and reactive gliosis. Establishing behavioral indicators of the disease (e.g., impairments of episodic memory) and use of neuroimaging technology that can substantiate medial temporal lobe brain structure deficiencies demonstrates an important clinical neuroanatomic relationship needed for early evaluation of possible AD diagnosis. This bilingual/bicultural case study details the cognitive and language impairments associated with AD over the course of 1 year. Utilization of a bilingual/bicultural case study may elucidate the pattern of language and cognitive decline in this understudied population. Formal and informal measures, observations, and magnetic resonance imaging (MRI) results are provided. Insights into cultural and linguistic differences are presented.

scholarly journals P4-331: MEDIAL TEMPORAL LOBE STRUCTURAL DEFICITS ASSOCIATED WITH ALZHEIMER'S DEMENTIA IN INDIVIDUALS WITH DOWN SYNDROME

2019 ◽  
Vol 15 ◽  
pp. P1423-P1423
Author(s):  
Mithra Sathishkumar ◽  
John Janecek ◽  
Michael Phelan ◽  
David Keator ◽  
Eric Doran ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Alzheimer’S Dementia ◽  
Alzheimer's Dementia

scholarly journals A Comparative Analysis of Structural Brain MRI in the Diagnosis of Alzheimer’s Disease

2009 ◽  
Vol 21 (1-2) ◽  
pp. 13-19 ◽  
Author(s):  
Jason Appel ◽  
Elizabeth Potter ◽  
Qian Shen ◽  
Gustavo Pantol ◽  
Maria T. Greig ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Medial Temporal Lobe ◽  
Rating Scales ◽  
Brain Mri ◽  
Alzheimer’S Dementia ◽  
Alzheimer's Dementia ◽  
Increased Risk

Dementia is a debilitating and life-altering disease which leads to both memory impairment and decline of normal executive functioning. While causes of dementia are numerous and varied, the leading cause among patients 60 years and older is Alzheimer’s disease. The gold standard for Alzheimer’s diagnosis remains histological identification of amyloid plaques and neurofibrillary tangles within the medial temporal lobe, more specifically the entorhinal cortex and hippocampus. Although no definitive cure for Alzheimer's disease currently exists, there are treatments targeted at preserving cognition and memory while delaying continued loss of function. Alzheimer's disease exists along a spectrum of cognitive decline and is often preceded by Mild Cognitive Impairment (MCI). Patients with MCI demonstrate memory loss and cognitive impairment while still continuing normal activities of daily living, and are considered to be at increased risk for developing Alzheimer's Dementia. Identifying patients with prodromal states of Alzheimer's dementia such as MCI may allow initiation of appropriate treatment planning and delay of cognitive decline. Therefore, the need for a non-invasive early biomarker for the detection of Alzheimer's disease has never been greater. Multiple neuroimaging methods utilizing visual rating scales, volumetric measurements, and automated methods have been developed to identify, quantify, and track anatomic sequelae of Alzheimer’s Disease.

Serum and cerebrospinal fluid cystatin C levels in vascular and Alzheimer's dementia

2000 ◽  
Vol 101 (4) ◽  
pp. 279-282 ◽  
Author(s):  
J. Kalman ◽  
J. Marki-Zay ◽  
A. Juhasz ◽  
A. Santha ◽  
L. Dux ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Cystatin C ◽  
Alzheimer’S Dementia ◽  
Alzheimer's Dementia
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