Multi-wavelength Time Domain Optical Mammography

A time-resolved optical mammograph operating at 7 wavelengths (637, 683, 785, 832, 905, 916, and 975 nm) in compressed breast geometry was developed. Its clinical application was started on patients bearing malignant and benign lesions. Late gated intensity images are used to obtain information on the spatial distribution of the absorption properties of breast. Scattering images derived from the diffusion theory are also applied for lesion detection and characterization. Cancers are identified in intensity images at short wavelengths, due to the high blood content, while cysts are typically characterized by low scattering at all wavelengths. The increase (from 4 to 7) in the number of wavelengths as compared to the previous versions of the instrument aims at improving the robustness of the fitting procedures for a better estimate of tissue composition and structure and of physiological parameters. Moreover, the new wavelengths contribute to the qualitatively identify tissue composition from intensity images, and could assist lesion detection.

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Multi-wavelength time-resolved optical mammography

Biomedical Topical Meeting ◽

10.1364/bio.2004.thb3 ◽

2004 ◽

Cited By ~ 1

Author(s):

P. Taroni ◽

L. Pallaro ◽

A. Pifferi ◽

L. Spinelli ◽

A. Torricelli ◽

...

Keyword(s):

Time Resolved ◽

Optical Mammography ◽

Multi Wavelength

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Bulk hemoglobin, lipid and water content in the female breast from multi-wavelength time-resolved optical mammography

Biomedical Topical Meeting ◽

10.1364/bio.2004.thb5 ◽

2004 ◽

Author(s):

Lorenzo Spinelli ◽

Alessandro Torricelli ◽

Antonio Pifferi ◽

Paola Taroni ◽

Rinaldo Cubeddu ◽

...

Keyword(s):

Water Content ◽

Time Resolved ◽

Optical Mammography ◽

Female Breast ◽

Multi Wavelength

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Characterization of female breast lesions from multi-wavelength time-resolved optical mammography

Physics in Medicine and Biology ◽

10.1088/0031-9155/50/11/004 ◽

2005 ◽

Vol 50 (11) ◽

pp. 2489-2502 ◽

Cited By ~ 68

Author(s):

Lorenzo Spinelli ◽

Alessandro Torricelli ◽

Antonio Pifferi ◽

Paola Taroni ◽

Gianmaria Danesini ◽

...

Keyword(s):

Breast Lesions ◽

Time Resolved ◽

Optical Mammography ◽

Female Breast ◽

Multi Wavelength

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Six-year source apportionment of submicron organic aerosols from near-continuous measurements at SIRTA (Paris area, France)

10.5194/acp-2019-515 ◽

2019 ◽

Author(s):

Yunjiang Zhang ◽

Olivier Favez ◽

Jean-Eudes Petit ◽

Francesco Canonaco ◽

Francois Truong ◽

...

Keyword(s):

Source Apportionment ◽

Biomass Burning ◽

Ambient Air ◽

Carbonaceous Aerosols ◽

Time Resolved ◽

Pronounced Increase ◽

Paris Area ◽

Multi Wavelength ◽

High Concentrations

Abstract. Organic aerosol (OA) particles are recognized as key factors influencing air quality and climate change. However, highly-time resolved year-round characterizations of their composition and sources in ambient air are still very limited due to challenging continuous observations. Here, we present an analysis of long-term variability of submicron OA using the combination of Aerosol Chemical Speciation Monitor (ACSM) and multi-wavelength aethalometer from November 2011 to March 2018 at a background site of the Paris region (France). Source apportionment of OA was achieved via partially constrained positive matrix factorization (PMF) using the multilinear engine (ME-2). Two primary OA (POA) and two oxygenated OA (OOA) factors were identified and quantified over the entire studied period. POA factors were designated as hydrocarbon-like OA (HOA) and biomass burning OA (BBOA). The latter factor presented a significant seasonality with higher concentrations in winter with significant monthly contributions to OA (18–33 %) due to enhanced residential wood burning emissions. HOA mainly originated from traffic emissions but was also influenced by biomass burning in cold periods. OOA factors were distinguished between their less- and more-oxidized fractions (LO-OOA and MO-OOA, respectively). These factors presented distinct seasonal patterns, associated with different atmospheric formation pathways. A pronounced increase of LO-OOA concentrations and contributions (50–66 %) was observed in summer, which may be mainly explained by secondary OA (SOA) formation processes involving biogenic gaseous precursors. Conversely high concentrations and OA contributions (32–62 %) of MO-OOA during winter and spring seasons were partly associated with anthropogenic emissions and/or long-range transport from northeastern Europe. The contribution of the different OA factors as a function of OA mass loading highlighted the dominant roles of POA during pollution episodes in fall and winter, and of SOA for highest springtime and summertime OA concentrations. Finally, long-term trend analyses indicated a decreasing feature (of about 200 ng m−3 yr−1) for MO-OOA, very limited or insignificant decreasing trends for primary anthropogenic carbonaceous aerosols (BBOA and HOA, along with the fossil fuel and biomass burning black carbon components), and no trend for LO-OOA over the 6+-year investigated period.

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Development and evaluation of a multi-wavelength multi-channel time resolved optical instrument for NIR/MRI mammography co-registration

Proceedings of the IEEE 28th Annual Northeast Bioengineering Conference (IEEE Cat. No.02CH37342) ◽

10.1109/nebc.2002.999480 ◽

2003 ◽

Cited By ~ 3

Author(s):

X. Intes ◽

Jiangsheng Yu ◽

A.G. Yodh ◽

B. Chance

Keyword(s):

Optical Instrument ◽

Time Resolved ◽

Multi Wavelength

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Development of optical mammography based on analysis of time-resolved photon path distribution

10.1117/12.843027 ◽

2010 ◽

Author(s):

Y. Ueda ◽

D. Yamashita ◽

K. Yoshimoto ◽

E. Ohmae ◽

T. Suzuki ◽

...

Keyword(s):

Time Resolved ◽

Optical Mammography ◽

Photon Path

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Histologic Study of Intravelar Structures in Normal Human Adult Specimens

The Cleft Palate-Craniofacial Journal ◽

10.1597/04-125r.1 ◽

2005 ◽

Vol 42 (5) ◽

pp. 481-489 ◽

Cited By ~ 30

Author(s):

David P. Kuehn ◽

Jerald B. Moon

Keyword(s):

Soft Palate ◽

Hard Palate ◽

Tissue Composition ◽

Posterior Border ◽

Histologic Study ◽

Levator Veli Palatini ◽

Composition And Structure ◽

Uniform Function ◽

Substantial Investment ◽

Normal Human

Objective To describe more clearly the tissue composition and structure of the human soft palate with particular emphasis on the central portion between the faucial pillars. Specimens Nine female and three male normal adult human soft palate cadaver specimens. Results The anterior soft palate consists of fairly uniform layers. The anterior one fourth contains a substantial investment of mucous-secreting glandular tissue, as well as an abundance of adipose tissue. The tensor veli palatini tendon is prominent in the most anterior region just posterior to the hard palate and close to the nasal surface. The middle one third of the soft palate is largely invested with muscle tissue consisting of (1) levator veli palatini fibers coursing transversely across the midline without a septal interruption, (2) musculus uvulae fibers encapsulated in a sheath and coursing longitudinally, perpendicular to and cradled by the levator sling, and (3) palatopharyngeus fibers located laterally and not approaching the midline. Musculus uvulae is variable across and within specimens in terms of its paired versus unpaired nature. Conclusions The anatomy of the soft palate from the posterior border of the hard palate to the levator veli palatini sling is consistent among specimens, suggesting that structures in this region have a uniform function across subjects. The paired versus unpaired nature of musculus uvulae is variable both within and between specimens. The posterior one third of the soft palate is variable across specimens with regard to the relative amount and distribution of different tissue types.

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