Assessment of Drivers and Deterrents of Development of High-Speed Passenger Railway Transportation

Reduction in travel time is one of the eloquent trends in transport developments. It is consistent with the desire of leading transport companies to create conditions to increase traffic speeds.The objective of the article is to analyse prospects and drivers for development of high-speed rail transportation as of a priority transport segment characterised by best safety rates and environmental friendliness as compared to other types of transportation.The review of core parameters of HSR is suggested to show features of its global development.Ecological friendliness, encouragement of labour and other mobility of people, of innovative technology development of railways and interconnected industries are most relevant as universal drivers of HSR development.Constraints due to substantial investment needs, long payback period, necessity to implement additional side projects to develop interrelated transport infrastructure to obtain more tangible economic and social effects, to provide for sufficient passenger flow at the initial or further stages of HSR operation were considered as main deterrents.The factors, their parameters, assessment of their priority ranking when making decisions on construction or development of HSR are determined in each country by transport development strategies, current economic conditions, and a set of other factors.

Environmental Factors as Diabetic Mediators–A Mechanistic Approach

Despite substantial investment in research and treatment options, diabetes mellitus remains a pressing public health concern with potential epidemic proportions globally. There are reports that by the end of 2040, 642 million people will be suffering from diabetes. Also, according to an estimation, 1.6 million deaths were caused directly by diabetes in 2016. Diabetes is a metabolic disorder characterized by impaired glucose regulation in the body due to the destruction of pancreatic β-cells or insulin resistance. Genetic propensity, unhealthy and imbalanced diet, obesity and increasing urbanization are the common risk factors for diabetes. Besides this, it has been reported that environmental pollutants like organic pesticides, heavy metals, and air pollutants act as strong predisposing factors for diabetes owing to their highly bio-accumulative nature. These pollutants disturb glucose homeostasis either by up-regulating or down-regulating the expression of diabetic marker genes like insulin (INS), glucokinase (GCK). Unfortunately, the molecular mechanism about the role of pollutants in causing diabetes is not very clear. This mechanistic review provides evidence of different environmental determinants including persistent organic pollutants (POPs), air pollutants, toxic metals, etc. in inducing diabetes and proposes a framework for the possible mechanisms involved. It also illuminates the current status and future challenges which will not only broaden our understanding but can also be a reasonable platform for further investigation.

Clinical and Economic Burden of Bacteraemia Due To Multi-Drug-Resistant Organisms in Korea: A Prospectively Selected Case Control Study

BackgroundMultidrug-resistant organisms (MDROs), including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), multidrug resistant Acinetobacter baumannii (MRAB), multidrug resistant Pseudomonas aeruginosa (MRPA), and carbapenem-resistant Enterobacteriaceae (CRE) are particularly important public health threats, but their detailed clinical outcomes and socioeconomic burden are adequately addressed.MethodsWe prospectively searched for these MDROs bacteraemia cases with matched controls from 10 hospitals across Korea, in a 6-month period, in 2017. Patients were classified into the MDRO, susceptible organism, and no-infection groups. The corresponding susceptible or no-infection controls had similar principal diagnosis at admission time, major surgery or intervention during hospitalization, age (± 10 years), sex, and within ± 60 days of admission date. We collected detailed clinical information and estimated the total additional direct medical cost of each MDRO bacteraemia case using the multistate model. ResultsOf 486 MDRO bacteraemia cases identified for MRSA, MRAB, MRPA, CRE, and VRE, at 260, 87, 18, 20, and 101, respectively, their 90-day mortality rates (overall, 40.3%) were 30.4%, 63.2%, 16.7%, 55.0%, and 47.5%, respectively. Their additional medical costs (overall, $27,700) were $15,768, $35,682, $39,908, $72,051, and $33,662 (compared to the no-infection group), respectively. Overall, these five MDRO bacteraemia cases occurred in 7,979 patients, caused 3,280 deaths, and cost $294,505,002 (range, $170,627,020 to $416,094,679) socioeconomic loss. ConclusionsTremendous clinical and economic burden occurred with MDRO bacteraemia compared with those of antibiotic-susceptible and no-infection groups. Substantial investment and efforts by related government agencies and medical staffs are needed to urgently prevent the increase, spread and expansion of antibiotic-resistant bacteria.

What's Stopping Knowledge Synthesis? A Systematic Review of Recent Practices in Research on Smallholder Diversity

A systematic review of recent publications was conducted to assess the extent to which contemporary micro-level research on smallholders facilitates data re-use and knowledge synthesis. Following PRISMA standards for systematic review, 1,182 articles were identified (published between 2018 and 2020), and 261 articles were selected for review in full. The themes investigated were: (i) data management, including data source, variables collected, granularity, and availability of the data; (ii) the statistical methods used, including analytical approach and reproducibility; and (iii) the interpretation of results, including the scope and objectives of the study, development issues addressed, scale of recommendations made relative to the scale of the sample, and the audience for recommendations. It was observed that household surveys were the most common data source and tended to be representative at the local (community) level. There was little harmonization of the variables collected between studies. Over three quarters of the studies (77%) drew on data which was not in the public domain, 14% published newly open data, and 9% drew on datasets which were already open. Other than descriptive statistics, linear and logistic regression methods were the most common analytical method used (64% of articles). In the vast majority of those articles, regression was used as an explanatory tool, as opposed to a predictive tool. More than half of the articles (59%) made claims or recommendations which extended beyond the coverage of their datasets. In combination these two common practices may lead to erroneous understanding: the tendency to rely upon simple regressions to explain context-specific and complex associations; and the tendency to generalize beyond the remit of the data collected. We make four key recommendations: (1) increased data sharing and variable harmonization would enable data to be re-used between studies; (2) providing detailed meta-data on sampling frames and study-context would enable more powerful meta-analyses; (3) methodological openness and predictive modeling could help test the transferability of approaches; (4) more precise language in study conclusions could help decision makers understand the relevance of findings for policy planning. Following these practices could leverage greater benefits from the substantial investment already made in data collection on smallholder farms.

Baladna Goes Global

Baladna is a dairy company in Qatar. It has thrived despite an ongoing political and economic blockade, helping the country to become self-sufficient in terms of its dairy needs. In a short time and with substantial investment, the brand became a market leader. Baladna’s growth plan banks on globalization, but the marketing director and the VP of marketing disagree on the strategy: one argues for standardization and the other for adaptation. The case study discusses brand name issues as well as brand identity approaches in the context of a multicultural environment.

Stuart Cunningham: From creative industries to creative economies, and beyond

This paper explores Stuart Cunningham’s thought leadership in ‘creative’ spaces since the turn of the millennium. It presents the author's personal glimpses of Cunningham's contributions to scholarship and advocacy, ranging from Cunningham and Hartley's exposé on the recently-titled creative industries at the National Humanities and Social Sciences Summit (Canberra, 2001), through the establishment of QUT's Centre of Excellence (Brisbane, 2005) and its European node (London, 2008), to Cunningham's more recent work with creative economies and their opportunities, including his influence upon Australia's Cultural and Creative Economy: A 21st-Century Guide (Canberra, 2020). The paper concludes with some comments about continuing resistance to substantial investment in Australia's creative industries, and Cunningham's call for a more united voice in their advocacy.

Public-Private Partnerships and the Healthcare Sector Performance in Kenya

Healthcare is one of the fundamental development agenda to any nation and its adequate provision in an accessible, quality and sustainable manner is the supreme responsibility of the state. However, the burden of healthcare cannot be met by the government alone, but requires substantial investment from the private sector as well. This article reviews the existing empirical literature to examine the contribution of private investment on the healthcare sector performance in Kenya. Existing evidence shows that there is minimal private-public partnership in the health sector in Kenya. The main factors inhibiting private-public partnership investment in the sector were attributed to the uncertainty associated with universal healthcare. Further, the scheme is characterised by an overall lack of transparency and accountability surrounding contracts, costing and allocations with many of the safeguards against these kinds of challenges blatantly ignored by several actors and in turn raising issues of accessibility for citizens. Also, private sector credit and political regimes have a negative but significant influence on private investments generally.

Basic Research Funding Solutions at Regional Level: Krasnoyarsk Territory Case

Introduction. The country's research and innovation domain and its research potential constitute a definitive formative factor of the knowledge-based economy and are a strategic priority when it comes to the state's economic security and better quality of life for the population. However, despite the Russian government's substantial investment in research and innovation, the field remains underproductive. Methods. The article analyses the approaches and sources of funding for fundamental and exploratory research in the regions, and identifies the existing funding models for fundamental research. To this end, the general research methods were employed, such as scientific observation, scientific description of the subjects and objects of research, and scientific analysis. Results and Discussion. It has been determined that, under the current legislation, there are no opportunities for the regions of the Russian Federation to finance fundamental or exploratory research directly. The writer analyses the case of the Russian Foundation for Basic Research (RFBR), which holds regional competitions in basic research, and uses a model whereby the winning projects receive funding. The model involving a regional research foundation is recognised as the more successful option for the advancement of fundamental and exploratory research in the region. A comparative analysis of the regional RFBR and RSF competitions has revealed the following differences: in the RSF competitions, the regional side is almost entirely excluded from the decision-making process; there are high entry and project performance requirements, so the less advanced regions are forced to compete with the more scientifically advanced contenders. Conclusion. The positive side of the ongoing changes is that the level of research is rising, but at the same time the regions lose a certain important aspect of the fostering of regional researchers: the regional RFBR competitions were a pilot stage launched in order to understand and try out the grant funding system and requirements. And this is why the relevance of the regional research foundations is so high: they help to make up for these setbacks.

School Failure in the Region of Madrid (Spain): An Approximation through Diagnostic Assessment in 2019

Education is considered to be one of the main factors of development, economic growth and social progress. No country can achieve sustainable economic development without substantial investment in human capital. In Spain, school failure represents one of the main problems in the educational system, with potentially dramatic consequences for the basic competences required in the labour market and job instability, with the risk of economic and social exclusion. In this paper, we aim to identify the factors that define the risk of school failure in Madrid (Spain) by applying logit models. In this process we use a definition of school failure risk which relates to the probability of scoring below level 2 in the evaluation of competences (diagnostic assessment), and we use grade retention as a proxy of school failure. The variables included in the model cover several areas, such as personal, family and school characteristics. The results show that it is important that the policies to strengthen the educational system begin with early childhood education, as educational delay symptoms are detected, and it is necessary to intensify efforts towards personalized assistance to help identify potential learning problems, especially in those groups in the worst socioeconomic situations, which are most at risk of school failure.

A Holistic Approach for Optimal Pre-Planning of Multi-Path Standardized Taxiing Routes

Standardized Taxiing Routes (STRs) are defined as published taxiing-in and taxiing-out routes for aircraft between gates and runways, aiming at improving ground movement safety at busy or complex airports. Most of the STRs specify only one path between each O–D (Origin–Destination) pair, which compromises the flexibility of route choice in time-varying traffic scenarios. In this paper, we present a holistic approach of planning and validating Multi-Path Standardized Taxiing Routes (MPSTRs) based on System-Optimal Traffic Assignment (SOTA), by firstly defining the flow-based congestion cost of runway, taxiway, and sectorized apron operation at a macroscopic level. A human-in-the-loop experiment comprised of six operation scenarios follows to investigate the impact of the pre-planned MPSTRs on human controllers’ performance. Results confirm the positive effect of the MPSTRs on taxiing performance without increasing the controllers’ workload, which also implies that the MPSTRs would be a promising approach for balancing safety and efficiency for the STRs-based taxiing operation and dynamic routing optimization without substantial investment.