Review: Optical Micrometer Resolution Scanning for Non-invasive Grading of Precancer in the Human Uterine Cervix

2008 ◽  
Vol 7 (6) ◽  
pp. 483-496 ◽  
Author(s):  
Florian Bazant-Hegemark ◽  
Katharine Edey ◽  
Gordon R. Swingler ◽  
Mike D. Read ◽  
Nicholas Stone

Management of cervical precancer is archetypal for other cancer prevention programmes but has to consider diagnostic and logistic challenges. Numerous optical tools are emerging for non-destructive near real-time early diagnosis of precancerous lesions of the cervix. Non-destructive, real-time imaging modalities have reached pre-commercial status, but high resolution mapping tools are not yet introduced in clinical settings. The NCBI PubMed web page was searched using the keywords ‘CIN diagnosis’ and the combinations of ‘cervix {confocal, optical coherence tomography, ftir, infrared, Raman, vibrational, spectroscopy}’. Suitable titles were identified and their relevant references followed. Challenges in precancer management are discussed. The following tools capable of non-destructive high resolution mapping in a clinical environment were selected: confocal microscopy, optical coherence tomography, IR spectroscopy, and Raman spectroscopy. Findings on the clinical performance of these techniques are put into context in order to assist the reader in judging the likely performance of these methods as diagnostic tools. Rationale for carrying out research under the prospect of the HPV vaccine is given.

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chenchen Ren ◽  
Xianxu Zeng ◽  
Zhongna Shi ◽  
Chunyan Wang ◽  
Huifen Wang ◽  
...  

AbstractIn this prospective study of an in-vivo cervical examination using optical coherence tomography (OCT), we evaluated the diagnostic value of non-invasive and real-time OCT in cervical precancerous lesions and cancer diagnosis, and determined the characteristics of OCT images. 733 patients from 5 Chinese hospitals were inspected with OCT and colposcopy-directed biopsy. The OCT images were compared with the histological sections to find out the characteristics of various categories of lesions. The OCT images were also interpreted by 3 investigators to make a 2-class classification, and the results were compared against the pathological results. Various structures of the cervical tissue were clearly observed in OCT images, which matched well with the corresponding histological sections. The OCT diagnosis results delivered a sensitivity of 87.0% (95% confidence interval, CI 82.2–90.7%), a specificity of 84.1% (95% CI 80.3–87.2%), and an overall accuracy of 85.1%. Both good consistency of OCT images and histological images and satisfactory diagnosis results were provided by OCT. Due to its features of non-invasion, real-time, and accuracy, OCT is valuable for the in-vivo evaluation of cervical lesions and has the potential to be one of the routine cervical diagnosis methods.


2020 ◽  
Vol 87 (6) ◽  
pp. 404-413
Author(s):  
Fabian Zechel ◽  
Rouwen Kunze ◽  
Niels König ◽  
Robert Heinrich Schmitt

AbstractIn this review paper, conventional non-destructive testing (NDT) methods are briefly introduced and compared with selected examples for applications of optical coherence tomography (OCT) for NDT. The contactless, non-destructive and purely optical method enables multi-dimensional imaging for tomographic real-time evaluation in various fields of application. Depending on the material, penetration depths of several millimeters can be achieved, thus providing an attractive solution that can be used both as a stand-alone and as a process-integrated solution.


2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Verônica Castro Lima ◽  
Eduardo B. Rodrigues ◽  
Renata P. Nunes ◽  
Juliana F. Sallum ◽  
Michel E. Farah ◽  
...  

We aimed to evaluate technical aspects and the clinical relevance of a simultaneous confocal scanning laser ophthalmoscope and a high-speed, high-resolution, spectral-domain optical coherence tomography (SDOCT) device for retinal imaging. The principle of confocal scanning laser imaging provides a high resolution of retinal and choroidal vasculature with low light exposure. Enhanced contrast, details, and image sharpness are generated using confocality. The real-time SDOCT provides a new level of accuracy for assessment of the angiographic and morphological correlation. The combined system allows for simultaneous recordings of topographic and tomographic images with accurate correlation between them. Also it can provide simultaneous multimodal imaging of retinal pathologies, such as fluorescein and indocyanine green angiographies, infrared and blue reflectance (red-free) images, fundus autofluorescence images, and OCT scans (Spectralis HRA + OCT; Heidelberg Engineering, Heidelberg, Germany). The combination of various macular diagnostic tools can lead to a better understanding and improved knowledge of macular diseases.


2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Niels M. Israelsen ◽  
Christian R. Petersen ◽  
Ajanta Barh ◽  
Deepak Jain ◽  
Mikkel Jensen ◽  
...  

2015 ◽  
Vol 56 (11) ◽  
pp. 6654 ◽  
Author(s):  
Patrick Steiner ◽  
Andreas Ebneter ◽  
Lieselotte Erika Berger ◽  
Martin Zinkernagel ◽  
Boris Považay ◽  
...  

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