Sonogashira coupling reactions: Synthesis of 4-substituted-6-methyl-2-(methylthio)pyrimidines catalyzed by Pd–Cu

2019 ◽  
Vol 43 (9-10) ◽  
pp. 431-436
Author(s):  
Fatemeh Rezaeimanesh ◽  
Mohammad Bakherad ◽  
Hossein Nasr-Isfahani
Keyword(s):  
Efficient Method ◽  
Room Temperature ◽  
Reaction Times ◽  
Coupling Reactions ◽  
Sonogashira Coupling ◽  
Aryl Iodides ◽  
Palladium Catalyzed ◽  
Sonogashira Reactions

An efficient method is developed for the synthesis of 4-(3-arylprop-2-ynyloxy)-6-methyl-2-(methylthio)pyrimidines via palladium-catalyzed Sonogashira reactions of 4-methyl-2-(methylthio)-6-(prop-2-yn-1-yloxy)pyrimidine with electron-poor aryl iodides in acetonitrile at room temperature. Excellent yields of the products were obtained in reaction times of 9–11 h.

A Convenient Procedure for Sonogashira Reactions Using Propyne

Synthesis ◽  
2021 ◽  
Author(s):  
George A. Kraus ◽  
Joshua L Alterman
Keyword(s):  
Room Temperature ◽  
Sonogashira Coupling ◽  
Convenient Procedure ◽  
Aryl Iodides ◽  
Sonogashira Reactions

A modified Sonogashira coupling of aryl iodides and propyne was achieved using only two equivalents of propyne in THF from -78°C to room temperature.

Diiiodine/Potassium Persulfate Mediated Synthesis of 1,2,3-Thiadiazoles from N-Tosylhydrazones and a Thiocyanate Salt as a Sulfur Source under Transition-Metal-Free Conditions

Synlett ◽  
2021 ◽  
Author(s):  
Yadong Sun ◽  
Ablimit Abdukader ◽  
Yuhan Lu ◽  
Chenjiang Liu
Keyword(s):  
Transition Metal ◽  
Efficient Method ◽  
Room Temperature ◽  
Functional Group ◽  
Ammonium Thiocyanate ◽  
Potassium Persulfate ◽  
Sulfur Source ◽  
Coupling Reactions ◽  
Wide Scope ◽  
Metal Free

AbstractA highly efficient method for the synthesis of 1,2,3-thiadiazoles has been developed by utilizing readily available tosylhydrazones and ammonium thiocyanate with ecofriendly EtOH as the solvent at room temperature. The reaction shows a wide scope of substrates and good functional-group tolerance. This protocol can be scaled up to a gram level and can be applied to coupling reactions with 4-(4-bromophenyl)-1,2,3-thiadiazole as the substrate.

scholarly journals Oxidation of Some Organic Diols with Trialkylammonium Fluorochromates(VI), R3NH[CrO3F], (R= CH3, C2H5, C3H7 and C4H9) at Room Temperature and Under Microwave Condition

2019 ◽  
Vol 53 (2) ◽  
Author(s):  
Shahriar Ghammamy ◽  
Samira Khorsandtabar ◽  
Ali Moghimi ◽  
Hajar Sahebalzamani
Keyword(s):  
Microwave Radiation ◽  
Efficient Method ◽  
Room Temperature ◽  
Reaction Times ◽  
Work Up

A mild and efficient method for the mono-oxidation of diols to the corresponding hydroxyaldehydes with trialkylammonium fluorochromates(VI), R3NH[CrO3F] (R= CH3, C2H5, C3H7 and C4H9), in solution at room temperature, and in solution under microwave radiation, is reported. The easy procedure, simple work-up, short reaction times, and excellent yields are advantages of these reagents.

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