Highly chemoselective palladium-catalyzed Sonogashira coupling of 5-iodouridine-5′-triphosphates with propargylamine: a new efficient method for the synthesis of 5-aminopropargyl-uridine-5′-triphosphates

2012 ◽  
Vol 53 (24) ◽  
pp. 3070-3072 ◽  
Author(s):  
Anilkumar R. Kore ◽  
Annamalai Senthilvelan ◽  
Muthian Shanmugasundaram
Keyword(s):  
Efficient Method ◽  
Sonogashira Coupling ◽  
Palladium Catalyzed

Sonogashira coupling reactions: Synthesis of 4-substituted-6-methyl-2-(methylthio)pyrimidines catalyzed by Pd–Cu

2019 ◽  
Vol 43 (9-10) ◽  
pp. 431-436
Author(s):  
Fatemeh Rezaeimanesh ◽  
Mohammad Bakherad ◽  
Hossein Nasr-Isfahani
Keyword(s):  
Efficient Method ◽  
Room Temperature ◽  
Reaction Times ◽  
Coupling Reactions ◽  
Sonogashira Coupling ◽  
Aryl Iodides ◽  
Palladium Catalyzed ◽  
Sonogashira Reactions

An efficient method is developed for the synthesis of 4-(3-arylprop-2-ynyloxy)-6-methyl-2-(methylthio)pyrimidines via palladium-catalyzed Sonogashira reactions of 4-methyl-2-(methylthio)-6-(prop-2-yn-1-yloxy)pyrimidine with electron-poor aryl iodides in acetonitrile at room temperature. Excellent yields of the products were obtained in reaction times of 9–11 h.

ChemInform Abstract: An Efficient Method for the Preparation of Tertiary Esters by Palladium-Catalyzed Alkoxycarbonylation of Aryl Bromides.

ChemInform ◽  
2012 ◽  
Vol 43 (19) ◽  
pp. no-no
Author(s):  
Zhuo Xin ◽  
Thomas M. Goegsig ◽  
Anders T. Lindhardt ◽  
Troels Skrydstrup
Keyword(s):  
Efficient Method ◽  
Aryl Bromides ◽  
Palladium Catalyzed

A General Palladium-Catalyzed Carbonylative Sonogashira Coupling of Aryl Triflates

2010 ◽  
Vol 17 (1) ◽  
pp. 106-110 ◽  
Author(s):  
Xiao-Feng Wu ◽  
Basker Sundararaju ◽  
Helfried Neumann ◽  
Pierre H. Dixneuf ◽  
Matthias Beller
Keyword(s):  
Sonogashira Coupling ◽  
Palladium Catalyzed

scholarly journals Combined directed ortho-zincation and palladium-catalyzed strategies: Synthesis of 4,n-dimethoxy-substituted benzo[b]furans

2011 ◽  
Vol 7 ◽  
pp. 1255-1260 ◽  
Author(s):  
Verónica Guilarte ◽  
M Pilar Castroviejo ◽  
Estela Álvarez ◽  
Roberto Sanz
Keyword(s):  
Methoxy Group ◽  
Sonogashira Coupling ◽  
Furan Derivatives ◽  
Iodination Reaction ◽  
Palladium Catalyzed

A new route to regioselectively dialkoxy-functionalized benzo[b]furan derivatives has been developed from 3-halo-2-iodoanisoles bearing an additional methoxy group, which have been accessed through an ortho-zincation/iodination reaction. Two palladium-catalyzed processes, namely a Sonogashira coupling followed by a tandem hydroxylation/cyclization sequence, give rise to new and interesting dimethoxy-substituted benzo[b]furans.

Diversity-Oriented Synthesis of Substituted Furo[2,3-b]pyrazines

2009 ◽  
Vol 62 (1) ◽  
pp. 27 ◽  
Author(s):  
Vaibhav P. Mehta ◽  
Sachin G. Modha ◽  
Denis Ermolat'ev ◽  
Kristof Van Hecke ◽  
Luc Van Meervelt ◽  
...  
Keyword(s):  
Efficient Method ◽  
Electrophilic Cyclization ◽  
Diversity Oriented Synthesis ◽  
Highly Efficient ◽  
Palladium Catalyzed ◽  
Catalyzed Reactions

A highly efficient method for the synthesis of diversely substituted furo[2,3-b]pyrazines has been elaborated. The Ag+- or iodine-mediated electrophilic cyclization of readily generated 5-chloro-3-substituted ethynyl-1-(4-methoxybenzyl)-pyrazin-2(1H)-ones affords substituted furo[2,3-b]pyrazines, which undergo various palladium catalyzed reactions to generate a library of difficult to attain diversely substituted furo[2,3-b]pyrazines.

Palladium-catalyzed Sonogashira coupling of amides: access to ynones via C–N bond cleavage

2016 ◽  
Vol 52 (81) ◽  
pp. 12076-12079 ◽  
Author(s):  
Ming Cui ◽  
Hongxiang Wu ◽  
Junsheng Jian ◽  
Hui Wang ◽  
Chao Liu ◽  
...  
Keyword(s):  
Functional Group ◽  
Bond Cleavage ◽  
Catalyst Loading ◽  
Sonogashira Coupling ◽  
Broad Array ◽  
Palladium Catalyzed ◽  
Low Catalyst Loading

The first palladium-catalyzed Sonogashira coupling of amides has been developed, which proceeds via a selective cleavage of the N-acylsaccharin C–N bond. The protocol is mild, highly functional group tolerant and can be efficiently employed in the synthesis of a broad array of ynones in 48–98% yields under low catalyst loading and Cu-free conditions.

Microwave-assisted palladium mediated efficient synthesis of pyrazolo[3,4-b]pyridines, pyrazolo[3,4-b]quinolines, pyrazolo[1,5-a]pyrimidines and pyrazolo[1,5-a]quinazolines

RSC Advances ◽  
2014 ◽  
Vol 4 (46) ◽  
pp. 24001-24006 ◽  
Author(s):  
Kommuri Shekarrao ◽  
Partha Pratim Kaishap ◽  
Venkateshwarlu Saddanapu ◽  
Anthony Addlagatta ◽  
Sanjib Gogoi ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Efficient Method ◽  
Solvent Free ◽  
Efficient Synthesis ◽  
Aryl Aldehydes ◽  
Microwave Assisted ◽  
Fused Heterocycles ◽  
Palladium Catalyzed ◽  
Solvent Free Reaction

An efficient method was developed for the synthesis of pyrazole fused heterocycles via the palladium-catalyzed solvent free reaction of β-halovinyl/aryl aldehydes and 3-aminopyrazoles/5-aminopyrazoles under microwave irradiation in good yields.

Palladium-catalyzed reductive cross-coupling between α-bromo carboxamides and terminal alkynes

2020 ◽  
Vol 7 (21) ◽  
pp. 3505-3508
Author(s):  
Muinat A. Aliyu ◽  
Bowen Li ◽  
He Yang ◽  
Wenjun Tang
Keyword(s):  
Cross Coupling ◽  
Sonogashira Coupling ◽  
Terminal Alkynes ◽  
Palladium Catalyzed

A Pd-catalyzed reductive cross-coupling between α-bromo carboxamides and terminal alkynes was developed featuring a radical pathway and distinct from the Sonogashira coupling.

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