Giant cell tumour of hand bones: outcomes of treatment

2021 ◽  
pp. 175319342110078
Author(s):  
Ajay Puri ◽  
Rohit Rajalbandi ◽  
Ashish Gulia
Keyword(s):  
Giant Cell ◽  
Giant Cell Tumour ◽  
Treatment Options ◽  
Rare Condition ◽  
Asian Population ◽  
Cell Tumour ◽  
Level Of Evidence ◽  
Hand Bones ◽  
Giant Cell Tumours ◽  
Treatment Morbidity

The purpose of this study was to report the incidence of giant cell tumour of the hand bones in an Asian population, document treatment options and report outcomes of treatment. Of 698 giant cell tumours of bone that underwent surgery between January 2011 and December 2020 at our institute, only 22 (3%) were in the hand. Fourteen occurred in the metacarpals, eight in the phalanges. Fifteen were primary tumours and seven had recurrent disease. Twenty lesions had an associated soft tissue component. Two patients treated for primary disease and one who had been treated for recurrence had local recurrence. Recurrence occurred in two of nine patients treated with curettage, one of three with resection and none of five with ray or digit amputation. Both curettage and resection/amputation are acceptable treatment options for the rare condition of giant cell tumour of bone in the hand, with a need to individualize treatment decisions based on the site and extent of disease to minimize treatment morbidity while maximizing disease control. Level of evidence: IV

Radiological Assessment of Giant Cell Tumour of Bone in the Sacrum: From Diagnosis to Treatment Response Evaluation

2021 ◽  
Vol 17 ◽  
Author(s):  
Kirsten Van Langevelde ◽  
Niels Van Vucht ◽  
Shinji Tsukamoto ◽  
Andreas F. Mavrogenis ◽  
Costantino Errani
Keyword(s):  
Soft Tissue ◽  
Giant Cell ◽  
Giant Cell Tumour ◽  
Imaging Modality ◽  
Treatment Options ◽  
World Health Organisation ◽  
Axial Skeleton ◽  
Cell Tumour ◽  
World Health ◽  
Response Evaluation

: Giant cell tumour of bone (GCTB) typically occurs in young adults from 20-40 years old. Although the majority of lesions are located in the epi-metaphyses of the long bones, approximately one third of tumours is located in the axial skeleton, of which only 4% in the sacrum. Sacral tumours tend to be large at the time of presentation, and they present with aggressive features such as marked cortical destruction and an associated soft tissue component. The 2020 World Health Organisation classification of Soft Tissue and Bone Tumours describes GCTB as neoplasm which is locally aggressive and rarely metastasizing. The tumour contains three different cell types: neoplastic mononuclear stromal cells, macrophages and osteoclast-like giant cells. Two tumour subtypes were defined: conventional GCTB and malignant GCTB. Only 1-4% of GCTB is malignant. In this review article, we will discuss imaging findings at the time of diagnosis to guide the musculoskeletal radiologist in reporting these tumours. In addition, imaging for response evaluation after various treatment options will be addressed, such as surgery, radiotherapy, embolization and denosumab. Specific findings will be presented per imaging modality and illustrated by cases from our tertiary sarcoma referral center. Common postoperative and post radiotherapy findings in GCTB of the sacrum on MRI will be discussed.

Giant cell tumour of the sphenoid sinus: An unusual skull base tumour

1991 ◽  
Vol 105 (10) ◽  
pp. 855-857 ◽  
Author(s):  
David Uttley ◽  
Daniel J. Archer
Keyword(s):  
Skull Base ◽  
Giant Cell ◽  
Sphenoid Sinus ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
Surgical Strategy ◽  
Sphenoid Bone ◽  
Current Management ◽  
Skull Base Tumour ◽  
Giant Cell Tumours

AbstractAn unusual skull base tumour is presented. Intraoperative smears made the diagnosis and dictated a change in surgical strategy. Giant-cell tumours of the sphenoid bone are discussed, together with current management.

Trigger Wrist Caused by a Giant Cell Tumour of Tendon Sheath

1985 ◽  
Vol 10 (1) ◽  
pp. 121-123 ◽  
Author(s):  
N. SUEMATSU ◽  
T. HIRAYAMA ◽  
Y. TAKEMITSU
Keyword(s):  
Giant Cell ◽  
Medical Literature ◽  
Giant Cell Tumour ◽  
Flexor Tendon ◽  
Rare Condition ◽  
Tendon Sheath ◽  
Metacarpophalangeal Joint ◽  
Cell Tumour ◽  
Flexor Tendon Sheath ◽  
Trigger Wrist

Trigger wrist is a rare condition unlike the trigger finger of the metacarpophalangeal joint. This report describes a case of trigger wrist secondary to a giant cell tumour of the flexor tendon sheath. No previous reports are available in the medical literature.

scholarly journals Multiple systemic treatment options in a patient with malignant tenosynovial giant cell tumour

2020 ◽  
Vol 31 (1) ◽  
pp. 80-84 ◽  
Author(s):  
Sara Elena Rebuzzi ◽  
Massimiliano Grassi ◽  
Fabio Catalano ◽  
Michele Buscaglia ◽  
Rossella Bertulli ◽  
...  
Keyword(s):  
Giant Cell ◽  
Systemic Treatment ◽  
Giant Cell Tumour ◽  
Treatment Options ◽  
Cell Tumour ◽  
Tenosynovial Giant Cell Tumour

Silastic Replacement of Metacarpal after Resection of Giant Cell Tumour. A Case Report

2004 ◽  
Vol 29 (4) ◽  
pp. 402-405 ◽  
Author(s):  
A. CHATTERJEE ◽  
D. B. DHOLAKIA ◽  
S. V. VAIDYA
Keyword(s):  
Case Report ◽  
Giant Cell ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
Benign Lesions ◽  
Reconstructive Procedures ◽  
Metacarpal Head ◽  
Giant Cell Tumours ◽  
Silastic Prosthesis ◽  
Almost All

Giant cell tumours are aggressive lesions, albeit benign. Lesions in the hand, especially those arising from metacarpals require resection with adequate margins and definitive structural reconstruction to ensure preservation of hand architecture, function and cosmesis. Almost all the described reconstructive procedures require a stump of tumour free metacarpal base after resection, for reconstruction of the metacarpal. This report describes replacement of the entire metacarpal with a silastic prosthesis, in a case of giant cell tumour involving the entire metacarpal head and shaft to within 7 mm of the base.

Recurrent Metacarpal Giant Cell Tumour Treated by En Bloc Resection and Metatarsal Transfer

1998 ◽  
Vol 23 (2) ◽  
pp. 275-278 ◽  
Author(s):  
J. PARDO-MONTANER ◽  
A. PINA-MEDINA ◽  
M. BARCELO-ALCAIÑIZ
Keyword(s):  
Giant Cell ◽  
Giant Cell Tumour ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Cell Tumour ◽  
En Bloc ◽  
Giant Cell Tumours ◽  
Risk Of Malignancy

Recurrent giant-cell tumours of bone have a higher risk of malignancy than primary giant-cell tumours of bone, and giant-cell tumours of bone in the hand are more likely to recur than those that arise elsewhere. Therefore, en bloc resection and reconstruction, or amputation, have been the accepted treatments for recurrent giant-cell tumours of bone in the hand. We describe two cases of successful transplantion of a metatarsal to a metacarpal, which was the site of a recurrent giant-cell tumour. The patients had satisfactory results 3 years later without problems in the foot. En bloc resection of the tumour and reconstruction with an autograft should be considered in the treatment of recurrent giant cell tumour of the hand.

Giant cell tumour of the hyoid – first reported case

1999 ◽  
Vol 113 (6) ◽  
pp. 566-568 ◽  
Author(s):  
D. J. Commins ◽  
S. O'Malley ◽  
N. A. Athanasou ◽  
S. Jalloh
Keyword(s):  
Head And Neck ◽  
Giant Cell ◽  
Hyoid Bone ◽  
Giant Cell Tumour ◽  
Weight Bearing ◽  
Cell Tumour ◽  
Long Bones ◽  
Giant Cell Tumours

AbstractGiant cell tumours of bone are most commonly found in the epiphyses of weight-bearing long bones. They are rarely found in the head and neck and only 17 cases involving the laryngeal framework have been reported. To date, there have been no reports of a giant cell tumour arising from the hyoid bone. We present such a case which presented as a lump overlying the greater cornu of the hyoid, review the literature and discuss the management of this locally aggressive tumour.

Functional outcome of en bloc resection of a giant cell tumour of the distal radius and arthrodesis of the wrist and distal ulna using an ipsilateral double barrel segmental ulna bone graft combined with a modified Sauve-Kapandji procedure

2016 ◽  
Vol 42 (4) ◽  
pp. 377-381 ◽  
Author(s):  
W. Zhang ◽  
J. Zhong ◽  
D. Li ◽  
C. Sun ◽  
H. Zhao ◽  
...  
Keyword(s):  
Bone Graft ◽  
Giant Cell ◽  
Distal Radius ◽  
Giant Cell Tumour ◽  
Operative Procedure ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Cell Tumour ◽  
En Bloc ◽  
Level Of Evidence

Giant cell tumour of the distal radius is a locally aggressive lesion. In this study, we performed a wrist arthrodesis reconstruction with an ipsilateral double barrel segmental ulnar bone graft combined with a modified Sauve-Kapandji procedure for a giant cell tumour of the distal radius. From January 2007 to September 2013, we followed eight patients for a mean duration of 36 months. One patient developed a recurrence and was treated by amputation; the other seven patients achieved radiological union in about 8 months. There was no wrist instability, deformation or dislocation; the mean range of motion of the forearm achieved 75° of supination and 70° of pronation. The patients could recover reasonable grip strength. This new operative procedure can excise the tumour with a low rate of recurrence, fewer functional deficits and fewer complications than reported for other procedures. Level of evidence: IV, therapeutic

Giant Cell Tumours of the Hand

1996 ◽  
Vol 21 (5) ◽  
pp. 683-687 ◽  
Author(s):  
B. K. S. SANJAY ◽  
G. A. RAJ ◽  
D. A. YOUNGE
Keyword(s):  
Giant Cell ◽  
Giant Cell Tumour ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Cell Tumour ◽  
Fibular Graft ◽  
En Bloc ◽  
Giant Cell Tumours ◽  
En Bloc Excision ◽  
Bloc Excision

A study of seven cases of giant cell tumours of the hand is reported. All tumours were treated by an en bloc excision of the tumour or by whole ray resection. En bloc resection of the tumour and reconstruction with a fibular graft where necessary should be considered as the treatment of choice in giant cell tumour of the hand.

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