scholarly journals High prevalence of irritable bowel syndrome-type symptoms in microscopic colitis: implications for treatment

2018 ◽  
Vol 11 ◽  
pp. 175628481878360 ◽  
Author(s):  
John S. Kane ◽  
Andrew J. Irvine ◽  
Yannick Derwa ◽  
Olorunda Rotimi ◽  
Alexander C. Ford
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Psychological Health ◽  
Short Form ◽  
Demographic Data ◽  
Depression Scale ◽  
Microscopic Colitis ◽  
Irritable Bowel ◽  
The Impact

Background: Patients with microscopic colitis (MC) often present with abdominal pain and diarrhoea, and previous data suggest that there may be overlap between MC and irritable bowel syndrome (IBS). We evaluated the prevalence of IBS-type symptoms in patients with MC, and assess the impact of these symptoms on psychological health and quality of life. Methods: We conducted a cross-sectional survey of individuals with a histological diagnosis of MC, collecting demographic data, Rome III IBS-type symptoms, and mood, somatization, and quality of life data. Results: In total, 151 (31.6%) of 478 individuals with a new diagnosis of MC completed questionnaires, 52 (34.4%) of whom reported IBS-type symptoms. The commonest histological subtype was collagenous colitis (51.7%, n = 78), followed by lymphocytic colitis (39.1%, n = 59). Individuals with IBS-type symptoms had significantly higher levels of anxiety [Hospital Anxiety and Depression Scale (HADS) anxiety score 8.6 versus 5.1, p < 0.001], depression (HADS depression score 6.2 versus 3.6, p = 0.001), and somatoform-type behaviour (Patient Health Questionnaire 15 score 12.7 versus 8.0, p < 0.001) compared with individuals who did not. Those with IBS-type symptoms scored significantly worse across all domains of the 36-item Short Form questionnaire, except for physical functioning. Conclusions: More than one third of individuals with MC reported IBS-type symptoms, although whether this is due to ongoing inflammation is unclear. These individuals had higher levels of anxiety, depression, and somatization, and impaired quality of life. Identifying concomitant IBS in individuals with MC may have important implications for management decisions.

scholarly journals The impact of Irritable Bowel Syndrome on health-related quality of life: a Singapore perspective

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Yu Tien Wang ◽  
Hwee Yong Lim ◽  
David Tai ◽  
Thinesh L Krishnamoorthy ◽  
Tira Tan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Irritable Bowel ◽  
The Impact

scholarly journals The impact of irritable bowel syndrome on health-related quality of life in women with polycystic ovary syndrome

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Fatemeh Bazarganipour ◽  
Seyed-Abdolvahab Taghavi ◽  
Zatollah Asemi ◽  
Helen Allan ◽  
Zahra Khashavi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Polycystic Ovary ◽  
Health Related Quality ◽  
Ovary Syndrome ◽  
Related Quality ◽  
Health Related ◽  
Irritable Bowel ◽  
The Impact

scholarly journals Improved Health-Related Quality of Life After Surgical Management of Severe Refractory Constipation-Dominant Irritable Bowel Syndrome

2015 ◽  
Vol 100 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Jennifer Y. Lam ◽  
Biniam Kidane ◽  
Farouq Manji ◽  
Brian M. Taylor
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Surgical Management ◽  
Short Form ◽  
Health Related Quality ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related ◽  
Irritable Bowel

Abstract Irritable bowel syndrome (IBS) is the most common of the functional gastrointestinal disorders (FGIDs). Despite its prevalence and health-care costs, there are few effective therapies for patients with severe symptoms. Our objective was to determine whether surgical management would improve health-related quality of life (HRQOL) in severe refractory constipation-dominant FGIDs. From 2003 to 2005, 6 patients underwent total colectomy with end ileostomy or primary anastomosis. They completed Short Form 36 (SF-36) and IBS-36 questionnaires preoperatively and postoperatively. HRQOL was compared with age- and sex-matched Canadian norms using Welch's unpaired t test. Preoperative SF-36 physical and mental health summary scores were significantly lower than Canadian norms (P &lt; 0.0001), while postoperative scores were not significantly different than Canadian norms (P = 0.50 and P = 0.57, respectively). After surgical management, HRQOL in patients with severe constipation-dominant IBS improved from drastically below that of Canadian norms to a comparable level. This finding questions the convention of avoiding operations in IBS patients and demonstrates that surgical management may be suitable for the appropriately screened patient.

The impact of irritable bowel syndrome on health-related quality of life

2000 ◽  
Vol 119 (3) ◽  
pp. 654-660 ◽  
Author(s):  
Ian M. Gralnek ◽  
Ron D. Hays ◽  
Amy Kilbourne ◽  
Bruce Naliboff ◽  
Emeran A. Mayer
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Irritable Bowel ◽  
The Impact

scholarly journals TPH Gene Polymorphisms Are Associated With Disease Perception and Quality of Life in Women With Irritable Bowel Syndrome

2012 ◽  
Vol 16 (1) ◽  
pp. 95-104 ◽  
Author(s):  
Sang-Eun Jun ◽  
Ruth Kohen ◽  
Kevin C. Cain ◽  
Monica E. Jarrett ◽  
Margaret M. Heitkemper
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Gene Polymorphisms ◽  
Tryptophan Hydroxylase ◽  
Univariate Analysis ◽  
Gastrointestinal Symptoms ◽  
Tph2 Gene ◽  
Irritable Bowel ◽  
The Impact

The aims of this exploratory study were to examine whether tryptophan hydroxylase ( TPH) gene polymorphisms are associated with psychosocial factors in women with irritable bowel syndrome (IBS). TPH is the rate-limiting enzyme in the biosynthesis of serotonin and has two isoforms, TPH1 and TPH2. Four single nucleotide polymorphisms (SNPs) in the TPH1 gene and one SNP in the TPH2 gene were selected based on previous studies investigating associations between these SNPs and psychiatric or behavioral disorders. One hundred ninety-nine Caucasian women with IBS were included. Results of univariate analysis showed no association between TPH1and TPH2 gene SNPs and current level of psychological distress or psychiatric illness. However, TPH1 gene SNPs were associated with IBS-related cognitions (rs4537731 and rs21105) and quality of life (rs684302 and rs1800532), in particular the mental health and energy subscales. These associations were independent of the subjects’ levels of gastrointestinal symptoms. These results suggest that patients’ perception of their illness, and of the impact it has on their lives, may be subject to genetic influences, in this case sequence variants in TPH1. However, caution should be used in interpreting these results given the large number of hypothesis tests performed in this exploratory hypothesis-generating study, and the results should be considered tentative until confirmed in an independent sample.

Su2085 The Impact of Fear of GI Symptoms on Quality of Life Impairment Due to Irritable Bowel Syndrome

2014 ◽  
Vol 146 (5) ◽  
pp. S-542
Author(s):  
Jeffrey M. Lackner ◽  
Gregory D. Gudleski ◽  
Changxing Ma ◽  
Akriti Dewanwala ◽  
Bruce D. Naliboff
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Gi Symptoms ◽  
Irritable Bowel ◽  
The Impact

Coping Strategies and Irrational Beliefs as Mediators of the Health-Related Quality of Life Impairments in Irritable Bowel Syndrome

2015 ◽  
Vol 24 (2) ◽  
pp. 159-164 ◽  
Author(s):  
Mihaela Fadgyas Stanculete ◽  
Silviu Matu ◽  
Cristina Pojoga ◽  
Dan L. Dumitrascu
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Irrational Beliefs ◽  
Coping Mechanisms ◽  
Dysfunctional Attitudes ◽  
Brief Cope ◽  
Health Related ◽  
Irritable Bowel ◽  
The Impact

Background & Aims: Irritable bowel syndrome (IBS) is a chronic and disabling gastrointestinal disorder. Although considerable research has underlined the influence of coping mechanisms as the determinants of the quality of life (QOL), only limited data are available regarding the specific coping mechanisms used by IBS patients to manage illness in daily life. Irrational cognitions are known to emerge in stressful situations such as chronic diseases, and it has been proposed to have implications in the QOL. The aim of this study was to explore the relationship between coping styles and irrational beliefs in predicting the effects of IBS symptoms on the health-related QOL (HRQOL).Methods: A cross-sectional study was performed at two tertiary gastroenterology centers. A sample of 70 consecutive IBS patients and 55 healthy controls was studied. All participants completed the Brief Cope Inventory, the Dysfunctional Attitudes Scale, the Short-Form Health Survey and a demographic questionnaire.Results: All the HRQOL scores of the group with IBS were significantly lower than the HRQOL scores of the healthy group [Pillai's trace V = 0.404, F(8, 116) = 9.833, p < 0.001]. Irritable bowel syndrome patients used more problem-focused coping and avoidant-oriented coping than healthy subjects. The impact of IBS symptoms on HRQOL distress is mediated by irrational beliefs and avoidant oriented coping.Conclusions: Our findings highlight the role of irrational cognition and coping mechanisms in patients with IBS. The results underline the importance of the evaluation of psychological aspects of IBS with the possibility of having more tailored treatments for these patients.

The Impact of Mood and Somatization on Quality-of-life in Irritable Bowel Syndrome (IBS)

2010 ◽  
Vol 105 ◽  
pp. S490-S491
Author(s):  
Gregory Sayuk ◽  
Vladimir Kushnir ◽  
Amir Sabzpoushan ◽  
Prisca Kibe ◽  
Patrick Lustman ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Irritable Bowel ◽  
The Impact

scholarly journals Factors Affecting Quality of Life in Liver Transplant Candidates: An Observational Study

2021 ◽  
Vol 2 (1) ◽  
pp. 64-74
Author(s):  
Ana Isabel López-Lazcano ◽  
Hugo López-Pelayo ◽  
Antoni Gual ◽  
Anna Lligoña ◽  
Vanessa Vilas-Riotorto ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Observational Study ◽  
Liver Transplant ◽  
Short Form ◽  
Depression Scale ◽  
Psychosocial Interventions ◽  
Poor Hrqol ◽  
Transplant Candidates ◽  
The Impact

Health-related quality of life (HRQOL) before and after liver transplant (LT) is an important outcome in LT candidates as, in these patients, HRQOL is commonly impaired. However, evidence regarding factors that influence HRQOL in patients with end-stage liver disease is inconclusive. The aim of the present study was to identify factors associated with poor HRQOL. An observational study was conducted over LT candidates. The 36-item Short Form Health Survey (widely used to assess HRQOL) and the Hospital Anxiety and Depression Scale were administered to 211 patients during the pre-transplant assessment. Baseline demographic and clinical data were also collected. Multiple regression analysis was performed to investigate risk factors for poor HRQOL. Female sex (lower B = 7.99 95%C = 0.07–15.92, higher B = 18.09 95%CI = 7.56–28.62), encephalopathy (lower B = −9.45, 95%CI = −14.59–−4.31, higher B = −6.69, 95%CI = −13.13 to −0.25), higher MELD scores (lower B = −1.14, 95%CI = −1.67 to −0.61, higher B = −0.33, 95%CI = −0.65 to −0.12), anxiety (lower B = −3.04 95%C = −4.71 to −1.36, higher B = −1.93 95%CI = −3.39 to −0.47)and depression (lower B = −3.27 95%C = −4.46 to −2.08, higher B = −1.02 95%CI = −1.90 to −0.13) symptoms were associated to poorer HRQOL. Psychosocial interventions should be addressed to liver transplant candidates, especially to women, patients with anxiety, depression or episodes of encephalopathy, in order to prevent the impact that these conditions can have on HRQOL.

scholarly journals Low-FODMAP Diet and Its Role in Irritable Bowel Syndrome (IBS) Management

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Fábio Cardoso ◽  
Mónica Azevedo ◽  
Bruno Oliveira ◽  
Rui Poínhos ◽  
João Carvaho ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Emotional Disorders ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Inverse Association ◽  
Restricted Diet ◽  
Gi Symptoms ◽  
Irritable Bowel

AbstractIntroductionIrritable Bowel Syndrome (IBS) is a functional and multifactorial gastrointestinal disorder characterized by pain, abdominal distention and motility changes, currently diagnosed based on the Rome IV criteria. The efficacy of classic pharmacological, psychological and dietary treatments for this condition are generally low. The Fermentable Oligosaccharides, Disaccharides, Monosaccharides and Polyols (FODMAP) are short chain carbohydrates poorly absorbed at the intestinal level, fermentable by the microbiota and presumably involved in IBS-associated symptomatology.AimsTo evaluate the efficacy, feasibility and acceptability of a FODMAP-restricted feeding approach in the relief of symptomatology and in the improvement of the quality of life of patients with IBS, determining the reintroduction of the FODMAP food subgroup(s) involved in the symptom exacerbation.Materials and MethodsAfter assessing the existence of initial emotional disorders through the Hospital Anxiety and Depression Scale (HADS) and eating habits, through dietary history, patients diagnosed with IBS were put on a FODMAP-restricted diet for 6 weeks. During this period, the weekly evolution of symptom frequency was assessed. At the end, tests were undertaken to discover the global evolution of the symptoms through the Irritable Bowel Syndrome - Global Assessment Scale (IBS-GAI), the severity of symptomatology through the Irritable Bowel Syndrome - Severity Scoring System (IBS-SSS) and quality of life through Irritable Bowel Syndrome - Quality of Life (IBS-QoL).Subsequently, participants tested their tolerance to various FODMAP subtypes with weekly and isolated reintroduction of these in their diet.ResultsIn the 36 participants, with a mean age of 38.8 years, there was a reduction in the total consumption of FODMAP from 22.1 g to 2.1 g (p < 0.001). A moderate or substantial improvement in the IBS-GAI was observed in 88.9%. An average reduction of 235 points in the IBS-SSS (p < 0.001) and a mean increase of 28.7 in the IBS-QoL (p < 0.001) was achieved. The initial anxiety and depression levels were not associated with IBS-SSS and presented an inverse association with the IBS-QoL. There was significant improvement in all symptomatology during the 1st week of total FODMAP restriction, except for constipation with an amelioration observed at the 6st week. There was a frequency of intolerance ranging from 30.8% for fructans to 80.8% for lactose with the reintroduction of the FODMAP subtypes.ConclusionA FODMAP-restricted diet, implemented over a period of 6 weeks, is effective in reducing the severity and frequency of GI symptoms and improving the quality of life of portuguese patients with IBS.

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