scholarly journals Mechanisms underpinning the efficacy of faecal microbiota transplantation in treating gastrointestinal disease

2020 ◽  
Vol 13 ◽  
pp. 175628482094690 ◽  
Author(s):  
Jonathan P. Segal ◽  
Benjamin H. Mullish ◽  
Mohammed N. Quraishi ◽  
Tariq Iqbal ◽  
Julian R. Marchesi ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Gastrointestinal Disease ◽  
Full Potential ◽  
Faecal Microbiota ◽  
Therapeutic Tool ◽  
Faecal Microbiota Transplantation ◽  
Disease States ◽  
Clostridioides Difficile ◽  
Clostridioides Difficile Infection ◽  
Recommended Therapy

Faecal microbiota transplantation (FMT) is currently a recommended therapy for recurrent/refractory Clostridioides difficile infection (CDI). The success of FMT for CDI has led to interest in its therapeutic potential in many other disorders. The mechanisms that underpin the efficacy of FMT are not fully understood. Importantly, FMT remains a crucial treatment in managing CDI and understanding the mechanisms that underpin its success will be critical to improve its clinical efficacy, safety and usability. Furthermore, a deeper understanding of this may allow us to expose FMT’s full potential as a therapeutic tool for other disease states. This review will explore the current understanding of the mechanisms underlying the efficacy of FMT across a variety of diseases.

scholarly journals Faecal microbiota transplantation for recurrent Clostridioides difficile infection: An updated systematic review and meta-analysis

2020 ◽  
Vol 29-30 ◽  
pp. 100642
Author(s):  
Simon Mark Dahl Baunwall ◽  
Mads Ming Lee ◽  
Marcel Kjærsgaard Eriksen ◽  
Benjamin H. Mullish ◽  
Julian R. Marchesi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Faecal Microbiota ◽  
Faecal Microbiota Transplantation ◽  
Clostridioides Difficile ◽  
Clostridioides Difficile Infection

scholarly journals Faecal microbiota transplantation in Clostridioides difficile infection: real-life experience from an academic Italian hospital

2020 ◽  
Vol 13 ◽  
pp. 175628482093431
Author(s):  
Brigida Barberio ◽  
Sonia Facchin ◽  
Edoardo Mele ◽  
Renata D’Incà ◽  
Giacomo Carlo Sturniolo ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Laboratory Data ◽  
Real Life ◽  
Collagenous Colitis ◽  
Faecal Microbiota ◽  
Effective Treatment Option ◽  
Faecal Microbiota Transplantation ◽  
Clostridioides Difficile ◽  
Clostridioides Difficile Infection

Background: Faecal microbiota transplantation (FMT) is a reasonable therapeutic option for the treatment of Clostridioides difficile infection (CDI) recurrent and refractory (RCDI) to therapy, but little evidence on the long-term impact of this therapy is currently available in the literature. The aim of this study was to evaluate the efficacy and safety of FMT in recurrent and refractory CDI and the modifications of the recipient’s gut microbiota in the medium–long term. Methods: This prospective study collects the clinical and laboratory data of RCDI patients treated with FMT by colonoscopy from February 2016 to October 2019. Stool samples for metagenomic analysis were collected pre-FMT at 1 week and at 6 and 12–24 months post-FMT. Results: In the study period, 20 FMT procedures were performed on 19 patients. Overall, FMT was effective in 85% of treated patients. No serious adverse event was recorded. In the medium- to long-term follow up, a newly diagnosed case of collagenous colitis was observed. Post-FMT, significant changes in microbiota were observed, characterised by the transition from a low- to a greater-diversity profile. Therefore, FMT restores eubiosis and maintains it over time. Conclusion: FMT is a safe and effective treatment option in RCDI patients. This procedure induces profound microbiota changes that explain its high clinical efficacy.

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