Cytotoxic Bioactivity of Some Phenylpropanoic Acid Derivatives
2012 ◽
Vol 7
(10)
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pp. 1934578X1200701
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Keyword(s):
In this study, we synthesized a series of phenylpropanoic acid derivatives based on modifications at four selected points of the molecular scaffold. The in vitro antiproliferative activities of the compounds were examined in representative human solid tumor cell lines. A SAR was established pointing out the relevance of the substituents. The best activity profiles were obtained for the derivatives bearing more lipophilic esters (GI50 3.1-21 μM).
Keyword(s):
2010 ◽
Vol 20
(5)
◽
pp. 1504-1506
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Keyword(s):
2021 ◽
Keyword(s):
1996 ◽
Vol 224
(2)
◽
pp. 189-197
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Keyword(s):
2005 ◽
Vol 4
(12)
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pp. 1900-1911
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2004 ◽
Vol 2
(8)
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pp. 63
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Keyword(s):
2003 ◽
Vol 1
(5)
◽
pp. S291
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2009 ◽
Vol 189
(2)
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pp. 166-175
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1998 ◽
Vol 1
(1)
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pp. 29-51
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