scholarly journals A New Brominated Norsesquiterpene Glycoside From the Rhizomes of Acorus tatarinowii Schott

2021 ◽  
Vol 16 (2) ◽  
pp. 1934578X2199226
Author(s):  
Zhi-You Hao ◽  
Gang Ni ◽  
Dong Liang ◽  
Yan-Fei Liu ◽  
Chun-Lei Zhang ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Pc12 Cells ◽  
Absolute Configuration ◽  
Glucose Deprivation ◽  
Oxygen Glucose Deprivation ◽  
In Vitro Tests ◽  
Nuclear Magnetic Resonance Spectra ◽  
Acorus Tatarinowii

A new brominated norsesquiterpene glycoside, acoruside (1), has been isolated from the rhizomes of Acorus tatarinowii Schott, together with 8 known compounds (2-9). Their structures were elucidated mainly based on 1-dimensional (1D) and 2D nuclear magnetic resonance spectra. The absolute configuration of compound 1 was determined by comparing its experimental and calculated electronic circular dichroism spectra. The in vitro tests indicated that at 10 µM, compounds 2, 3, and 4 aggravated serum deprivation injuries of PC12 cells, compound 2 aggravated rotenone-induced injuries of PC12 cells, and compounds 3 and 4 aggravated the oxygen-glucose deprivation-induced injuries of PC12 cells.

A Red-Shifted Chlorophyll: Fig. 1

Science ◽  
2010 ◽  
Vol 329 (5997) ◽  
pp. 1318-1319 ◽  
Author(s):  
Min Chen ◽  
Martin Schliep ◽  
Robert D. Willows ◽  
Zheng-Li Cai ◽  
Brett A. Neilan ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Infrared Region ◽  
Energy Transduction ◽  
Oxygenic Photosynthesis ◽  
The Past ◽  
Nuclear Magnetic Resonance Spectra ◽  
Oxygenic Phototrophs ◽  
Chlorophyll F

Chlorophylls are essential for light-harvesting and energy transduction in photosynthesis. Four chemically distinct varieties have been known for the past 60 years. Here we report isolation of a fifth, which we designate chlorophyll f. Its in vitro absorption (706 nanometers) and fluorescence (722 nanometers) maxima are red-shifted compared to all other chlorophylls from oxygenic phototrophs. On the basis of the optical, mass, and nuclear magnetic resonance spectra, we propose that chlorophyll f is [2-formyl]-chlorophyll a (C55H70O6N4Mg). This finding suggests that oxygenic photosynthesis can be extended further into the infrared region and may open associated bioenergy applications.

Metabolites of Lachnellula fuscosanguinea (Rehm). Part 2. The structure of lachnellulone

1988 ◽  
Vol 66 (3) ◽  
pp. 506-512 ◽  
Author(s):  
William A. Ayer ◽  
J. Daniel Figueroa Villar ◽  
Barbara S. Migaj
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Absolute Configuration ◽  
Mass Spectra ◽  
Antifungal Metabolite ◽  
X Ray ◽  
Crystallographic Study ◽  
Nuclear Magnetic Resonance Spectra ◽  
The Absolute ◽  
Nuclear Magnetic

Lachnellulone, an antifungal metabolite produced by Lachnellula fuscosanguinea (Rehm) Dennis is shown to possess structure 8. The structure was determined by consideration of the ultraviolet, infrared, 1H and 13C nuclear magnetic resonance, and mass spectra of 8 and its derivatives and was confirmed by an X-ray crystallographic study of lachnellulone p-nitrobenzoate. In solution lachnellulone undergoes facile isomerization to isolachnellulone (9a), which explains the observed mutarotation of 8. The 13C nuclear magnetic resonance spectra of lachnellulone and the related lachnelluloic acid (1) are discussed in some detail. The absolute configuration of lachnellulone has not been determined.

scholarly journals N-[7-Chloro-4-[4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl] quinoline]-acetamide

Molbank ◽  
10.3390/m1213 ◽  
2021 ◽  
Vol 2021 (2) ◽  
pp. M1213
Author(s):  
Paolo Coghi ◽  
Jerome P. L. Ng ◽  
Ali Adnan Nasim ◽  
Vincent Kam Wai Wong
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Quantum Coherence ◽  
Biologically Active ◽  
Proton Nuclear Magnetic Resonance ◽  
Dipolar Cycloaddition ◽  
Heteronuclear Single Quantum Coherence ◽  
Pharmacokinetic Properties ◽  
Nuclear Magnetic

The 1,2,3-triazole is a well-known biologically active pharmacophore constructed by the copper-catalyzed azide–alkyne cycloaddition. We herein reported the synthesis of 4-amino-7-chloro-based [1,2,3]-triazole hybrids via Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition of 4-azido-7-chloroquinoline with an alkyne derivative of acetaminophen. The compound was fully characterized by Fourier-transform infrared (FTIR), proton nuclear magnetic resonance (1H-NMR), carbon-13 nuclear magnetic resonance (13C-NMR), heteronuclear single quantum coherence (HSQC), ultraviolet (UV) and high-resolution mass spectroscopies (HRMS). This compound was screened in vitro with different normal and cancer cell lines. The drug likeness of the compound was also investigated by predicting its pharmacokinetic properties.

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