Comorbidities Known to Affect Physical Function Negatively Impact Baseline Health-Related Quality-of-Life in Patients With Chronic Rhinosinusitis

2021 ◽  
pp. 194589242110136
Author(s):  
Amarbir S. Gill ◽  
Shaelene Ashby ◽  
Gretchen M. Oakley ◽  
Toby O. Steele ◽  
Dennis Menjivar ◽  
...  

Background Medical comorbidities are commonly encountered in chronic rhinosinusitis (CRS) and may impact both physical function and patient reported health-related quality-of-life (HRQOL). The functional comorbidity index (FCI) is designed to elucidate the role of comorbidities on functional prognosis. The objective of this study was to understand the impact of comorbidities known to impact physical function on baseline HRQOL using the FCI. Methodology: Patients meeting diagnostic criteria for CRS were prospectively enrolled in a cross-sectional study. Responses from the Sinonasal Outcomes Test-22 (SNOT-22), a measure of patient HRQOL, as well as the Lund-Kennedy and Lund-Mackay scores were recorded at enrollment. FCI was calculated retrospectively using the electronic medical record. Information was collected and compared for patients without (CRSsNP) and with nasal polyps (CRSwNP) using chi-square and t-tests. Spearman’s correlations, followed by multivariate regression analysis, were used to assess the association between FCI and SNOT-22 scores. Results One hundred and three patients met inclusion criteria for analysis. There were no significant differences in age, gender, and SNOT-22 scores between patients with CRSsNP and those with CRSwNP. FCI was significantly and independently associated with worse SNOT-22 scores ( P = .012). FCI did not correlate with endoscopy and computed tomography scores. The mean FCI for patients with CRSsNP and CRSwNP was 2.02 and 2.24, respectively, and did not differ significantly between the two cohorts ( P = .565). Conclusions Major medical comorbidities known to affect physical function are associated with worse SNOT-22 scores in patients with CRS as measured by the FCI.

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
A. L. Barcenilla-Wong ◽  
J. S. Chen ◽  
M. J. Cross ◽  
L. M. March

This prospective study aimed to examine the impact of fracture incidence on health-related quality of life (HRQOL) among postmenopausal women. Study subjects were Australian female community-dwellers in the Global Longitudinal Study of Osteoporosis in Women (GLOW). Self-administered questionnaires were collected annually from 2007 to 2010. Outcomes were the Medical Outcomes Study Short Form-36 (SF-36 physical function (SF36PFS) and vitality (SF36VS) scores), European Quality of Life (EQ-5D), and self-reported general health (GH) of excellent/good. Questionnaires were divided into prior to, the 1st, the 2nd, and the 3rd year after incident fracture assessments. Generalized linear models with generalised estimating equations (GEE) were employed for the analysis. The 2,872 participants (age: median 65; interquartile range 60–73 years) provided a total of 10,436 assessments including 266, 165 and 76 assessments for the 1st, the 2nd, and the 3rd year after incident fracture, respectively. Multivariate adjustments showed reductions in HRQOL measures peaking at the 1st year for SF36VS (coefficient −3.0; 95% CI: −5.1, −0.8) and EQ-5D (coefficient −0.03; 95% CI: −0.06, −0.00) and at the 2nd year for SF36PFS (coefficient −3.0; 95% CI: −5.6, −0.5) and GH (odds ratio 0.92; 95% CI: 0.70, 1.19). Fracture incidence reduced HRQOL including vitality and physical function among relatively young, healthy postmenopausal women and the reduction in European Quality of Life measure was clinically important.


2021 ◽  
Vol 15 ◽  
Author(s):  
Coeli Regina Carneiro Ximenes ◽  
Anke Bergmann ◽  
Jurema Telles de Oliveira Lima ◽  
Arlene Santos Cavalcanti ◽  
Murilo Carlos Amorim de Britto ◽  
...  

OBJECTIVE: To evaluate the impact of age in health-related quality of life (HRQoL) in older adults with cancer. METHODS: This was a cross-sectional study of 608 older adults diagnosed with cancer. Age groups were considered an independent variable. For the analysis of HRQoL, the mean scores of age groups were compared by analysis of variance and the Scheffé comparison test. For measuring the association between age and HRQoL, we used simple and multiple linear regression analyses. RESULTS: Cognitive function showed the highest scores (average 87.94 ± 26.87), while physical function showed the lowest ones (68.04 ± 28.63). The highest symptom score was observed for financial difficulties (34.21 ± 39.06), followed by pain (29.47 ± 33.92) and insomnia (28.51 ± 37.03). After adjustment, we observed a decrease in physical function (p = 0.028) and an improvement in emotional function (p = 0.003) with increasing age. Conclusions: In older patients with cancer, age negatively impacted physical function and positively impacted emotional function.


Author(s):  
Pablo Monteagudo ◽  
Ainoa Roldán ◽  
Ana Cordellat ◽  
Mari Carmen Gómez-Cabrera ◽  
Cristina Blasco-Lafarga

The present study aimed to analyze the impact of overground walking interval training (WIT) in a group of sedentary older adults, comparing two different dose-distributions. In this quasi-experimental and longitudinal study, we recruited twenty-three sedentary older adults (71.00 ± 4.10 years) who were assigned to two groups of WIT. The continuous group (CWIT) trained for 60 min/session in the morning, while the accumulated group (AWIT) performed the same duration and intensity of exercise, but it was distributed twice a day (30 min in the morning and 30 more in the afternoon). After 15 weeks of an equal external-load training (3 days/week), Bonferroni post-hoc comparisons revealed significant (p < 0.050) and similar large improvements in both groups in cardiorespiratory fitness and lower limb strength; even larger gains in preferred walking speed and instrumental daily life activity, which was slightly superior for CWIT; and improvements in agility, which were moderate for CWIT and large for AWIT. However, none of the training protocols had an impact on the executive function in the individuals, and only the AWIT group improved health-related quality of life. Although both training protocols induced a general significant improvement in physical function in older adults, our results showed that the accumulative strategy should be recommended when health-related quality of life is the main target, and the continuous strategy should be recommended when weakness may be a threat in the short or medium term.


2009 ◽  
Vol 137 (9-10) ◽  
pp. 470-474 ◽  
Author(s):  
Jelena Dotlic ◽  
Jelena Marinkovic

Introduction The need for assessing the quality of life in chronic rhinosinusitis is emphasized by the medical, social and economic importance of this pathological condition. Questionnaires have been employed in majority of studies while there are no available data that Q method has been used for quality of life research in chronic rhinosinusitis up to the present. Objective The aim of this study was to identify, group and analyze subjective perception of the impact of the disease on health-related quality of life in patients with chronic rhinosinusitis. Methods The study involved 36 consecutive patients of both sexes, older than 10 years of age, diagnosed with chronic rhinosinusitis in the tertiary health clinic in three successive weeks. They were selected for medicamentous treatment. Health-related quality of life was assessed by Q method. Through 34 representative statements, which were sorted by the examinees related to subjective priorities, 10 key quality of life domains were examined. The data were processed by factor analysis employing specialized software package PQMethod. Results Analyzing individual opinions of the examinees, five different opinion-types (factors) on the impact of chronic rhinosinusitis on quality of life were demonstrated. They were marked numerically and descriptively according to dominant characteristics of the group: Factor 1 - stable group (47.2% of individuals), Factor 2 - symptomatic group (11.1% of individuals), Factor 3 - mental group (5.6% of individuals), Factor 4 - physical group (11.1% of individuals) and Factor 5 - optimistic group (25.0% of individuals). Each group was systematically analyzed. Conclusion Majority of patients with chronic rhinosinusits (72.2%) were found to be satisfied with the quality of life, while just a small number (5.6%) heavily bore the illness which especially jeopardised their mental health. This study demonstrates the strength of Q method in analyzing and categorizing subjectivity and offers quality practical information which enables a more comprehensive approach and more adequate intervention in patients with chronic rhinosinusitis.


2010 ◽  
Vol 19 (3) ◽  
pp. 237-248 ◽  
Author(s):  
Alison R. Snyder ◽  
Jessica C. Martinez ◽  
R. Curtis Bay ◽  
John T. Parsons ◽  
Eric L. Sauers ◽  
...  

Context:Patient-oriented outcome measures such as the Medical Outcomes Short Form (SF-36) and the Pediatric Outcomes Data Collection Instrument (PODCI) are important tools for determining the impact of events like sport-related injury on health-related quality of life (HRQoL). Unfortunately, there are no published studies using these instruments that compare adolescent athletes with their nonathlete peers, making interpretations of these measures in this population difficult.Objective:To compare HRQoL in adolescent athletes and nonathletes using 2 common instruments.Design:Cross-sectional.Setting:7 high schools.Participants:219 athletes and 106 nonathletes.Intervention:None.Main Outcome Measures:The SF-36 and the PODCI were completed in a counterbalanced manner during 1 session. Dependent variables included the 8 subscale and 2 composite scores of the SF-36 and the 5 subscale scores and 1 global score of the PODCI.Results:On the SF-36, athletes reported higher scores on the physical function, general health, social functioning, and mental health subscales and the mental composite score and lower scores on the bodily pain subscale than nonathletes. On the PODCI, athletes reported higher scores on the sport and physical function and happiness subscales and lower scores on the pain/comfort subscale.Conclusions:Athletes reported higher scores on a number of SF-36 and PODCI subscales related to mental, emotional, and physical well-being than nonathletes. Our findings suggest that athletic involvement may be a benefit to the overall health status of adolescents and imply that athletes may be a distinct adolescent group requiring their own normative values when using the SF-36 and PODCI.


Author(s):  
Phillippa Carnemolla ◽  
Catherine Bridge

The multi-dimensional relationship between housing and population health is now well recognised internationally, across both developing and developed nations. This paper examines a dimension within the housing and health relationship – accessibility – that to date has been considered difficult to measure. This paper reports on the mixed method results of larger mixed-method, exploratory study designed to measure the impact of home modifications on Health-Related Quality of Life, supported by qualitative data of recipients’ experiences of home modifications. Data was gathered from 157 Australian HACC clients, who had received home modifications. Measurements were taken for both before and after home modifications and reveal that home modifications were associated with an average 40% increase in Health-Related Quality of Life levels. The qualitative results revealed that participants positively associated home modifications across six effect themes: increased safety and confidence, improved mobility at home, increased independence, supported care-giving role, increased social participation, and ability to return home from hospital. This exploratory research gives an insight into the potential for accessible architecture to impact improvements in community health and wellbeing.


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