scholarly journals Giant cell tumor of bone: Unusual features of a rare tumor

Rare Tumors ◽  
2019 ◽  
Vol 11 ◽  
pp. 203636131987889 ◽  
Author(s):  
Ziyad M Mohaidat ◽  
Hisham Z Al-jamal ◽  
Audai M Bany-Khalaf ◽  
Ahmad M Radaideh ◽  
Ziad A Audat
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Malignant Transformation ◽  
Fatal Outcome ◽  
Cell Tumor ◽  
Anatomical Location ◽  
Histopathological Diagnosis ◽  
Intralesional Curettage ◽  
Primary Tumors

Giant cell tumor of bone is a benign tumor with an aggressive behavior. Its typical subarticular location and high recurrence risk can be associated with significant morbidity. Although benign, it can rarely metastasize especially to the lungs. Also, it can be multicentric in less than 1% of patients. Late malignant transformation, although rare, can occur with a very poor prognosis. This series reports on these unusual and challenging features and management considerations of giant cell tumor of bone. This retrospective study included review of the medical records of patients with a confirmed histopathological diagnosis of giant cell tumor of bone. A total of 25 patients (16 females and 9 males) with a mean age of 34.5 years were included; 22 had primary tumors, while 3 were referred with recurrent tumors. Pain was the most common presenting symptom. Most patients had grade III tumors. Tumors around the knee were the most common. Multicentric tumors were detected in three patients. Twenty-three patients (20 primary giant cell tumor of bone and 3 with recurrence) received treatment. Most patients (15/23) were treated with intralesional curettage with or without adjuvants. Seven patients had wide excision. Recurrence was seen in 45% (9/20) of primary giant cell tumor of bone especially with difficult anatomical locations. Most recurrences occurred more than 4 years after treatment. Pulmonary nodules were detected in four patients; two of them showed resolution during follow-up. One patient developed secondary sarcoma transformation with a fatal outcome. Giant cell tumor of bone was more common in females. Long bones were more affected, especially around the knee. Intralesional curettage was the most frequently used treatment. Recurrence was associated with inadequate tumor resection (especially in difficult anatomical location), younger age, male gender, and advanced local tumor grade. Denosumab can be used in the treatment of pulmonary metastasis, multicentric and recurrent giant cell tumor of bone. Due to late recurrence and malignant transformation, a prolonged follow-up is warranted.

scholarly journals Giant cell tumor distal end radius: resection and reconstruction using proximal fibular graft

2021 ◽  
Vol 7 (2) ◽  
pp. 409
Author(s):  
Rahul Bharadwaj ◽  
Vipin Sharma ◽  
Narinder Singh ◽  
Narinder Singh
Keyword(s):  
Range Of Motion ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Giant Cell Tumour ◽  
Wrist Joint ◽  
Cell Tumor ◽  
Fibular Graft ◽  
Primary Tumors ◽  
One Year

<p>Giant cell tumour forms 4% of all primary tumors. GCT distal radius is very rare. Current study presents a case of a 27 year female who was managed by wide excision and reconstruction with ipsilateral fibula. At one year follow up, patient had excellent range of motion at wrist joint and hand.</p>

scholarly journals Giant cell tumor of the capitate: an unusual case with 10 years follow-up

SICOT-J ◽  
2015 ◽  
Vol 1 ◽  
pp. 18 ◽  
Author(s):  
Serda Duman ◽  
Hakan Sofu ◽  
Yalkin Camurcu ◽  
Sarper Gursu ◽  
Ramadan Oke
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Unusual Case ◽  
Cell Tumor

scholarly journals A Systematic Review and Meta-Analysis of En-Bloc vs Intralesional Resection for Giant Cell Tumor of Bone of the Distal Radius

2013 ◽  
Vol 7 (1) ◽  
pp. 103-108 ◽  
Author(s):  
Theresa J.C Pazionis ◽  
Hussain Alradwan ◽  
Benjamin M Deheshi ◽  
Robert Turcotte ◽  
Forough Farrokhyar ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Distal Radius ◽  
Wrist Joint ◽  
Meta Analysis ◽  
En Bloc Resection ◽  
Cell Tumor ◽  
En Bloc ◽  
Intralesional Curettage ◽  
Functional Benefit

Introduction: Surgical management of Giant Cell Tumor of Bone of the distal radius (GCTDR) remains controversial due to risk of local recurrence (LR) offset by functional limitations which result from en-bloc resection. This study aims to determine the oncologic and functional outcomes of wide excision (WE) vs intralesional curettage (IC) of GCTDR. Methods: A complete search of the applicable literature was done. Included studies reported on patients from the same cohort who were surgically treated for GCTDR with WE or IC. Two reviewers independently assessed all papers. The primary outcome measure was LR. Results: One-hundred-forty-one patients from six studies were included: 60 treated with WE, and 81 with IC. Five WE patients (8%) suffered LR whereas 25 IC patients (31%) did. The odds of LR were three times less in the WE group vs the IC group. MSTS1993 scores, where available, were on average 'good' with WE and 'excellent' with IC. Conclusions: Within statistical limitations the data support an attempt, where feasible, at wrist joint preservation and superior function with IC. Intralesional curettage is reasonable when the functional benefit outweighs the risk of recurrence as is the case in many cases of GCT of the distal radius.

scholarly journals Giant Cell Tumor of Bone: Oncological and Functional Results of Long-term Follow-up

1998 ◽  
Vol 28 (5) ◽  
pp. 323-328 ◽  
Author(s):  
Y. Oda ◽  
H. Miura ◽  
M. Tsuneyoshi ◽  
Y. Iwamoto
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Functional Results ◽  
Cell Tumor ◽  
Long Term Follow Up

scholarly journals A Case Report of Giant Cell Tumor of Proximal Fibula in Children

2020 ◽  
Vol 4 (1) ◽  
pp. 64-67
Author(s):  
Sushil Adhikari ◽  
Arun Sigdel ◽  
Rajesh Kumar Sah ◽  
Luna Devkota
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Long Bone ◽  
Lytic Lesion ◽  
Radiographic Appearance ◽  
X Ray ◽  
Proximal Fibula ◽  
Aggressive Tumor

Giant cell tumour (GCT) is histopathologically benign tumor of long bone particularly in distal femur and the proximal tibia. It commonly occurs in adults of age 20-40 years but rare in children. GCT is considered to be locally aggressive tumor and tendency of recurrence is higher even after surgery. The clinical features are nonspecific, the principle symptoms are pain, swelling and limiting adjacent joint movements. Diagnosis is based on the radiographic appearance and histopathological findings .In our case X-ray showed ill defined lytic lesion on proximal fibula with cortical thinning and MRI finding revealed expansile lyticlesion in meta-epiphysis of right fibula 16×16×28mm adjacent to growth plate with fluid level. The sclerotic rim appears hypo intense on T1 & hyper intense on T2. Core needle biopsy showed giant cell tumor on proximal fibula. Considering the risk of recurrence wide local excision was done. Management of GCT of proximal fibula in young patient is critical for preventing recurrence and enhancing functional outcomes by saving adjacent anatomical structure. No evidence of local recurrence and metastasis was found in 24 months of follow up.

Malignant Transformation of Giant Cell Tumor Affecting the Lower Lip

2015 ◽  
Vol 120 (2) ◽  
pp. e68
Author(s):  
JORGE ESQUICHE LEÓN ◽  
LUCIANA YAMAMOTO DE ALMEIDA ◽  
MARISOL MARTÍNEZ MARTÍNEZ ◽  
FERNANDA DOS SANTOS MOREIRA ◽  
ALÍCIA RUMAYOR PIÑA ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Malignant Transformation ◽  
Cell Tumor ◽  
Lower Lip

GIANT CELL TUMOR OF TENDON SHEATH MIMICKING PYOGENIC GRANULOMA IN THE INDEX FINGER PULP: A CASE REPORT

Hand Surgery ◽  
2012 ◽  
Vol 17 (01) ◽  
pp. 125-127
Author(s):  
J. Terrence Jose Jerome ◽  
Kumar Venkatesan ◽  
Amarnath G ◽  
Usha Rani ◽  
Rohini Sridhar
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Clinical Presentation ◽  
Index Finger ◽  
Pyogenic Granuloma ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
Complete Excision ◽  
Study Base

We report a 75-year-old man who presented with a painless friable mass in the index finger pulp mimicking pyogenic granuloma. Complete excision of the mass was done. The radiological and the histopathological findings suggested giant cell tumor of the tendon sheath. The patient had no recurrence at the end of a two-year follow-up. This unusual clinical presentation of the giant cell tumor of the tendon sheath was our study base and adds up to its variant presentation in the literature.

Primary malignant transformation of giant cell tumor of bone

2007 ◽  
Vol 62 (3) ◽  
pp. 89-93 ◽  
Author(s):  
Eric J. Heffernan ◽  
Paul J. O'Sullivan ◽  
Manoochehr Adibeig ◽  
Luck J. Louis ◽  
Anthony G. Ryan ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Malignant Transformation ◽  
Cell Tumor

scholarly journals Ten-Year Follow-Up of Desarthrodesis of the Knee Joint 41 Years after Original Arthrodesis for a Bone Tumor

2015 ◽  
Vol 2015 ◽  
pp. 1-6
Author(s):  
Ahmed Hamed Kassem Abdelaal ◽  
Norio Yamamoto ◽  
Katsuhiro Hayashi ◽  
Akihiko Takeuchi ◽  
Shinji Miwa ◽  
...  
Keyword(s):  
Knee Joint ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Tumor Resection ◽  
Cell Tumor ◽  
Joint Surface ◽  
Knee Arthrodesis ◽  
Extensive Resection ◽  
Complication Risk

Introduction. The main indication for knee arthrodesis in tumor surgery is a tumor that requires an extensive resection in which the joint surface cannot be preserved. We report a patient that had knee desarthrodesis 41 years after giant cell tumor resection followed by a knee arthrodesis. This is the longest reported follow-up after desarthrodesis and conversion to total knee arthroplasty (TKA), almost ten years.Case Report. A 71-year-old man with a distal femoral giant cell tumor had undergone a resection of the distal femur and knee arthrodesis using Kuntscher nail in 1962. In July 2003 he experienced gradually increasing pain of his left knee. We performed a desarthrodesis and conversion to TKA in 2005. The postoperative period passed uneventfully as his pain and gait improved, with gradually increasing range of motion (ROM) and no infection. He now walks independently, with no brace or contractures.Conclusion. Desarthrodesis of the knee joint and conversion to TKA are a difficult surgical choice with a high complication risk. However, our patient’s life style has improved, he has no pain, and he can ascend and descend stairs more easily. The surgeon has to be very meticulous in selecting a patient for knee arthrodesis and counseling them to realize that their expectations may not be achievable.

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