Chronic annular pustular psoriasis resembling subcorneal pustular dermatosis: A case report

Generalized pustular psoriasis and subcorneal pustular dermatosis are generalized pustular dermatoses that are characterized by the subcorneal accumulation of neutrophils. Careful examination is important in distinguishing these diseases for appropriate management. Patients with acute generalized pustular psoriasis are systemically unwell with discrete pustules as opposed to the chronicity and associated hypopyon lesions in subcorneal pustular dermatosis. Generalized pustular psoriasis lesions demonstrate psoriasiform changes on histology and the increased expression of Th17 cytokines. We describe a middle-aged woman presenting with chronic annular generalized pustular psoriasis, initially mistaken for subcorneal pustular dermatosis due to their clinical and histological semblance. The patient had recurrent skin disease for 6 years despite conventional therapy of oral retinoid, immunosuppressant and biologic therapy. Complete and persistent clearance of her skin lesions was achieved with secukinumab, an interleukin 17A inhibitor.

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Successful treatment with interleukin-17A antagonists of generalized pustular psoriasis in patients without IL36RN mutations

The Journal of Dermatology ◽

10.1111/1346-8138.14318 ◽

2018 ◽

Vol 45 (7) ◽

pp. 850-854 ◽

Cited By ~ 10

Author(s):

Dagmar Wilsmann-Theis ◽

Lisa Marie Schnell ◽

Veronika Ralser-Isselstein ◽

Thomas Bieber ◽

Michael P. Schön ◽

...

Keyword(s):

Successful Treatment ◽

Pustular Psoriasis ◽

Interleukin 17A ◽

Generalized Pustular Psoriasis

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Long-term maintenance therapy with Cyclosporine A in adults with generalized pustular psoriasis

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v9i5.3535 ◽

2019 ◽

Vol 9 (5) ◽

pp. 19-21 ◽

Cited By ~ 1

Author(s):

Kamel El-Reshaid ◽

Al-Bader Shaima

Keyword(s):

Cyclosporine A ◽

Light Exposure ◽

Skin Lesions ◽

Pustular Psoriasis ◽

Gingival Hyperplasia ◽

Immune Mediated ◽

Generalized Pustular Psoriasis ◽

Liver And Kidney

Generalized pustular psoriasis (GPP) is a rare and serious immune-mediated skin disorder that is characterized by a widespread eruption of sterile and subcorneal pustules. In the present study we investigated the efficacy of Cyclosporine A (Cy A) in treatment of 9 adults with drug-refractory GPP viz. topical Corticosteroids, retinoids, methotrexate and narrow-band ultraviolet light exposure (UVB). Initially; they were resuscitated as burn patients. Cy A was administered on day 1 at a dose of 100 mg twice daily either in the form of syrup or Neoral capsules. In most patients, skin lesions had healed by 6 weeks and the dose of Cy A was reduced to minimum to prevent further recurrence. Seven patients had required 50 mg twice daily and 2 were controlled with 50 mg am and 25 mg pm. On follow up, there was no serious relapse, liver and kidney disease. Minor complications included; hirsutism and dark skin (n: 5) and gingival hyperplasia (n: 2). Trial to replace Cy A with Tacrolimus (Prograf) failed to maintain remission. In conclusion; Cy A is a safe and effective treatment for GPP. Keywords: Cyclosporin A, treatment, psoriasis, pustular.

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An Unusual Tumor of the Ear: Pilomatricoma in a Middle-Aged Woman

Case Reports in Otolaryngology ◽

10.1155/2019/4975216 ◽

2019 ◽

Vol 2019 ◽

pp. 1-4

Author(s):

Akira Inagaki ◽

Yoriko Yamashita ◽

Yusuke Mori ◽

Erika Takeuchi ◽

Kyosuke Asaoka ◽

...

Keyword(s):

Benign Tumor ◽

Clinical Presentation ◽

Skin Lesions ◽

Skin Nodule ◽

Aged Woman ◽

Superficial Skin ◽

Atypical Clinical Presentation ◽

Middle Aged Woman ◽

Rare Site ◽

Slow Growing

Pilomatricoma is a benign tumor arising from hair follicle matrix cells, presenting as an asymptomatic, firm, slow growing, mobile, superficial skin nodule typically in children. This lesion with an atypical clinical presentation is frequently misdiagnosed as other skin lesions and even as malignant entities regardless of detailed cytological, imaging examinations; the site of occurrence is one of the keys to accurate diagnosis. Here, we present a case of pilomatrixoma involving the ear, the cymba conchae of the auricle, which is an extremely rare site for the lesion in a 52-year-old woman. The present case suggests that this benign tumor needs to be included in the differential diagnosis in patients who present with an atypical auricular lesion.

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Eosinophilic pleural effusion: A case and a review

The Southwest Respiratory and Critical Care Chronicles ◽

10.12746/swrccc.v8i33.633 ◽

2020 ◽

Vol 8 (33) ◽

pp. 40-46

Author(s):

Mark Lacy

Keyword(s):

Pleural Effusion ◽

Skin Lesions ◽

Pleural Effusions ◽

Middle Aged ◽

Therapeutic Challenge ◽

Case Summary ◽

Aged Woman ◽

Middle Aged Woman ◽

Eosinophilic Pleural Effusion

A previously healthy middle-aged woman presented with evanescent skin lesions and bilateral pleural effusions with an eosinophilic predominance. Following this case summary, a description of eosinophilic pleuritis, the epidemiology, etiologic considerations, and selected therapies for this syndrome are discussed. Eosinophilic pleural effusion is caused by myriad etiologies and is a therapeutic challenge. Keywords: pleural effusion, eosinophilic effusion, dermatitis

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Elderly-Onset Generalized Pustular Psoriasis without a Previous History of Psoriasis Vulgaris

Case Reports in Dermatology ◽

10.1159/000438505 ◽

2015 ◽

Vol 7 (2) ◽

pp. 187-193 ◽

Cited By ~ 1

Author(s):

Takayuki Aizu ◽

Akinobu Matsui ◽

Noriko Takiyoshi ◽

Eijiro Akasaka ◽

Takahide Kaneko ◽

...

Keyword(s):

Psoriasis Vulgaris ◽

Clinical Course ◽

Previous History ◽

Neutrophil Infiltration ◽

Skin Lesions ◽

Pustular Psoriasis ◽

Whole Body ◽

Older Individuals ◽

Generalized Pustular Psoriasis ◽

History Of

Generalized pustular psoriasis (GPP) is characterized by sudden fever and extensive erythema with pustules and occurs in patients with or without preceding psoriasis vulgaris. We report an 83-year-old man showing irregularly shaped erythema with pustules on the trunk and extremities. He initially had no fever and came to our clinic a few days after the onset of the skin lesions because of high fever and general malaise. We found an extension and new development of erythema and pustules on the whole body. The patient also manifested night delirium. Histological examination revealed neutrophil infiltration into the upper epidermis, which formed a spongiform pustule of Kogoj. Pustular fluid cultures were negative for bacteria. We diagnosed GPP without preceding psoriasis vulgaris. Mutation analysis revealed no significant mutations in IL36RN and CARD14. Previous reports indicated that onset of GPP at the age of 83 years is definitely rare. In older individuals, general disease characteristics include an atypical clinical course, an especially slow appearance and cure, and mental disorder. Our case also revealed such characteristics. Thus, it is necessary to be aware of the clinical course and mental problems in elderly patients with GPP.

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CHROMOBLASTOMYCOSIS: A REPORT OF 2 CASES WITH LITERATURE REVIEW

10.36106/gjra/9804839 ◽

2020 ◽

pp. 2-4

Author(s):

Kuladeepa Ananda Vaidya K. ◽

Aashish Sharma Konamme

Keyword(s):

Literature Review ◽

Microscopic Examination ◽

Lower Limb ◽

Skin Lesions ◽

The Other ◽

Middle Aged ◽

Aged Woman ◽

Middle Aged Woman ◽

Cutaneous Mycosis

Chromoblastomycosis is primarily a cutaneous mycosis caused by demetiaceous fungi. Microscopic examination with findings of muriform bodies are pathognomonic for the diagnosis of Chromoblastomycosis and if not specifically looked for, there is a chance of missing the diagnosis leading to improper treatment and complications. Here we report 2 cases, one of a middle aged woman, the other of an elderly man presenting with lower limb skin lesions histopathologically diagnosed as chromoblastomycosis.

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