Geographical Profiles of COVID-19 Outbreak in Tokyo: An Analysis of the Primary Care Clinic–Based Point-of-Care Antibody Testing

Introduction: The primary care clinic plays a major role in triage for coronavirus disease 2019 (COVID-19), where seroprevalence in the setting of primary care clinic remains less clear. As a point-of-care immunodiagnostic test for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the serosurvey represents an alternative to the polymerase chain reaction (PCR) test to measure the magnitude of COVID-19 outbreak in the communities lacking sufficient diagnostic capability for PCR testing. Methods: We assessed seropositivity for the SARS-CoV-2 IgG between April 21 and May 20, 2020, at 2 primary care clinics in Tokyo, Japan. Results: The overall positive percentage of SARS-CoV-2 IgG was 3.83% (95% confidence interval [CI]: 2.76-5.16) for the entire cohort (n = 1071). The 23 special wards of central Tokyo exhibited a significantly higher prevalence compared with the other areas of Tokyo after classification by residence ( P = .02, 4.68% [3.08-6.79] vs 1.83 [0.68-3.95] in central and suburban Tokyo, respectively). In central Tokyo, the southern area showed the highest seroprevalence compared with the other areas (7.92% [3.48-15.01]), corresponding to the cumulative number of confirmed COVID-19 patients by PCR test reported by the Tokyo Metropolitan Government. Conclusion: The seroprevalence surveyed in this study was too low for herd immunity, suggesting the need for robust disease control and prevention. A regional-level approach, rather than state- or prefectural-level, could be of importance in ascertaining detailed profiles of the COVID-19 outbreak.

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Regional Difference in Seroprevalence of SARS-CoV-2 in Tokyo: Results from the community point-of-care antibody testing

10.1101/2020.06.03.20121020 ◽

2020 ◽

Cited By ~ 4

Author(s):

Morihito Takita ◽

Tomoko Matsumura ◽

Kana Yamamoto ◽

Erika Yamashita ◽

Kazutaka Hosoda ◽

...

Keyword(s):

Regional Difference ◽

Point Of Care ◽

Herd Immunity ◽

Antibody Testing ◽

Igg Antibody ◽

Community Based ◽

Entire Cohort ◽

Control And Prevention ◽

Specific Igg ◽

Polymerase Chain

AbstractThe serosurvey is an alternative way to know the magnitude of the population infected by coronavirus disease 2019 (COVID-19) since the expansion of capacity of the polymerase chain reaction (PCR) to detect the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was delayed. We herein report seroprevalence of COVID-19 accessed in the two community clinics in Tokyo. The point-of-care immunodiagnostic test was implemented to detect the SARS-CoV-2 specific IgG antibody in the peripheral capillary blood. The overall positive percentage of SARS-CoV-2 IgG antibody is 3.83% (95% confidence interval: 2.76-5.16) for the entire cohort (n =1,071). The central Tokyo of 23 special wards exhibited a significantly higher prevalence compared to the other area of Tokyo (p =0.02, 4.68% [95%CI: 3.08-6.79] versus 1.83 [0.68-3.95] in central and suburban Tokyo, respectively). The seroprevalence of the cohort surveyed in this study is low for herd immunity, which suggests the need for robust disease control and prevention. A community-based approach, rather than state or prefectural levels, is of importance to figure out profiles of the SARS-COV-2 outbreak.

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A Late-Career Internist and Point-of-Care-Ultrasound in a Primary Care Clinic

Southern Medical Journal ◽

10.14423/smj.0000000000000829 ◽

2018 ◽

Vol 111 (7) ◽

pp. 418-420 ◽

Cited By ~ 2

Author(s):

Terry K. Rosborough ◽

David M. Tierney

Keyword(s):

Primary Care ◽

Point Of Care ◽

Primary Care Clinic ◽

Point Of Care Ultrasound ◽

Care Clinic

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Point-of-care testing improves diabetes management in a primary care clinic in South Africa

Primary Care Diabetes ◽

10.1016/j.pcd.2016.09.008 ◽

2017 ◽

Vol 11 (3) ◽

pp. 248-253 ◽

Cited By ~ 14

Author(s):

Lara A. Motta ◽

Mark D.S. Shephard ◽

Julie Brink ◽

Stefan Lawson ◽

Paul Rheeder

Keyword(s):

South Africa ◽

Primary Care ◽

Diabetes Management ◽

Point Of Care ◽

Primary Care Clinic ◽

Point Of Care Testing ◽

Care Clinic

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Time to Treatment and Patient Outcomes among TB Suspects Screened by a Single Point-of-Care Xpert MTB/RIF at a Primary Care Clinic in Johannesburg, South Africa

PLoS ONE ◽

10.1371/journal.pone.0065421 ◽

2013 ◽

Vol 8 (6) ◽

pp. e65421 ◽

Cited By ~ 53

Author(s):

Colleen F. Hanrahan ◽

Katerina Selibas ◽

Christopher B. Deery ◽

Heather Dansey ◽

Kate Clouse ◽

...

Keyword(s):

South Africa ◽

Primary Care ◽

Patient Outcomes ◽

Point Of Care ◽

Single Point ◽

Primary Care Clinic ◽

Care Clinic ◽

Time To Treatment

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Quantitative Longitudinal Antibody Monitoring numbered

10.22541/au.161833605.59590599/v1 ◽

2021 ◽

Author(s):

Nathalie Gil ◽

Jenny Heneriz ◽

Dennis Diaz ◽

Mike Tomas ◽

Gualberto Ruaño ◽

...

Keyword(s):

Primary Care ◽

Virus Disease ◽

Point Of Care ◽

Primary Care Clinic ◽

Case Series ◽

Care Clinic ◽

Clinical Symptomatology ◽

Corona Virus ◽

History Of ◽

Antibody Levels

A case series of 22 patients with confirmed SARS-CoV-2 infection and Corona Virus Disease 2019 (COVID-19) symptoms was followed in a primary care clinic. We provided quantitative and longitudinal profiling for SARS-CoV-2 IgM and IgG with a point of care device. Half the patients had a history of anosmia or ageusia. IgM and IgG responses were highly heterogeneous quantitatively and temporally. We determined that clinical symptomatology of chemosensory loss correlated with lesser but sustained titers of IgM and IgG whereas normal chemosensation correlated with transiently higher but rapidly declining antibody levels.

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Behavioural Psychotherapy in General Psychiatry

The British Journal of Psychiatry ◽

10.1192/bjp.150.5.593 ◽

1987 ◽

Vol 150 (5) ◽

pp. 593-597 ◽

Cited By ~ 7

Author(s):

I. Marks

Keyword(s):

Primary Care ◽

Learning Theory ◽

Primary Care Clinic ◽

The Other ◽

Detailed Knowledge ◽

Behavioural Treatment ◽

Care Clinic ◽

General Psychiatry ◽

The Subject

It is widely believed by psychiatrists that patients who require behavioural psychotherapy need to be referred for such treatment to a specialist in the subject. Two assumptions underlie this idea. One is that behavioural treatment requires a detailed knowledge of learning theory which is possessed by few psychiatrists. The other assumption is that behavioural methods are too time-consuming for a busy psychiatrist in a routine outpatient or primary care clinic.

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