Dermatofibrosarcoma Protuberans: A Review

Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue tumour of the dermis. Diagnosis may be very difficult from both a clinical and histopathological standpoint. DFSP has a peak incidence in patients between age 10 and 50 years old, occurs with relatively equal frequency in males and females and has a predilection to occur on the trunk or proximal limbs. The tumour has a very low metastatic potential but can be very locally aggressive, requiring wide surgical resection. The possible variants of DFSP may obscure diagnosis especially in the case of fibrohistiocytic lesions such as dermatofibroma, fibromatosis and malignant fibrous histiocytoma. Immunohistological testing, while not completely specific, shows promise in improving diagnostic accuracy. Wide local excision continues to be the mainstay of treatment, although Mohs’ micrographic surgery may ultimately provide superior cure rates.

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Dermatofibrosarcoma Protuberans Growing Around Plantar Aponeurosis: Excision by Mohs Micrographic Surgery

Dermatologic Surgery ◽

10.1046/j.1524-4725.2000.026010941.x ◽

2000 ◽

Vol 26 (10) ◽

pp. 941-945 ◽

Cited By ~ 13

Author(s):

Gregory J. Kricorian ◽

Carl F. Schanbacher ◽

Paul A. Kelly ◽

Richard G. Bennett

Keyword(s):

Dermatofibrosarcoma Protuberans ◽

Mohs Micrographic Surgery ◽

Micrographic Surgery ◽

Plantar Aponeurosis

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Dermatofibrosarcoma Protuberans in Childhood Treated with Slow Mohs Micrographic Surgery

Pediatric Dermatology ◽

10.1111/pde.12039 ◽

2013 ◽

Vol 30 (4) ◽

pp. 462-468 ◽

Cited By ~ 7

Author(s):

Marjam J. Barysch ◽

Lisa Weibel ◽

Kathrin Neuhaus ◽

Ulrike Subotic ◽

Leo Schärer ◽

...

Keyword(s):

Dermatofibrosarcoma Protuberans ◽

Mohs Micrographic Surgery ◽

Micrographic Surgery

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Mohs micrographic surgery: a study of 83 cases

Anais Brasileiros de Dermatologia ◽

10.1590/s0365-05962012000200006 ◽

2012 ◽

Vol 87 (2) ◽

pp. 228-234 ◽

Cited By ~ 7

Author(s):

Flavianne Sobral Cardoso Chagas ◽

Bruno de Santana Silva

Keyword(s):

Cell Carcinoma ◽

Medical Records ◽

Cross Sectional Study ◽

Mohs Micrographic Surgery ◽

Micrographic Surgery ◽

Cross Sectional ◽

The Mean ◽

Nasal Region ◽

Cure Rates ◽

Observation Period

BACKGROUND: Mohs micrographic surgery can achieve high cure rates in the treatment of skin cancer and remove a minimum of healthy tissue. OBJECTIVES: To characterize patients undergoing Mohs micrographic surgery and study issues related to the number of surgical stages. METHODS: A descriptive, retrospective, cross-sectional study was conducted in a micrographic surgery reference center for the period of 2004 to 2010. Data was collected from medical records of 79 patients (83 surgeries). RESULTS: We studied 43 women and 36 men. The mean age was 57.5 ± 14,6 years. Skin types II and III were the most frequent, accounting for 41% and 36.1%, respectively. The most frequent tumor was the basal cell carcinoma (89.1%), and the solid subtype was the most common (44.6%), followed by sclerodermiform histological subtype (32%).The most frequent location was the nasal region (44.6%). The large majority of the operated tumors were recurrent lesions (72.7%). Half of the tumors measured 2 cm or more. In 68.7% of the cases two or more surgical stages were necessary for the removal of the tumors. The observation period was 2 or more years in 75% of the tumors. There was 01 post-Mohs recurrence and 02 patients had metastases during the observation period (both with squamous cell carcinoma). CONCLUSION: The findings coincide with those of the literature, recurrent tumors and tumors larger than 2cm needed more surgical stages for their removal, although there was no statistic difference (p=0,12 and 0,44 respectively).

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