Osteochondral Defects of the Knee treated with Mosaicplasty. Results at Eight Years of Follow-Up

Objectives: There are several surgical options described for osteochondral defects of the knee depending on the size, location and condition of subchondral bone. The main indication for a mosaicplasty procedure is a less than 4 cm2 femoral condyle lesion. The purpose of this study was to analyze a series of patients treated with mosaicplasty with average eight years of follow-up. Methods: We retrospectively evaluated sixty-two patients with osteochondral defects of the knee who underwent a mosaicplasty between 2001 and 2014 with a minimum follow-up of 2 years. Patients were evaluated using the Lysholm score, International Knee Documentation Committee Score (IKDC) and Kellgren-Lawrence radiographic scale. Results: The mean Lysholm score was 80.1 and IKDC was 66.7. Forty-two patients had isolated mosaicplasty and 20 patients presented an associated surgical procedure (osteotomy, ACL reconstruction, meniscectomy). There were no significant differences between the Lysholm and IKDC scores in these two groups. Conclusion: We consider that mosaicplasty is a satisfactory procedure with good functional results in patients with focal articular cartilage lesions of the knee.

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Locking Plate alone or in Combination with Cannulated Screws for Hoffa Fractures: A retrospective cohort study

10.21203/rs.3.rs-203399/v2 ◽

2021 ◽

Author(s):

Zhen Li ◽

Zhenyue Chen ◽

Xiaotan Wang ◽

Jingyin Li ◽

Lizhong Jing ◽

...

Keyword(s):

Cohort Study ◽

Knee Joint ◽

Locking Plate ◽

Functional Results ◽

International Knee Documentation Committee ◽

Cannulated Screws ◽

Range Of Movement ◽

The Mean ◽

Active Rehabilitation

Abstract Purpose Locking plate or screws have been used for Hoffa fractures; however, evidence to support the effectiveness of the procedure remains scarce. The present study aimed to determine the efficacy of distal femur condyle locking plate(DFCLP)alone or in combination with cannulated screws for Hoffa fractures. Methods In this cohort study, 13 patients with isolated Hoffa fractures were enrolled during the study period (May 2014 to February 2019) and retrospectively analyzed. Patients underwent open reduction and internal fixation by DFCLP alone or in combination with cannulated screws followed by early active rehabilitation postoperatively. The primary outcome was evaluated with Knee Society Score (KSS), the range of movement (ROM), International Knee Documentation Committee (IKDC) scoring system and the stability of the fixation site of the patients during the 24-month follow-up period. Results A total of 13 patients completed the 24-month follow-up assessment and achieve bone re-union at Hoffa fracture sites. The average follow-up period was 24.5months (ranging from 24 to 28 months), and the average time to healing was 3.5 months (ranging from 3 to 4 months). The mean ROM was determined as 119°, the mean KSS was 87.9, and the mean IKDC score was 84.2. It is worth mentioning that 2 patients suffered from knee joint stiffness and osteoarthritis during the 24 months follow-up. Eleven patients (84.6%) achieved satisfactory knee joint function through early postsurgical rehabilitation. Conclusion In patients with Hoffa fractures, treatment with DFCLP alone or in combination with cannulated screws followed by early active rehabilitation resulted in great stability and satisfactory functional results after 24 months.

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Management of Patellar Chondral Defects with Autologous Matrix Induced Chondrogenesis (AMIC) Compared to Microfractures: A Four Years Follow-Up Clinical Trial

Life ◽

10.3390/life11020141 ◽

2021 ◽

Vol 11 (2) ◽

pp. 141

Author(s):

Filippo Migliorini ◽

Jörg Eschweiler ◽

Nicola Maffulli ◽

Arne Driessen ◽

Björn Rath ◽

...

Keyword(s):

International Knee Documentation Committee ◽

Defect Size ◽

Lysholm Score ◽

Facet Joints ◽

Chondral Defects ◽

Mean Size ◽

The Mean ◽

Rate Of Failure ◽

Tegner Activity Scale

Introduction: Evidence on the management of chondral defects of the patella arises from studies in which the patellofemoral joint was treated together with the femorotibial joint and primary and revision settings. Furthermore, the superiority of Autologous Matrix Induced Chondrogenesis (AMIC) over microfractures (MFx) for patellar chondral defects is uncertain. Therefore, the present study compared primary isolated AMIC versus MFx for focal unipolar chondral defects of the patellar facet joints at midterm follow-up. Methods: Patients undergoing AMIC or isolated MFx surgery for borderline-sized focal unipolar chondral defects of the patellar facet joints were followed at our institution. All surgeries were performed in the same fashion by experienced surgeons. A parapatellar arthrotomy was adopted in all surgeries. The outcomes of interest were: Visual Analogic Scale (VAS), Tegner Activity Scale, International Knee Documentation Committee (IKDC), and the Lysholm scores. The Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) was assessed by a blinded radiologist, who had not been involved in the clinical management of the patients. Results: 38 patients were enrolled in the present study: 27 underwent AMIC, and 11 MFx. The mean follow-up was 45.1 months. The mean age of the patients at baseline was 34.5 years. The mean size of the defect was 2.6 cm2. The MFx cohort experienced a shorter length of the hospitalization (P = 0.008). There was no difference in terms of follow-up and previous symptoms duration, mean age, sex, side, defect size, and BMI. At last follow-up, the AMIC cohort reported greater IKDC (P = 0.01), Lysholm (P = 0.009), and Tegner (P = 0.02), along with a low rate of failure (P = 0.02). VAS was lower in the AMIC group (P = 0.002). No difference was found in the MOCART score (P = 0.09), rates of revision (P = 0.06), and arthroplasty (P = 0.2). Conclusion: The AMIC procedure achieves greater IKDC and Lysholm score, and a significant reduction of the VAS score in the management of patellar chondral defects. The Tegner scale demonstrated greater activity after AMIC procedure. Finally, the AMIC group evidenced a lower rate of failure. Similarity was found on MOCART score, rates of revision, and arthroplasty between the two procedures.

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Locking Plate Alone or in Combination With Cannulated Screws for Hoffa Fractures: a Retrospective Cohort Study

10.21203/rs.3.rs-203399/v1 ◽

2021 ◽

Author(s):

Zhen Li ◽

Zhenyue Chen ◽

Xiaotan Wang ◽

Jingyin Li ◽

Lizhong Jing ◽

...

Keyword(s):

Cohort Study ◽

Knee Joint ◽

Locking Plate ◽

Functional Results ◽

International Knee Documentation Committee ◽

Cannulated Screws ◽

Range Of Movement ◽

The Mean ◽

Active Rehabilitation

Abstract Purpose: Locking plate or screws have been used for Hoffa fractures; however, evidence to support the effectiveness of the procedure remains scarce. The present study aimed to determine the efficacy of distal femur condyle locking plate（DFCLP）alone or in combination with cannulated screws for Hoffa fractures.Methods: In this cohort study, 13 patients with isolated Hoffa fractures were enrolled during the study period (May 2014 to February 2019) and retrospectively analyzed. Patients underwent open reduction and internal fixation by DFCLP alone or in combination with cannulated screws followed by early active rehabilitation postoperatively. The primary outcome was evaluated with Knee Society Score (KSS), the range of movement (ROM), International Knee Documentation Committee (IKDC) scoring system and the stability of the fixation site of the patients during the 24-month follow-up period.Results: A total of 13 patients completed the 24-month follow-up assessment and achieve bone re-union at Hoffa fracture sites. The average follow-up period was 24.5months (ranging from 24 to 28 months), and the average time to healing was 3.5 months (ranging from 3 to 4 months). The mean ROM was determined as 119°, the mean KSS was 87.9, and the mean IKDC score was 84.2. It is worth mentioning that 2 patients suffered from knee joint stiffness and osteoarthritis during the 24 months follow-up. Eleven patients (84.6%) achieved satisfactory knee joint function through early postsurgical rehabilitation.Conclusion: In patients with Hoffa fractures, treatment with DFCLP alone or in combination with cannulated screws followed by early active rehabilitation resulted in great stability and satisfactory functional results after 24 months.

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Systematic Review and Meta-Analysis of the Clinical Evidence on the Use of Autologous Matrix-Induced Chondrogenesis in the Knee

Cartilage ◽

10.1177/1947603519870846 ◽

2019 ◽

pp. 194760351987084 ◽

Cited By ~ 5

Author(s):

Matthias R. Steinwachs ◽

Justus Gille ◽

Martin Volz ◽

Sven Anders ◽

Roland Jakob ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Clinical Status ◽

Real Life ◽

International Knee Documentation Committee ◽

Lysholm Score ◽

Osteochondral Lesions ◽

Ikdc Score ◽

The Mean

Objective A systematic review and meta-analysis of Autologous Matrix-Induced Chondrogenesis (AMIC®) outcomes for grade III/IV chondral and osteochondral lesions of the knee treated with Chondro-Gide®. Design Studies with a minimum follow-up of 1 year providing clinical results of AMIC repair in the knee were included based on PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). Methodological quality was assessed by the modified Coleman Methodology Score (mCMS). The meta-analysis was comparing pain VAS (Visual Analog Scale), Lysholm score, and IKDC score (International Knee Documentation Committee) between baseline and follow-up after 1 or 2 years and after >3 years. Results Twelve studies (375 patients) were included. The mCMS demonstrated a suboptimal study design (ranking between 52 and 80). The mean age was 36.2 years (14-70 years). The mean defect size was 4.24 cm2 (0.8-22 cm2). The results from the random effects model indicated a clinically significant ( P < 0.05) improvement of pain VAS from baseline to follow-up at year 1 to 2 of −4.02(confidence interval −4.37; −3.67), still significant after 3 years. Lysholm score at year 1 or 2 improved significantly and remained highly significant after 3 years. IKDC score showed highly significant improvement of 32.61 between 1 and 2 years versus baseline values maintained after 3 years. Conclusions The AMIC procedure significantly improved the clinical status and functional scoring versus preoperative values. Evidence was obtained in a non-selected patient population, corresponding to real-life treatment of knee chondral and osteochondral defects. The evidence is sufficient to recommend AMIC in this indication.

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Surgical Treatment for Avulsion Fractures of the Anterolateral Ligament Associated with Periarticular Fractures of the Knee

10.21203/rs.3.rs-26495/v1 ◽

2020 ◽

Author(s):

Xuelei Wei ◽

Zengliang Wang ◽

Yandong Lu ◽

Jie Sun ◽

John Riehl

Keyword(s):

Avulsion Fracture ◽

Pivot Shift ◽

International Knee Documentation Committee ◽

Lysholm Score ◽

Pivot Shift Test ◽

X Rays ◽

Avulsion Fractures ◽

Ikdc Score ◽

The Mean

Abstract Background: To confirm the existence of the ALL and evaluate the clinical outcomes of surgical management for avulsion fractures involving its insertion when associated with periarticular knee fractures.Methods: Twenty-three patients (16 males and 7 females) with avulsion fractures of the ALL associated with periarticular knee fractures were fixed with a spider plate, cannulated screw, or suture anchor. Eight patients were diagnosed with distal femoral fracture, 10 with tibial plateau fracture, and 5 with tibial eminence avulsion fracture. All patients underwent X-rays at follow-up. Clinical and functional outcomes were assessed with the pivot-shift test, objective and subjective International Knee Documentation Committee (IKDC) score, Lysholm score, and Tegner activity scale.Results: The ALL was found and identified as a distinct ligamentous structure in all patients. Pre-Segond repair, patients had significantly more instability as determined by pivot-shift test than seen postoperatively (P < .0001). At final follow-up, the mean subjective IKDC score was 83.2±10.3. Fourteen patients were graded A, 6 were graded B, and 3 was graded C on the IKDC objective score. The mean Lysholm score was 85.4 ± 12.2. The mean Tegner score was 7.5 ± 1.2.Conclusion: This study confirmed that the ALL is a distinct structure in the anterolateral portion of the knee. The fixation for the avulsion fracture of the ALL associated with periarticular knee fractures can be an effective procedure without specific complications. Longer term and comparative follow-up studies are necessary to confirm the effects.

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Midterm Outcomes of Autologous Osteochondral Graft Transplantation Only in the Femoral Condyle without Treating the Tibial Plateau with Subchondral Bone Exposed

Cartilage ◽

10.1177/1947603520967066 ◽

2020 ◽

pp. 194760352096706

Author(s):

Yasuaki Nakagawa ◽

Shogo Mukai ◽

Takahiro Maeda ◽

Shota Akamatsu ◽

Kentaro Satomi ◽

...

Keyword(s):

Clinical Outcomes ◽

Subchondral Bone ◽

Tibial Plateau ◽

Femoral Condyle ◽

International Knee Documentation Committee ◽

Japanese Orthopedic Association ◽

Clinical Scores ◽

The Mean ◽

Better Than

Objective This study aimed to examine the midterm clinical outcomes of autologous osteochondral grafts (AOG) that were performed in the femoral condyle without treating the tibial plateau with subchondral bone exposed, and to compare these outcomes with those of AOG used in patients with osteoarthritis (lateral type or medial type) or osteonecrosis. Design The study included 6 men and 16 women and 11 right knees and 11 left knees. The mean operative age was 56.0 years (range, 21-76 years), and the mean follow-up period was 98.4 months (range, 60-164 months). Six patients had lateral type osteoarthritis (OAL), 7 had medial type osteoarthritis (OAM), and 9 had osteonecrosis (ON). The patients’ knee symptoms as their clinical outcome were evaluated using the knee scoring system of the Japanese Orthopedic Association (JOA), and the International Knee Documentation Committee (IKDC) subjective score. Results The postoperative clinical outcomes of the OAL and ON group were significantly better than their preoperative clinical scores and remained the same until the final follow-up. However, the clinical outcomes of OAM improved 2 years after AOG, but eventually decreased thereafter. The number of worse cases in the OAM group was significantly larger than those in the OAL and ON groups. Conclusion In these procedures, the postoperative clinical outcomes of the OAL and ON groups were significantly better than their preoperative clinical scores and were maintained for about 8 years. However, the clinical outcomes of OAM improved until 2 years after AOG, but eventually decreased thereafter.

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Autologous Matrix-Induced Chondrogenesis for Treatment of Focal Cartilage Defects in the Knee: A Follow-up Study

Orthopaedic Journal of Sports Medicine ◽

10.1177/2325967120981872 ◽

2021 ◽

Vol 9 (2) ◽

pp. 232596712098187

Author(s):

Justus Gille ◽

Ellen Reiss ◽

Moritz Freitag ◽

Jan Schagemann ◽

Matthias Steinwachs ◽

...

Keyword(s):

Repeated Measures ◽

Demographic Data ◽

Case Series ◽

Defect Size ◽

Lysholm Score ◽

Outcome Analysis ◽

Cartilage Defects ◽

Chondral Defects ◽

The Mean

Background: Autologous matrix-induced chondrogenesis (AMIC) is a well-established treatment for full-thickness cartilage defects. Purpose: To evaluate the long-term clinical outcomes of AMIC for the treatment of chondral lesions of the knee. Study Design: Case series; Level of evidence, 4. Methods: A multisite prospective registry recorded demographic data and outcomes for patients who underwent repair of chondral defects. In total, 131 patients were included in the study. Lysholm, Knee injury and Osteoarthritis Outcome Score (KOOS), and visual analog scale (VAS) score for pain were used for outcome analysis. Across all patients, the mean ± SD age of patients was 36.6 ± 11.7 years. The mean body weight was 80.0 ± 16.8 kg, mean height was 176.3 ± 7.9 cm, and mean defect size was 3.3 ± 1.8 cm2. Defects were classified as Outerbridge grade III or IV. A repeated-measures analysis of variance was used to compare outcomes across all time points. Results: The median follow-up time for the patients in this cohort was 4.56 ± 2.92 years. Significant improvement ( P < .001) in all scores was observed at 1 to 2 years after AMIC, and improved values were noted up to 7 years postoperatively. Among all patients, the mean preoperative Lysholm score was 46.9 ± 19.6. At the 1-year follow-up, a significantly higher mean Lysholm score was noted, with maintenance of the favorable outcomes at 7-year follow-up. The KOOS also showed a significant improvement of postoperative values compared with preoperative data. The mean VAS had significantly decreased during the 7-year follow-up. Age, sex, and defect size did not have a significant effect on the outcomes. Conclusion: AMIC is an effective method of treating chondral defects of the knee and leads to reliably favorable results up to 7 years postoperatively.

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Internal Fixation of Lateral Trochlear Groove Osteochondritis Dissecans With Simultaneous Lateral Retinacular Lengthening in Adolescent Athletes

The American Journal of Sports Medicine ◽

10.1177/03635465211047851 ◽

2021 ◽

pp. 036354652110478

Author(s):

Dhong Won Lee ◽

Joon Kyu Lee ◽

Young Chang Cho ◽

Sang Jin Yang ◽

Seung Ik Cho ◽

...

Keyword(s):

Internal Fixation ◽

Vertical Jump ◽

Lysholm Score ◽

Trochlear Groove ◽

Adolescent Athletes ◽

Isokinetic Muscle Strength ◽

Subjective Score ◽

The Mean ◽

Tegner Activity Scale

Background: The goals of operative treatment for the adolescent athlete with unstable osteochondritis dissecans (OCD) lesion are rigid fixation and prevention of recurrence. Purpose: To evaluate clinical and radiological outcomes of internal fixation of lateral trochlear groove OCD with simultaneous lateral retinacular lengthening. Study Design: Case series; Level of evidence, 4. Methods: Adolescent athletes who had undergone internal fixation and simultaneous lateral retinacular lengthening for an unstable OCD lesion of the lateral trochlear groove were retrospectively reviewed. Subjective assessments included the Lysholm score, International Knee Documentation Committee (IKDC) subjective score, Tegner activity scale, and an athletic questionnaire. Functional tests included isokinetic muscle strength, single-leg hop for distance, single-leg vertical jump, and Y-balance. Pre- and postoperative radiographs and magnetic resonance images were reviewed. Results: The mean ± SD age of the 17 patients included in this study was 15.9 ± 0.9 years; last clinical follow-up duration was 37.7 ± 8.1 months. At the last follow-up, the Lysholm score improved from 68.7 ± 15.3 to 93.4 ± 12.4 and the IKDC subjective score from 60.2 ± 14.7 to 88.7 ± 12.7 ( P < .001). The mean Tegner activity scale score was 9.4 ± 0.5 before injury and 8.9 ± 1.2 at the last follow-up ( P = .059). The limb symmetry indices of isokinetic muscle strength, single-leg hop for distance, single-leg vertical jump, and Y-balance improved at the last follow-up; the mean limb symmetry index was ≥85% in each functional test. Regarding the athletic questionnaire, 16 (94.1%) patients were satisfied with the surgery. At the last follow-up, 2 patients had higher ability after returning to sports, 11 had the same ability, and 3 had lower ability than the preinjury level. Postoperative magnetic resonance imaging at 12-month follow-up showed that the OCD lesion appeared healed in 7 (41.2%) patients and partially healed in 9 (52.9%). Conclusion: Internal fixation of lateral trochlear groove OCD with simultaneous lateral retinacular lengthening in adolescent athletes achieved satisfactory clinical and radiological outcomes. Therefore, this combined surgical technique could be considered an effective treatment for lateral trochlear groove OCD, with a high rate of return to sport.

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Role of leukocyte free platelet rich plasma in planter fasciitis: a prospective study

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20175468 ◽

2017 ◽

Vol 5 (12) ◽

pp. 5432

Author(s):

Chandre Shekhar ◽

Alamgir Jhan ◽

Ganesh Singh ◽

Pankaj Singh ◽

Shailendre S. Bhandhari

Keyword(s):

Placebo Group ◽

Functional Outcome ◽

Platelet Rich Plasma ◽

Functional Results ◽

Visual Analogue Scale Pain ◽

Functional Score ◽

Outcome Scores ◽

The Mean ◽

Post Graduate Institute

Background: Planter fasciitis, is by definition, inflammation of planter fascia. Most of the cases are well treated conservatively and a few responds to surgery only. Objectives of present study were evaluating the efficacy of a single injection of leukocyte free platelet rich plasma in plantar fasciitis and to derive a correlation between the clinical and radiological outcome.Methods: The present study consisted of 120 patients of bilateral (PF), (240 feet). These patients were divided into two groups PRP group of 60 patients and Placebo group of 60 patients. The study was conducted on patients attending Orthopaedics outpatient department Post Graduate Institute of Medial Education and Research (PGIMER) from July 2011 to June 2012. A primary efficacy criterion was changes from baseline in pain using (VAS). Functional results, level of satisfaction and outcome were measured by – AOFAS Foot Scale. Correlation of clinical with radiological outcome were performed.Results: There was a significant decrease in the visual analogue scale (pain score) in the PRP. Group while in placebo group it was increased significantly at the end of 6 month. Functional outcome scores were improved significantly from their baseline values in PRP group while in placebo group the mean functional score were deteriorated at 6 months follow up. There was no improvement seen in functional status with normal saline injection. In PRP group the mean heal pad thickness was reduced significantly at 6 months follow up while in placebo group was not changed significantly at 6 months follow up. Correlation between radiological parameters and VAS was found to be positive while it was found negative with other functional outcome scores like AOFAS.Conclusions: Platelet-rich plasma (PRP), which is a natural concentrate of autologous growth factors,plays a role in the regeneration process in treatment of (PF).

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Preliminary Results in Anatomic All-inside Anterior Cruciate Ligament Reconstruction

Journal of Interdisciplinary Medicine ◽

10.1515/jim-2016-0050 ◽

2016 ◽

Vol 1 (s2) ◽

pp. 23-26

Author(s):

Octav Russu ◽

Tiberiu Bățagă ◽

Andrei-Marian Feier ◽

Radu Prejbeanu ◽

Radu Fleaca ◽

...

Keyword(s):

Anterior Cruciate Ligament ◽

Acl Reconstruction ◽

Cruciate Ligament ◽

Knee Laxity ◽

Clinical Results ◽

Lysholm Score ◽

X Rays ◽

The Mean ◽

Anterior Cruciate

Abstract Introduction: Anterior cruciate ligament (ACL) rupture is one of the most common lesions in knee traumatology; therefore the number of ACL reconstructions is increasing worldwide. Usually, an anteromedial (AM) accessory portal is required in anatomical positioning of the femoral tunnel, which is not absolutely necessary in this technique. Aim: Assessment of all-inside ACL reconstruction preliminary clinical results with adjustable loops and buttons on both femoral and tibial surfaces. Method: Our prospective study included 28 subjects (19 male, 9 female) with chronic ACL ruptures. The mean age of the study population was 27.72 ± 8.23 years. In all cases ACL reconstruction was carried out with the use of quadrupled semitendinosus auto-grafts with adjustable loops and buttons on the femoral and tibial surfaces and anatomic placement of both tunnels, using an outside-in technique, with flipcutters (Arthrex®). Clinical and radiological evaluations were carried out before surgery and at 3 and 6 months postoperatively, with the Lysholm scoring system, the Tegner activity scale and anterior-posterior and latero-lateral X-rays. Anterior knee laxity was measured in 25° of flexion using a portable arthrometer (RolimeterTM, Aircast®) and maximum manual force. Results: During the final follow-up, the Lysholm score was good and excellent in 27 cases, with a mean Lysholm score of 95.55 ± 4.63; all results were classified as good. The mean preoperative Tegner activity score was 3.46 ± 1.71 (range: 1-7), and the post-operative mean score was 5.75 ± 2.24 (range: 2-10). We found no graft ruptures. Preoperative knee laxity measurements showed a mean displacement of 11.5 ± 3.1 mm and side-to-side differences of 5.6 ± 3.5 mm, while the postoperative measurements at the last follow-up were 6.3 ± 1.54 mm and 2.65 ± 1.86 mm, respectively. Conclusion: Short-term clinical outcomes of all-inside ACL restoration with anatomic placement femoral and tibial tunnels seem to recommend this surgical option, with good subjective and objective results. Additional research will have to prove the long-term success.

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