Lesions of retrosplenial cortex spare immediate-early gene activity in related limbic regions in the rat

The retrosplenial cortex forms part of a network of cortical and subcortical structures that have particular importance for spatial learning and navigation in rodents. This study examined how retrosplenial lesions affect activity in this network by visualising the expression of the immediate-early genes c- fos and zif268 after exposure to a novel location. Groups of rats with extensive cytotoxic lesions (areas 29 and 30) and rats with lesions largely confined to area 30 (dysgranular cortex) were compared with their respective control animals for levels of c- fos expression measured by immunohistochemistry. These cortical lesions had very limited effects on distal c- fos activity. Evidence of a restricted reduction in c-fos activity was seen in the septal dentate gyrus (superior blade) but not in other hippocampal and parahippocampal subareas, nor in the anterior cingulate and prelimbic cortices. Related studies examined zif268 activity in those cases with combined area 29 and 30 lesions. The only clear evidence for reduced zif268 activity following retrosplenial cell loss came from the septal CA3 area. The confined impact of retrosplenial tissue loss is notable as, by the same immediate-early gene measures, retrosplenial cortex is itself highly sensitive to damage in related limbic areas, showing a marked c- fos and zif268 hypoactivity across all of its subareas. This asymmetry in covert pathology may help to explain the apparent disparity between the severity of learning deficits after retrosplenial cortex lesions and after lesions in either the hippocampus or the anterior thalamic nuclei.

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Neural systems underlying episodic memory: insights from animal research

Philosophical Transactions of the Royal Society B Biological Sciences ◽

10.1098/rstb.2001.0946 ◽

2001 ◽

Vol 356 (1413) ◽

pp. 1467-1482 ◽

Cited By ~ 98

Author(s):

John P. Aggleton ◽

John M. Pearce

Keyword(s):

Episodic Memory ◽

Spatial Memory ◽

Immediate Early Gene ◽

Retrosplenial Cortex ◽

Early Gene ◽

Immediate Early ◽

Neural Systems ◽

Thalamic Nuclei ◽

Component Structure ◽

New Findings

Two strategies used to uncover neural systems for episodic–like memory in animals are discussed: (i) an attribute of episodic memory ( what ? when ? where ?) is examined in order to reveal the neuronal interactions supporting that component of memory; and (ii) the connections of a structure thought to be central to episodic memory in humans are studied at a level of detail not feasible in humans. By focusing on spatial memory ( where ?) and the hippocampus, it has proved possible to bring the strategies together. A review of lesion, disconnection and immediate early–gene studies in animals reveals the importance of interactions between the hippocampus and specific nuclei in the diencephalon (most notably the anterior thalamic nuclei) for spatial memory. Other parts of this extended hippocampal system include the mammillary bodies and the posterior cingulate (retrosplenial) cortex. Furthermore, by combining lesion and immediate early–gene studies it is possible to show how the loss of one component structure or tract can influence the remaining regions in this group of structures. The validity of this convergent approach is supported by new findings showing that the same set of regions is implicated in anterograde amnesia in humans.

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Hippocampal lesions halve immediate-early gene protein counts in retrosplenial cortex: distal dysfunctions in a spatial memory system

European Journal of Neuroscience ◽

10.1111/j.1460-9568.2007.05753.x ◽

2007 ◽

Vol 26 (5) ◽

pp. 1254-1266 ◽

Cited By ~ 55

Author(s):

Mathieu M. Albasser ◽

Guillaume L. Poirier ◽

E. Clea Warburton ◽

John P. Aggleton

Keyword(s):

Spatial Memory ◽

Immediate Early Gene ◽

Memory System ◽

Retrosplenial Cortex ◽

Early Gene ◽

Immediate Early ◽

Hippocampal Lesions

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Anterior thalamic lesions stop immediate early gene activation in selective laminae of the retrosplenial cortex: evidence of covert pathology in rats?

European Journal of Neuroscience ◽

10.1111/j.0953-816x.2004.03421.x ◽

2004 ◽

Vol 19 (12) ◽

pp. 3291-3304 ◽

Cited By ~ 48

Author(s):

Trisha A. Jenkins ◽

Seralynne D. Vann ◽

Eman Amin ◽

John P. Aggleton

Keyword(s):

Gene Activation ◽

Immediate Early Gene ◽

Retrosplenial Cortex ◽

Early Gene ◽

Immediate Early ◽

Thalamic Lesions

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Post-surgical interval and lesion location within the limbic thalamus determine extent of retrosplenial cortex immediate-early gene hypoactivity

Neuroscience ◽

10.1016/j.neuroscience.2009.02.021 ◽

2009 ◽

Vol 160 (2) ◽

pp. 452-469 ◽

Cited By ~ 26

Author(s):

G.L. Poirier ◽

J.P. Aggleton

Keyword(s):

Immediate Early Gene ◽

Retrosplenial Cortex ◽

Early Gene ◽

Immediate Early ◽

Lesion Location ◽

Limbic Thalamus

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Afferent Projections to Area Prostriata of the Mouse

Frontiers in Neuroanatomy ◽

10.3389/fnana.2020.605021 ◽

2020 ◽

Vol 14 ◽

Author(s):

Jin-Meng Hu ◽

Chang-Hui Chen ◽

Sheng-Qiang Chen ◽

Song-Lin Ding

Keyword(s):

Visual Information ◽

Retrosplenial Cortex ◽

Anterior Cingulate ◽

Thalamic Nuclei ◽

Unique Region ◽

Fast Detection ◽

Afferent Projections ◽

Cells Of Origin ◽

Anterior Thalamic Nuclei ◽

Auditory Cortices

Area prostriata plays important roles in fast detection and analysis of peripheral visual information. It remains unclear whether the prostriata directly receives and integrates information from other modalities. To gain insight into this issue, we investigated brain-wide afferent projections to mouse prostriata. We find convergent projections to layer 1 of the prostriata from primary and association visual and auditory cortices; retrosplenial, lateral entorhinal, and anterior cingulate cortices; subiculum; presubiculum; and anterior thalamic nuclei. Innervation of layers 2–3 of the prostriata mainly originates from the presubiculum (including postsubiculum) and anterior midline thalamic region. Layer 5 of the prostriata mainly receives its inputs from medial entorhinal, granular retrosplenial, and medial orbitofrontal cortices and anteromedial thalamic nucleus while layer 6 gets its major inputs from ectorhinal, postrhinal, and agranular retrosplenial cortices. The claustrum, locus coeruleus, and basal forebrain provide relatively diffuse innervation to the prostriata. Moreover, Cre-dependent tracing in cortical areas reveals that the cells of origin of the prostriata inputs are located in layers 2–4 and 5 of the neocortical areas, layers 2 and 5 of the medial entorhinal cortex, and layer 5 of the retrosplenial cortex. These results indicate that the prostriata is a unique region where primary and association visual and auditory inputs directly integrate with many limbic inputs.

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