Radiation nephropathy: Dose, management, and population risk

2021 ◽  
pp. 239936932110640
Author(s):  
Eric P Cohen ◽  
Tihana Premuzic ◽  
Alexander P Cohen
Keyword(s):  
Oxidative Dna Damage ◽  
Clinical Medicine ◽  
Renin Angiotensin System ◽  
Conclusive Evidence ◽  
External Beam Irradiation ◽  
Angiotensin System ◽  
Dose Management ◽  
Stage Renal Disease ◽  
End Stage ◽  
Radiation Nephropathy

Radiation nephropathy is renal injury caused by a sufficient dose of irradiation. It can result from external beam irradiation or internal irradiation as might occur from therapeutic radioisotopes. Its usual clinical presentation is as chronic kidney disease occurring some months after irradiation, and it can evolve to end-stage-renal-disease. While the immediate cellular injury from irradiation depends on radiolysis of water and oxidative DNA damage, there is no conclusive evidence for chronic persistent oxidative stress or inflammation as the cause of the multi-tissue scarring that ensues. Antagonists of the renin-angiotensin system are effective treatments for experimental radiation nephropathy but their preferential value in human clinical medicine is unproven.

scholarly journals Circulating Renin Angiotensin System in Childhood Chronic Renal Failure: Marked Increase of Angiotensin-(1–7) in End-Stage Renal Disease

2006 ◽  
Vol 60 (6) ◽  
pp. 734-739 ◽  
Author(s):  
Ana C Simões E Silva ◽  
José Silvério S Diniz ◽  
Regina M Pereira ◽  
Sérgio V Brant Pinheiro ◽  
Robson Augusto S Santos
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Genetic polymorphisms of the renin-angiotensin system in end-stage renal disease

2005 ◽  
Vol 21 (4) ◽  
pp. 979-983 ◽  
Author(s):  
Monika Buraczynska ◽  
Piotr Ksiazek ◽  
Andrzej Drop ◽  
Wojciech Zaluska ◽  
Danuta Spasiewicz ◽  
...  
Keyword(s):  
Renal Disease ◽  
Genetic Polymorphisms ◽  
End Stage Renal Disease ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Stage Renal Disease ◽  
End Stage

The effect of renin–angiotensin system blockade on the incidence of end-stage renal disease in IgA nephropathy

2015 ◽  
Vol 20 (5) ◽  
pp. 689-698 ◽  
Author(s):  
Shigeru Tanaka ◽  
Toshiharu Ninomiya ◽  
Ritsuko Katafuchi ◽  
Kosuke Masutani ◽  
Masaharu Nagata ◽  
...  
Keyword(s):  
Renal Disease ◽  
Iga Nephropathy ◽  
End Stage Renal Disease ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Oncogenic mechanisms in renal insufficiency

2020 ◽  
Author(s):  
Simona Ruxandra Volovat ◽  
Constantin Volovat ◽  
Ingrith Miron ◽  
Mehmet Kanbay ◽  
David Goldsmith ◽  
...  
Keyword(s):  
Renal Insufficiency ◽  
Survival Rates ◽  
Renin Angiotensin System ◽  
Immune Dysfunction ◽  
Angiotensin System ◽  
Stage Renal Disease ◽  
End Stage ◽  
Medical Advances ◽  
The Relationship ◽  
Stimulation Of

Abstract The prevalence of both cancer and end-stage renal disease is increasing. In addition, medical advances have meant increased survival rates for both diseases. Many chemotherapeutics are renally excreted, and conversely, renal insufficiency promotes a pro-neoplastic state, including genitourinary and other cancers. Dialysis prolongs life while increasing cancer risk. Proposed oncogenic mechanisms include immune dysfunction, chronic inflammation, changes in gut microbiota and stimulation of the renin–angiotensin system. This review summarizes current concepts in the relationship between cancer and renal insufficiency.

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