Familial periodicity in a multigenerational family of cluster headache: A case report

I describe an unusual phenotypic phenomenon in two members of a multigenerational family of cluster headache (CH) with anticipation features. The index case, a 44-year-old woman, and her sister, a 40-year-old woman, have a CH phenotype with atypical features as the burning of the nose. Besides identically circadian and circannual features, they present distinct chronobiological features with the onset of the episodic pain attack every third day between them. I propose to entitle this clinical feature “familial periodicity” because of the remarkable phenotypic correlation and probably a similar genotype in the two sisters. Pathophysiologically, this phenomenon may be the result of the dysfunction of the suprachiasmatic nucleus of the hypothalamus on a genetic basis. This is the first case of familial periodicity, which allows extending the clinical spectrum of CH.

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Hemicrania Continua with Contralateral Episodic Cluster Headache: A Case Report

Cephalalgia ◽

10.1046/j.1468-2982.2003.00595.x ◽

2003 ◽

Vol 23 (9) ◽

pp. 929-930 ◽

Cited By ~ 12

Author(s):

C Lisotto ◽

F Mainardi ◽

F Maggioni ◽

G Zanchin

Keyword(s):

Case Report ◽

Cluster Headache ◽

Hemicrania Continua ◽

Paroxysmal Hemicrania ◽

Simultaneous Occurrence ◽

Headache Disorders ◽

Sunct Syndrome ◽

First Case ◽

Episodic Cluster Headache ◽

Male Patients

The trigeminal autonomic cephalgias (TACs) are characterized by short-lasting unilateral headaches with autonomic features (1). They include four headache disorders, cluster headache (CH), paroxysmal hemicrania (PH), SUNCT syndrome and hemicrania continua (HC). The coexistence of different ipsilateral TACs in the same patient has been previously reported in six published cases (2-6). In five of these patients an association of CH and PH was noted (2-5). The two varieties of attacks occurred separately in three patients, while their simultaneous occurrence was observed in two cases. In another patient the successive occurrence of trigeminal neuralgia, SUNCT syndrome, PH and CH in one active headache period was noted (6). All the reported cases concerned male patients. We describe what we believe to be the first case of coexistence of two different contralateral TACs.

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Cluster headache in children and adolescents: Ten years of follow-up in three pediatric cases

Cephalalgia ◽

10.1177/0333102411418015 ◽

2011 ◽

Vol 31 (13) ◽

pp. 1409-1414 ◽

Cited By ~ 18

Author(s):

Marco A Arruda ◽

Lucas Bonamico ◽

Cleiber Stella ◽

Carlos A Bordini ◽

Marcelo E Bigal

Keyword(s):

Case Report ◽

Cluster Headache ◽

Spontaneous Remission ◽

Response To Therapy ◽

Case Examples ◽

The Third ◽

First Case ◽

Long Term Follow Up

Background: Cluster headache (CH) is a rare cause of headache in children. Onset before 12 years of age is unusual, and long-term follow-up of pediatric cases has been not reported. Objectives: To report three cases of CH with onset at childhood and at least ten years of follow-up. Methods: Case report. Results: The first case is that of a 12-year-old boy with episodic CH with unilateral pain and striking, bilateral autonomic manifestations, remitted for over eight years. The second case is unique in that it reports a case of chronic CH in a 13-year-old boy with Down syndrome. The third case is that of a 9-year-old girl with episodic CH with remissions of 2 and 5 years. All cases had prominent autonomic features. The frequency and duration of the attacks were similar to those that have been reported in adults. Good response to indomethacin was obtained in two cases, although tolerability issues occurred in one. Conclusion: Sustained, long-term, medical and/or spontaneous remission occurs in CH of early onset. The phenotype and response to therapy in children, at least in these case examples, are similar to equivalent observations in adult patients with CH.

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Cluster Headache and Mucocele: A First Case Report

Journal of Clinical Case Reports ◽

10.4172/2165-7920.1000887 ◽

2016 ◽

Vol 6 (11) ◽

Cited By ~ 1

Author(s):

Mariangela Panebianco ◽

Andrea Giorgetti ◽

Maria Vittoria Calloni

Keyword(s):

Case Report ◽

Cluster Headache ◽

First Case

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Cluster-Like Headache Secondary to Sphenoid Sinus Mucocele

Case Reports in Neurological Medicine ◽

10.1155/2018/5850286 ◽

2018 ◽

Vol 2018 ◽

pp. 1-3

Author(s):

Mariana Branco ◽

Rita Rodrigues ◽

Marta Lopes ◽

Luís Ruano

Keyword(s):

Case Report ◽

Cluster Headache ◽

Effective Treatment ◽

Trigeminal Nerve ◽

Direct Contact ◽

Sphenoid Sinus ◽

Great Majority ◽

Trigeminovascular System ◽

First Case

Background. The great majority of cases of cluster headache (CH) are primary, but there are several reported cases of CH secondary to underlying structural lesions. The identification of these lesions is crucial for the achievement of an effective treatment and favorable outcome, although the determination of a cause-effect relationship between the two entities may be challenging. Case Report. We present the first case of CH secondary to sphenoid sinus mucocele. Discussion. This case reinforces the need to perform neuroimaging studies in CH patients in order to identify lesions that can constitute its cause, especially if atypical features are present. Activation of the trigeminovascular system due to direct contact between the lesion and the trigeminal nerve or by local edema and inflammation possibly plays a role in the pathophysiology of this CH secondary to sphenoid sinus mucocele.

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Urinary Tract Involvement in Epidermolysis Bullosa

PEDIATRICS ◽

10.1542/peds.51.5.938 ◽

1973 ◽

Vol 51 (5) ◽

pp. 938-941

Author(s):

Ronald C. Kretkowski

Keyword(s):

Case Report ◽

Urinary Tract ◽

Epidermolysis Bullosa ◽

Skin Disease ◽

The Body ◽

Early Infancy ◽

Clinical Feature ◽

First Case ◽

Mucous Membranes ◽

Tract Involvement

Epidermolysis bullosa is an uncommon skin disease which manifests itself at birth or in early infancy. It is characterized by blister formation occurring spontaneously or after friction or slight trauma.1 Involvement of the skin and mucous membranes is the chief clinical feature in this disease. Various systems of the body are affected either primarily or secondary to bullae and scarring of their mucous membranes. These include the conjunctiva of the eye, the mouth, the larynx, the esophagus, and the lung secondary to dysphagic pneumonitis.2 Herein is reported the first case of genitourinary tract involvement found in this disease. Case Report

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