Factor VIIa: on its own and loving it

Blood ◽  
2012 ◽  
Vol 120 (4) ◽  
pp. 705-707 ◽  
Author(s):  
Dougald M. Monroe
Keyword(s):  
Mathematical Models ◽  
Mechanism Of Action ◽  
Factor Viia ◽  
Experimental Studies ◽  
High Dose ◽  
Dose Factor

In this issue of Blood, Shibeko et al have used a variety of experimental studies and mathematical models to investigate the mechanism of action of high-dose factor VIIa as a bypassing agent in hemophilia.1

scholarly journals Mechanism of Action of High-Dose Factor VIIa

2003 ◽  
Vol 23 (1) ◽  
pp. 8-9 ◽  
Author(s):  
Dougald M. Monroe ◽  
Harold R. Roberts
Keyword(s):  
Mechanism Of Action ◽  
Factor Viia ◽  
High Dose ◽  
Dose Factor

scholarly journals High dose factor VIIa improves clot structure and stability in a model of haemophilia B

2005 ◽  
Vol 131 (5) ◽  
pp. 645-655 ◽  
Author(s):  
Alisa S. Wolberg ◽  
Geoffrey A. Allen ◽  
Dougald M. Monroe ◽  
Ulla Hedner ◽  
Harold R. Roberts ◽  
...  
Keyword(s):  
Factor Viia ◽  
High Dose ◽  
Structure And Stability ◽  
Haemophilia B ◽  
Clot Structure ◽  
Dose Factor

scholarly journals Of mitogens and morphogens: modelling Sonic Hedgehog mechanisms in vertebrate development

2020 ◽  
Vol 375 (1809) ◽  
pp. 20190660 ◽  
Author(s):  
Ian Groves ◽  
Marysia Placzek ◽  
Alexander G. Fletcher
Keyword(s):  
Mathematical Modelling ◽  
Mathematical Models ◽  
Sonic Hedgehog ◽  
Mechanism Of Action ◽  
Concentration Gradient ◽  
Experimental Studies ◽  
Theoretical Framework ◽  
Vertebrate Development ◽  
Complex Mechanism ◽  
Proliferation And Differentiation

Sonic Hedgehog (Shh) Is a critical protein in vertebrate development, orchestrating patterning and growth in many developing systems. First described as a classic morphogen that patterns tissues through a spatial concentration gradient, subsequent studies have revealed a more complex mechanism, in which Shh can also regulate proliferation and differentiation. While the mechanism of action of Shh as a morphogen is well understood, it remains less clear how Shh might integrate patterning, proliferation and differentiation in a given tissue, to ultimately direct its morphogenesis. In tandem with experimental studies, mathematical modelling can help gain mechanistic insights into these processes and bridge the gap between Shh-regulated patterning and growth, by integrating these processes into a common theoretical framework. Here, we briefly review the roles of Shh in vertebrate development, focusing on its functions as a morphogen, mitogen and regulator of differentiation. We then discuss the contributions that modelling has made to our understanding of the action of Shh and highlight current challenges in using mathematical models in a quantitative and predictive way. This article is part of a discussion meeting issue ‘Contemporary morphogenesis’.

The action of high-dose factor VIIa (FVIIa) in a cell-based model of hemostasis

2001 ◽  
Vol 38 ◽  
pp. 6-9 ◽  
Author(s):  
Maureane Hoffman ◽  
Dougald M Monroe
Keyword(s):  
Factor Viia ◽  
High Dose ◽  
A Cell ◽  
Dose Factor

scholarly journals Manipulation of prothrombin concentration improves response to high-dose factor VIIa in a cell-based model of haemophilia

2006 ◽  
Vol 134 (3) ◽  
pp. 314-319 ◽  
Author(s):  
Geoffrey A. Allen ◽  
Maureane Hoffman ◽  
Harold R. Roberts ◽  
Dougald M. Monroe
Keyword(s):  
Factor Viia ◽  
High Dose ◽  
A Cell ◽  
Dose Factor

scholarly journals High-dose factor VIIa increases initial thrombin generation and mediates faster platelet activation in thrombocytopenia-like conditions in a cell-based model system

2001 ◽  
Vol 114 (1) ◽  
pp. 114-120 ◽  
Author(s):  
Marianne Kjalke ◽  
Mirella Ezban ◽  
Dougald M. Monroe ◽  
Maureane Hoffman ◽  
Harold R. Roberts ◽  
...  
Keyword(s):  
Platelet Activation ◽  
Thrombin Generation ◽  
Factor Viia ◽  
Model System ◽  
High Dose ◽  
A Cell ◽  
Dose Factor

Platelet activity of high-dose factor VIIa is independent of tissue factor

1997 ◽  
Vol 99 (3) ◽  
pp. 542-547 ◽  
Author(s):  
Dougald M. Monroe ◽  
Maureane Hoffman ◽  
Julie A. Oliver ◽  
Harold R. Roberts
Keyword(s):  
Tissue Factor ◽  
Factor Viia ◽  
High Dose ◽  
Platelet Activity ◽  
Dose Factor

The action of high-dose factor VIIa (FVIIa) in a cell-based model of hemostasis

2003 ◽  
Vol 49 (1) ◽  
pp. 14-21 ◽  
Author(s):  
Maureane Hoffman ◽  
Dougald M. Monroe
Keyword(s):  
Factor Viia ◽  
High Dose ◽  
A Cell ◽  
Dose Factor
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