scholarly journals Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection

Blood ◽  
2014 ◽  
Vol 123 (1) ◽  
pp. 61-69 ◽  
Author(s):  
Chuka A. Didigu ◽  
Craig B. Wilen ◽  
Jianbin Wang ◽  
Jennifer Duong ◽  
Anthony J. Secreto ◽  
...  
Keyword(s):  
T Cells ◽  
Zinc Finger ◽  
Cd4 T Cells ◽  
Zinc Finger Nuclease ◽  
Zinc Finger Nucleases ◽  
Functional Cure ◽  
Key Points ◽  
Hiv 1 ◽  
Resistant Cells

Key PointsZinc-finger nucleases simultaneously and permanently inactivate HIV coreceptors ccr5 and cxcr4 resulting in HIV-resistant CD4+ T cells. These HIV-resistant cells may be used to achieve a functional cure for HIV in humans.

scholarly journals Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

2008 ◽  
Vol 26 (7) ◽  
pp. 808-816 ◽  
Author(s):  
Elena E Perez ◽  
Jianbin Wang ◽  
Jeffrey C Miller ◽  
Yann Jouvenot ◽  
Kenneth A Kim ◽  
...  
Keyword(s):  
T Cells ◽  
Genome Editing ◽  
Zinc Finger ◽  
Cd4 T Cells ◽  
Zinc Finger Nucleases ◽  
Hiv 1

Zinc finger nuclease: a new approach for excising HIV-1 proviral DNA from infected human T cells

2014 ◽  
Vol 41 (9) ◽  
pp. 5819-5827 ◽  
Author(s):  
Xiying Qu ◽  
Pengfei Wang ◽  
Donglin Ding ◽  
Xiaohui Wang ◽  
Gongmin Zhang ◽  
...  
Keyword(s):  
T Cells ◽  
Zinc Finger ◽  
Zinc Finger Nuclease ◽  
New Approach ◽  
Proviral Dna ◽  
Human T Cells ◽  
Hiv 1

scholarly journals Engineering HIV-Resistant Human CD4+ T Cells with CXCR4-Specific Zinc-Finger Nucleases

2011 ◽  
Vol 7 (4) ◽  
pp. e1002020 ◽  
Author(s):  
Craig B. Wilen ◽  
Jianbin Wang ◽  
John C. Tilton ◽  
Jeffrey C. Miller ◽  
Kenneth A. Kim ◽  
...  
Keyword(s):  
T Cells ◽  
Zinc Finger ◽  
Cd4 T Cells ◽  
Zinc Finger Nucleases

scholarly journals Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells

2013 ◽  
Vol 41 (16) ◽  
pp. 7771-7782 ◽  
Author(s):  
Xiying Qu ◽  
Pengfei Wang ◽  
Donglin Ding ◽  
Lin Li ◽  
Haibo Wang ◽  
...  
Keyword(s):  
T Cells ◽  
Zinc Finger ◽  
Zinc Finger Nucleases ◽  
Proviral Dna ◽  
Human T Cells ◽  
Latently Infected ◽  
Hiv 1
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