scholarly journals Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GVHD

Blood ◽  
2015 ◽  
Vol 126 (4) ◽  
pp. 437-444 ◽  
Author(s):  
Martin Chopra ◽  
Andreas Brandl ◽  
Daniela Siegmund ◽  
Anja Mottok ◽  
Viktoria Schäfer ◽  
...  
Keyword(s):  
Cell Death ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Human Immunoglobulin ◽  
Intestinal Cell ◽  
Hematopoietic Stem ◽  
Key Points

Key Points Fn14 activation is involved in intestinal apoptosis after allo-HCT and contributes to gastrointestinal GVHD. Fn14 blockade with an ADCC-defective human immunoglobulin G1 antibody reduces GVHD severity without modulating GVL responses.

scholarly journals The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation

Blood ◽  
2014 ◽  
Vol 124 (7) ◽  
pp. 1174-1182 ◽  
Author(s):  
Ying Taur ◽  
Robert R. Jenq ◽  
Miguel-Angel Perales ◽  
Eric R. Littmann ◽  
Sejal Morjaria ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Bacterial Diversity ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Intestinal Tract ◽  
Hematopoietic Stem ◽  
Key Points

Key Points Intestinal diversity is predictive of mortality in allo-HSCT.

scholarly journals Alternative donors for allogeneic hematopoietic stem cell transplantation in poor-risk AML in CR1

2017 ◽  
Vol 1 (7) ◽  
pp. 477-485 ◽  
Author(s):  
Jurjen Versluis ◽  
Myriam Labopin ◽  
Annalisa Ruggeri ◽  
Gerard Socie ◽  
Depei Wu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Poor Risk ◽  
Key Points

Key Points The preferred donor for patients with poor-risk AML in CR1 proceeding to alloHSCT include MRD or 10/10 MUD. Alternative donors are 9/10 MUD, UCB grafts, and especially haplo, but sufficient numbers and follow-up to define a hierarchy are lacking.

scholarly journals Quantitation of hematogones at the time of engraftment is a useful prognostic indicator in allogeneic hematopoietic stem cell transplantation

Blood ◽  
2013 ◽  
Vol 121 (5) ◽  
pp. 840-848 ◽  
Author(s):  
Takahiro Shima ◽  
Toshihiro Miyamoto ◽  
Yoshikane Kikushige ◽  
Yasuo Mori ◽  
Kenjiro Kamezaki ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Allogeneic Stem Cell Transplantation ◽  
Prognostic Indicator ◽  
Hematopoietic Stem ◽  
Key Points

Key Points Quantitation of hematogones at engraftment is useful to predict prognosis of patients treated with allogeneic stem cell transplantation.

scholarly journals Multiple mismatches at the low expression HLA loci DP, DQ, and DRB3/4/5 associate with adverse outcomes in hematopoietic stem cell transplantation

Blood ◽  
2013 ◽  
Vol 121 (22) ◽  
pp. 4603-4610 ◽  
Author(s):  
Marcelo A. Fernández-Viña ◽  
John P. Klein ◽  
Michael Haagenson ◽  
Stephen R. Spellman ◽  
Claudio Anasetti ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Clinical Outcome ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Adverse Outcomes ◽  
Hematopoietic Stem ◽  
Key Points ◽  
Low Expression

Key Points Three or more mismatches at the Low Expression Loci may adversely affect clinical outcome after 7/8 matched transplantation. Match grade at the Low Expression HLA Loci may be considered to select 7/8 donors with potentially lower posttransplant risks.

scholarly journals Matching for the MICA-129 polymorphism is beneficial in unrelated hematopoietic stem cell transplantation

Blood ◽  
2016 ◽  
Vol 128 (26) ◽  
pp. 3169-3176 ◽  
Author(s):  
Daniel Fuerst ◽  
Christine Neuchel ◽  
Dietger Niederwieser ◽  
Donald Bunjes ◽  
Martin Gramatzki ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Transplant Patients ◽  
Key Points

Key Points MICA-129 matching improves survival in uHSCT. MICA-129 mismatches were observed in 6.7% of all transplant patients.

scholarly journals The value of allogeneic and autologous hematopoietic stem cell transplantation in prognostically favorable acute myeloid leukemia with double mutant CEBPA

Blood ◽  
2013 ◽  
Vol 122 (9) ◽  
pp. 1576-1582 ◽  
Author(s):  
Richard F. Schlenk ◽  
Erdogan Taskesen ◽  
Yvette van Norden ◽  
Jürgen Krauter ◽  
Arnold Ganser ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Remission Rate ◽  
Allogeneic Transplantation ◽  
Hematopoietic Stem ◽  
Free Survival ◽  
Key Points

Key Points In AML with bialleleic CEBPA-mut relapse-free survival was improved by allogeneic and autologous hematopoietic stem cell transplantation. In relapsed patients second complete remission rate was high and survival was favorable after an allogeneic transplantation.

scholarly journals Identification of a permissible HLA mismatch in hematopoietic stem cell transplantation

Blood ◽  
2014 ◽  
Vol 123 (8) ◽  
pp. 1270-1278 ◽  
Author(s):  
Marcelo A. Fernandez-Viña ◽  
Tao Wang ◽  
Stephanie J. Lee ◽  
Michael Haagenson ◽  
Mahmoud Aljurf ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Transplant Outcome ◽  
Key Points ◽  
Single Allele

Key Points Mismatches in alleles C*03:03/C*03:04 were most frequent (68.7%) among the transplants with a single allele level mismatch in HLA-C. The 7/8 C*03:03/C*03:04 mismatch group was not significantly different from the 8/8 HLA matched transplants in any transplant outcome.

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