scholarly journals Distinct signaling programs control human hematopoietic stem cell survival and proliferation

Blood ◽  
2017 ◽  
Vol 129 (3) ◽  
pp. 307-318 ◽  
Author(s):  
David J. H. F. Knapp ◽  
Colin A. Hammond ◽  
Nima Aghaeepour ◽  
Paul H. Miller ◽  
Davide Pellacani ◽  
...  
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Cell Survival ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Key Points ◽  
Stem Cell Survival ◽  
Human Hscs ◽  
Signaling Activity ◽  
Cell Survival And Proliferation

Key Points Human HSCs show higher tonic signaling activity in multiple pathways than MPPs. Growth factor–activated AKT and β-catenin in human HSCs regulate their survival and mitogenesis.

scholarly journals Prostaglandin E2 Increases Hematopoietic Stem Cell Survival and Accelerates Hematopoietic Recovery After Radiation Injury

Stem Cells ◽  
2013 ◽  
Vol 31 (2) ◽  
pp. 372-383 ◽  
Author(s):  
Rebecca L. Porter ◽  
Mary A. Georger ◽  
Olga Bromberg ◽  
Kathleen E. McGrath ◽  
Benjamin J. Frisch ◽  
...  
Keyword(s):  
Stem Cell ◽  
Prostaglandin E2 ◽  
Cell Survival ◽  
Hematopoietic Stem Cell ◽  
Radiation Injury ◽  
Hematopoietic Stem ◽  
Hematopoietic Recovery ◽  
Stem Cell Survival

scholarly journals Pontin is essential for murine hematopoietic stem cell survival

Haematologica ◽  
2012 ◽  
Vol 97 (9) ◽  
pp. 1291-1294 ◽  
Author(s):  
O. Bereshchenko ◽  
E. Mancini ◽  
L. Luciani ◽  
A. Gambardella ◽  
C. Riccardi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Survival ◽  
Murine Hematopoietic Stem Cell

scholarly journals HDAC8 regulates long-term hematopoietic stem-cell maintenance under stress by modulating p53 activity

Blood ◽  
2017 ◽  
Vol 130 (24) ◽  
pp. 2619-2630 ◽  
Author(s):  
Wei-Kai Hua ◽  
Jing Qi ◽  
Qi Cai ◽  
Emily Carnahan ◽  
Maria Ayala Ramirez ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Key Points ◽  
Cell Maintenance

Key Points HDAC8 plays a key role in maintaining long-term hematopoietic repopulation. HDAC8 modulates p53 activity to ensure LT-HSC cell survival under stress.

scholarly journals UFMylation of MRE11 is essential for maintenance of telomere length and hematopoietic stem cell survival

2019 ◽  
Author(s):  
Lara Lee ◽  
Ana Belen Perez Oliva ◽  
Dmitri Churikov ◽  
Elena Martinez-Balsalobre ◽  
Joshua Peter ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Telomere Length ◽  
Hematopoietic Stem Cell ◽  
Strand Break ◽  
Telomere Maintenance ◽  
Hematopoietic Stem ◽  
Telomere Protein ◽  
Stem Cell Survival

AbstractGenetic studies using knockout mouse models provide strong evidence for the essential role of the ubiquitin-like protein UFM1 for hematopoiesis, especially erythroid development, yet its biological roles in this process are largely unknown. Here we have identified a UFL1-dependent UFMylation of the MRE11 nuclease on the K281 and K282 residues. We show that Hela cells lacking the specific UFM1 E3 ligase display severe telomere shortening. We further demonstrate either by deleting UFM1 or by mutating MRE11 UFMylation sites that preventing MRE11 UFMylation impacts its interaction with the telomere protein TRF2. However, the MRE11 function in double-strand-break repair remains intact. We validate these results in vivo by showing that Zebrafish knockouts for the genes ufl1 and ufm1 have shorter telomeres in hematopoietic cells. Here we present UFMylation has a new mechanisms of regulation for telomere length maintenance with a role in hematopoiesis.Key pointsModification of MRE11 by UFM1 regulates telomere maintenance and cell death in HSCsScientific categoryUFMylation, telomere maintenance, hematopoietic stem cell survival.

scholarly journals Gata2 −77 enhancer regulates adult hematopoietic stem cell survival

Leukemia ◽  
2020 ◽  
Author(s):  
Xiaona You ◽  
Yuan-I Chang ◽  
Guangyao Kong ◽  
Erik A. Ranheim ◽  
Yun Zhou ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Survival

scholarly journals UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival

2021 ◽  
Vol 7 (39) ◽  
Author(s):  
Lara Lee ◽  
Ana Belen Perez Oliva ◽  
Elena Martinez-Balsalobre ◽  
Dmitri Churikov ◽  
Joshua Peter ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Telomere Length ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Survival

Bone marrow adipocytes support hematopoietic stem cell survival

2017 ◽  
Vol 233 (2) ◽  
pp. 1500-1511 ◽  
Author(s):  
Domenico Mattiucci ◽  
Giulia Maurizi ◽  
Valerio Izzi ◽  
Lorenzo Cenci ◽  
Marco Ciarlantini ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Cell Survival ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Bone Marrow Adipocytes ◽  
Stem Cell Survival
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