scholarly journals Hematopoiesis and the bacterial microbiome

Blood ◽  
2018 ◽  
Vol 132 (6) ◽  
pp. 559-564 ◽  
Author(s):  
Hannah Yan ◽  
Megan T. Baldridge ◽  
Katherine Y. King
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Current Understanding ◽  
Intestinal Microbiome ◽  
Antibiotic Exposure ◽  
Gut Dysbiosis ◽  
Bacterial Microbiome ◽  
Inflammatory Bowel

AbstractRecent studies have revealed that the intestinal bacterial microbiome plays an important role in the regulation of hematopoiesis. A correlation between adverse hematologic effects and imbalance of the intestinal microbiome, or dysbiosis, is evident in several human conditions, such as inflammatory bowel disease, obesity, and, critically, in the setting of antibiotic exposure. Here we review the effects of gut dysbiosis on the hematological compartment and our current understanding of the mechanisms through which changes in the bacterial microbiome affect hematopoiesis.

scholarly journals A murine model of pediatric inflammatory bowel disease causes microbiota-gut-brain axis deficits in adulthood

2020 ◽  
Vol 319 (3) ◽  
pp. G361-G374 ◽  
Author(s):  
Eloisa Salvo ◽  
Patricia Stokes ◽  
Ciara E. Keogh ◽  
Ingrid Brust-Mascher ◽  
Carly Hennessey ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Early Life ◽  
Low Dose ◽  
Behavioral Deficits ◽  
Colonic Inflammation ◽  
Gut Dysbiosis ◽  
Pediatric Inflammatory Bowel Disease ◽  
Adult Mice ◽  
Inflammatory Bowel

Here we describe long-lasting impacts on the microbiota-gut-brain (MGB) axis following administration of low-dose dextran sodium sulfate (DSS) to weaning mice (P21), including gut dysbiosis, colonic inflammation, and brain/behavioral deficits in adulthood (P56). Early-life DSS leads to acute colonic inflammation, similar to adult mice; however, it results in long-lasting deficits in the MGB axis in adulthood (P56), in contrast to the transient deficits seen in adult DSS. This model highlights the unique features of pediatric inflammatory bowel disease.

26 THE INTESTINAL MICROBIOME IN INFLAMMATORY BOWEL DISEASE ACROSS THE PEDIATRIC AGE RANGE

2019 ◽  
Vol 156 (3) ◽  
pp. S102-S103
Author(s):  
Maire A. Conrad ◽  
Kyle Bittinger ◽  
Yue Ren ◽  
Jessica Breton ◽  
Nina Devas ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Intestinal Microbiome ◽  
Pediatric Age ◽  
Inflammatory Bowel ◽  
Age Range

scholarly journals Analyzing the intestinal microbiome in inflammatory bowel disease: From RNA to multiomics

JGH Open ◽  
2020 ◽  
Vol 4 (5) ◽  
pp. 779-781
Author(s):  
Bron Lett ◽  
Samuel Costello ◽  
Ian Roberts‐Thomson
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Intestinal Microbiome ◽  
Inflammatory Bowel

scholarly journals Peripartum Antibiotics Promote Gut Dysbiosis, Loss of Immune Tolerance, and Inflammatory Bowel Disease in Genetically Prone Offspring

Cell Reports ◽  
2017 ◽  
Vol 20 (2) ◽  
pp. 491-504 ◽  
Author(s):  
Jun Miyoshi ◽  
Alexandria M. Bobe ◽  
Sawako Miyoshi ◽  
Yong Huang ◽  
Nathaniel Hubert ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Immune Tolerance ◽  
Bowel Disease ◽  
Gut Dysbiosis ◽  
Inflammatory Bowel

Su1345 Patterns of Antibiotic Exposure and Clinical Disease Activity in Inflammatory Bowel Disease: A 4 Year Prospective Study

2014 ◽  
Vol 146 (5) ◽  
pp. S-442
Author(s):  
Jana G. Hashash ◽  
Claudia M. Ramos Rivers ◽  
Miguel Regueiro ◽  
Arthur Barrie ◽  
Marc Schwartz ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Prospective Study ◽  
Disease Activity ◽  
Bowel Disease ◽  
Clinical Disease ◽  
Antibiotic Exposure ◽  
Clinical Disease Activity ◽  
Inflammatory Bowel

scholarly journals Possible methods for evaluation of hydrogen sulfide toxicity against lactic acid bacteria

2019 ◽  
Vol 9 (4) ◽  
pp. 4066-4069 ◽  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Hydrogen Sulfide ◽  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Bowel Disease ◽  
Inhibitory Concentration ◽  
Agar Plate ◽  
Intestinal Microbiome ◽  
Sulfate Reducing ◽  
Inflammatory Bowel

An integral part of the intestinal microbiota is undoubtedly formed by lactic acid bacteria (LAB). Their presence in the digestive tract is essential for its proper functioning. During inflammatory bowel disease, such as ulcerative colitis (UC), LAB occurrence is reduced while sulfate-reducing bacteria (SRB) occur widely in the intestine resulting in an increase of their metabolite, hydrogen sulfide. Inhibitory concentration and mechanism of action of hydrogen sulfide on LAB are not fully known yet. The aim of this paper is to find the proper testing methods for evaluation of the interaction between hydrogen sulfide and lactic acid bacteria, including minimal inhibitory concentration (MIC) determination. Spectrophotometric, colorimetric, agar plate methods and combination of these methods were tested. Thousands of people from all over the world are affected by inflammatory bowel disease every year. The gained results could help to understand and improve the stability of intestinal microbiome, improve the treatment of bowel inflammation diseases, or prevent bowel disease altogether

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