The Significance of Iron Turnover in the Control of Iron Absorption

Abstract Following acute blood loss, there is a 4- to 5-day lag before any demonstrable change in plasma iron kinetics. Then there is a shortened Fe59 T½ and transient fall in the plasma iron. Associated with this is a decrease in the intestinal content of iron and an increased absorption of iron. We suggest the iron content of the epithelial cell is important in the regulation of its ability to absorb iron. The intestinal iron content is in turn closely controlled by the plasma iron turnover.

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A model of intestinal iron absorption and plasma iron kinetics: Optimal parameter estimates for normal dogs

Computers and Biomedical Research ◽

10.1016/0010-4809(84)90006-5 ◽

1984 ◽

Vol 17 (1) ◽

pp. 55-70 ◽

Cited By ~ 10

Author(s):

Michael H. Nathanson ◽

Gordon D. McLaren ◽

Gerald M. Saidel

Keyword(s):

Iron Absorption ◽

Optimal Parameter ◽

Parameter Estimates ◽

Intestinal Iron Absorption ◽

Plasma Iron ◽

Iron Kinetics

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Iron homeostasis in beta-thalassemic mice

Blood ◽

10.1182/blood.v70.5.1462.bloodjournal7051462 ◽

1987 ◽

Vol 70 (5) ◽

pp. 1462-1465

Author(s):

DB Van Wyck ◽

ME Tancer ◽

RA Popp

Keyword(s):

Iron Content ◽

Iron Homeostasis ◽

Beta Thalassemia ◽

Plasma Iron ◽

Adult Mice ◽

Tissue Iron ◽

Moderate Anemia ◽

Iron Kinetics ◽

And Control ◽

Iron Exchange

To explore the pathogenesis of nontransfusional iron overload in iron- loading anemia, we examined features of external iron exchange, internal iron kinetics, and tissue iron burden in adult mice with inherited gene-deletion beta-thalassemia. Mice homozygous for beta- thalassemia display moderate anemia, reticulocytosis, and shortened red cell survival, whereas heterozygous carriers appear hematologically normal. Quantitative iron determination revealed that iron content and concentration in liver, spleen, and kidney, but not heart, were far higher (P less than .01) in 15-to 35-week old homozygous thalassemic mice than in age-matched normal and heterozygous controls; of these tissues, iron content increased with age only in kidneys (P = .01) of homozygous affected mice. Although plasma iron levels were only minimally elevated in homozygotes, plasma iron turnover was threefold greater (P less than .001) than that seen in heterozygote controls. Nevertheless hyperabsorption of enteric radioiron, discernible among homozygous thalassemic mice as late as 6 to 8 weeks after birth, was not observed in older mice, additionally, thalassemic and control mice at 18 to 34 weeks showed comparable iron excretion after intravenous radioiron. We conclude that adult mice with beta-thalassemia regain balanced external iron exchange, despite substantial tissue iron excess and accelerated internal iron transit.

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Iron homeostasis in beta-thalassemic mice

Blood ◽

10.1182/blood.v70.5.1462.1462 ◽

1987 ◽

Vol 70 (5) ◽

pp. 1462-1465 ◽

Cited By ~ 18

Author(s):

DB Van Wyck ◽

ME Tancer ◽

RA Popp

Keyword(s):

Iron Content ◽

Iron Homeostasis ◽

Beta Thalassemia ◽

Plasma Iron ◽

Adult Mice ◽

Tissue Iron ◽

Moderate Anemia ◽

Iron Kinetics ◽

And Control ◽

Iron Exchange

Abstract To explore the pathogenesis of nontransfusional iron overload in iron- loading anemia, we examined features of external iron exchange, internal iron kinetics, and tissue iron burden in adult mice with inherited gene-deletion beta-thalassemia. Mice homozygous for beta- thalassemia display moderate anemia, reticulocytosis, and shortened red cell survival, whereas heterozygous carriers appear hematologically normal. Quantitative iron determination revealed that iron content and concentration in liver, spleen, and kidney, but not heart, were far higher (P less than .01) in 15-to 35-week old homozygous thalassemic mice than in age-matched normal and heterozygous controls; of these tissues, iron content increased with age only in kidneys (P = .01) of homozygous affected mice. Although plasma iron levels were only minimally elevated in homozygotes, plasma iron turnover was threefold greater (P less than .001) than that seen in heterozygote controls. Nevertheless hyperabsorption of enteric radioiron, discernible among homozygous thalassemic mice as late as 6 to 8 weeks after birth, was not observed in older mice, additionally, thalassemic and control mice at 18 to 34 weeks showed comparable iron excretion after intravenous radioiron. We conclude that adult mice with beta-thalassemia regain balanced external iron exchange, despite substantial tissue iron excess and accelerated internal iron transit.

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CORRECTION OF METABOLIC INDICATORS OF ERYTHROCYTES AND THE STRUCTURE MYOCARDIUM AFTER ACUTE BLOOD LOSS USING AN OZONIZED ERYTHROCYTAL MASS

Tsitologiya ◽

10.31116/tsitol.2018.02.03 ◽

2018 ◽

Vol 60 (2) ◽

pp. 89-95 ◽

Cited By ~ 1

Author(s):

A. V. Deryugina ◽

◽

G. A. Boyarinov ◽

I. S. Simutis ◽

V. O. Nikolskiy ◽

...

Keyword(s):

Blood Loss ◽

Acute Blood Loss

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Some aspects of the development of blood donation in domestic health care

Vrač skoroj pomoŝi (Emergency Doctor) ◽

10.33920/med-02-2001-08 ◽

2020 ◽

pp. 61-68

Author(s):

M. Sharavina

Keyword(s):

Health Care ◽

Blood Loss ◽

Blood Donation ◽

Regulatory Framework ◽

Blood Transfusions ◽

Acute Blood Loss ◽

Donated Blood

The first successful blood transfusions were aimed at saving lives of patients with acute blood loss, application of donated blood is much wider today. Expansion of informational work with donors, including development of understanding in a donor concerning importance of the donor program in patient’s life, as well as creation of the Blood Service, which is responsible for promotion, collection of blood and its components, their storage and transportation, contributes to the development of regular and ongoing donation. The author reviewed the regulatory framework for blood donation.

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