Effects of Speech and Speech and Sign Instruction on Oral Language Learning and Generalization of Action + Object Combinations by Down's Syndrome Children

1984 ◽  
Vol 49 (3) ◽  
pp. 293-302 ◽  
Author(s):  
Mary Ann Romski ◽  
Kenneth F. Ruder
Keyword(s):  
Language Learning ◽  
Oral Language ◽  
Early Stage ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Treatment Conditions ◽  
Linguistic System ◽  
Object Relational ◽  
Sign Conditions ◽  
Level Performance

This study was designed to compare the effects of speech and speech-plus-sign stimulation during comprehension treatment on the oral language learning and generalization of action + object relational meanings. Ten home-reared Down's syndrome children in Early Stage I received concurrent comprehension treatment in Speech and Speech-Sign conditions using a miniature linguistic system. Upon attainment of criterion level performance in both conditions, generalization tasks were administered to measure the effects of the comprehension treatment on the comprehension and the production of treated and untreated action + object combinations. The results obtained from this study indicated that the two treatment conditions did not differ significantly for either learning or generalization. The data did, however, indicate that individual patterns of acquisition were evident among the children. Caution is advised concerning the automatic adoption or rejection of manual sign as part of oral language intervention programs.

scholarly journals Desenvolvimento da Linguagem Oral e da Memória de Trabalho em Indivíduos com Síndrome de Down por meio da Recontagem de Histórias / Development of Oral Language and Working Memory in Individuals with Down's Syndrome by Recounting Histories

2019 ◽  
Vol 13 (46) ◽  
pp. 212-230
Author(s):  
Amanda Avelar Lima ◽  
Carla Salati Almeida Ghirello-Pires
Keyword(s):  
Working Memory ◽  
Oral Language ◽  
Down's Syndrome ◽  
Down’S Syndrome

O objetivo foi analisar o efeito da expansão da linguagem oral em indivíduos com Síndrome de Down, através da avaliação e intervenção da memória de trabalho, por meio da recontagem de histórias. Os participantes foram selecionados no Laboratório de Estudos e Pesquisa em Neurolinguística (LAPEN), localizado na Universidade Estadual da Bahia (UESB) em Vitória da Conquista - Bahia, sendo 4 indivíduos com Síndrome de Down com 8 anos (AR e SB) e 12 anos (CP e LR), sexo feminino. A pesquisa contou com três fases: a avaliação inicial da memória de trabalho; a estimulação da memória de trabalho e da linguagem, através da contagem e recontagem de histórias; e a avaliação final da memória de trabalho. Os resultados indicaram melhores desempenhos dos participantes na avaliação final da memória de trabalho em comparação à avaliação inicial. As evidencias apontaram que o processo interventivo, através das narrativas, favoreceu um melhor desempenho na memória de trabalho e na expansão linguística.

scholarly journals Chromosome abnormalities in Down's syndrome patients with acute leukemia

Blood ◽  
1981 ◽  
Vol 58 (3) ◽  
pp. 459-466 ◽  
Author(s):  
Y Kaneko ◽  
JD Rowley ◽  
D Variakojis ◽  
RR Chilcote ◽  
JW Moohr ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Early Stage ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Giemsa Stain ◽  
Chromosome Abnormalities ◽  
Leukemic Cells ◽  
Myeloid Differentiation ◽  
Acute Nonlymphocytic Leukemia ◽  
Blast Cells

Chromosome and cytologic studies were performed on three Down's syndrome (DS) patients with acute nonlymphocytic leukemia (ANLL). All three patients had an aneuploid clone in their leukemic cells: 50, XX, +6, +19, +21, +22, +8, XX, +21, and 47,XY, +8, - 21 +dic(21;21)(p13;p11). Every patient appeared to have acute undifferentiated leukemia when the blast cells were examined with Wright-Giemsa stain; cytochemistry studies, however, showed that the leukemic blasts were in an early stage of myeloid differentiation. The two patients with +8 had a preleukemic phase; the blast cells of the patient with an extra no. 19 and no.22 could not be differentiated morphologically from those of the two patients with an extra no. 8. Our findings and a review of data on 40 other patients suggest that most DS children with ANLL have hyperdiploidy, which is usually related to gains of C, F, and /or G chromosomes, and that the abnormalities of +8 and of +19, +22 in DS children may be associated with acute leukemia (AL) in an early stage of myeloid differentiation.

A Study of the spontaneous oral language of Down's syndrome children

1977 ◽  
Vol 24 (2) ◽  
pp. 86-94 ◽  
Author(s):  
R.J. Andrews ◽  
Jeanette G. Andrews
Keyword(s):  
Oral Language ◽  
Down's Syndrome ◽  
Down’S Syndrome

scholarly journals Chromosome abnormalities in Down's syndrome patients with acute leukemia

Blood ◽  
1981 ◽  
Vol 58 (3) ◽  
pp. 459-466 ◽  
Author(s):  
Y Kaneko ◽  
JD Rowley ◽  
D Variakojis ◽  
RR Chilcote ◽  
JW Moohr ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Early Stage ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Giemsa Stain ◽  
Chromosome Abnormalities ◽  
Leukemic Cells ◽  
Myeloid Differentiation ◽  
Acute Nonlymphocytic Leukemia ◽  
Blast Cells

Abstract Chromosome and cytologic studies were performed on three Down's syndrome (DS) patients with acute nonlymphocytic leukemia (ANLL). All three patients had an aneuploid clone in their leukemic cells: 50, XX, +6, +19, +21, +22, +8, XX, +21, and 47,XY, +8, - 21 +dic(21;21)(p13;p11). Every patient appeared to have acute undifferentiated leukemia when the blast cells were examined with Wright-Giemsa stain; cytochemistry studies, however, showed that the leukemic blasts were in an early stage of myeloid differentiation. The two patients with +8 had a preleukemic phase; the blast cells of the patient with an extra no. 19 and no.22 could not be differentiated morphologically from those of the two patients with an extra no. 8. Our findings and a review of data on 40 other patients suggest that most DS children with ANLL have hyperdiploidy, which is usually related to gains of C, F, and /or G chromosomes, and that the abnormalities of +8 and of +19, +22 in DS children may be associated with acute leukemia (AL) in an early stage of myeloid differentiation.

Cued recall in early-stage dementia in adults with Down's syndrome

2002 ◽  
Vol 46 (6) ◽  
pp. 472-483 ◽  
Author(s):  
D. A. Devenny ◽  
E. J. Zimmerli ◽  
P. Kittler ◽  
S. J. Krinsky-McHale
Keyword(s):  
Early Stage ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Cued Recall

Research in the Etiology of Down's Syndrome Intricacies and Pitfalls

1965 ◽  
Vol 14 (1) ◽  
pp. 93-96 ◽  
Author(s):  
Arnold R. Kaplan ◽  
Roland Fischer ◽  
Steven Zsako ◽  
Frances Griffin ◽  
Edward V. Glanville
Keyword(s):  
Rural Areas ◽  
Early Stage ◽  
Down's Syndrome ◽  
Infectious Agent ◽  
Down’S Syndrome ◽  
Epidemiological Studies ◽  
Chromosomal Anomaly ◽  
Chromosomal Anomalies ◽  
Normal Complement ◽  
Acrocentric Chromosomes

Cytological studies have shown that Down's syndrome (“ mongolism ”) is the result of a chromosomal anomaly which occurs either in one of the parent's germ cells or at a very early stage in (embryonic) development of the affected individual. The chromosomal anomaly involves the occurrence of a third number 21 chromosome, in addition to the normal complement of two, either separately (i. e., trisomy-21) or attached to one of the other acrocentric chromosomes (i. e., translocation to one of the chromosomes numbered 13-15 or 22 — Denver Report, 1960). Epidemiological studies have indicated that numerous factors are related to, and may affect, incidence of the chromosomal anomalies resulting in Down's syndrome. Studies by Collmann and Stoller (1962a, b) imply fluctuations of annual incidence with a 5-6 year periodicity, a higher incidence in urban compared to rural areas and a clusteting of affected births in certain geographic regions. Collmann and Stoller postulated an “ infectious agent, probably a virus ”, to account for their data. No connection, however, can yet be drawn between such a hypothesis and the established cytogenetic anomaly. Periodic fluctuations in incidence, which are characteristic of recurrent epidemics (Gordon, 1962), have also been reported for congenital anomalies other than Down's syndrome, such as anencephaly, spina bifida, and hydrocephaly (Collmann and Stoller, 1962b; Guthkelch, 1962; Alter, 1962; Slater, Watson and McDonald, 1964).

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