scholarly journals Time trends in surgery for lung cancer in France from 2005 to 2012: a nationwide study

2015 ◽  
Vol 46 (4) ◽  
pp. 1131-1139 ◽  
Author(s):  
Marie-Catherine Morgant ◽  
Pierre-Benoit Pagès ◽  
Bastien Orsini ◽  
Pierre-Emmanuel Falcoz ◽  
Pascal-Alexandre Thomas ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Time Trends ◽  
Pulmonary Resection ◽  
Early Stage ◽  
Small Cell ◽  
National Database ◽  
Small Cell Lung ◽  
Nationwide Study ◽  
Nodal Dissection ◽  
Systematic Nodal Dissection

The aim of this study was to assess the evolution of survival in patients treated surgically for non-small cell lung cancer (NSCLC) between 2005 and 2012.From January 2005 to December 2012, 34 006 patients underwent pulmonary resection for NSCLC and were included in the French national database Epithor. Patients' characteristics, procedures and survival were analysed. Survival according to the management was evaluated for each 2-year period separately: 2005–2006, 2007–2008, 2009–2010 and 2011–2012.The proportions of early-stage cancers and adenocarcinomas increased significantly over the periods. 3-year overall survival (OS) increased significantly from 80.5% for the first period to 81.4% for the last period. For the periods 2005–2006 and 2007–2008, 3-year OS was lower after segmentectomy than after lobectomy (77 and 73% versus 82 and 83%, respectively). For the periods 2009–2010 and 2011–2012, 3-year OS in the two sub-groups was similar. OS after bi-lobectomy or pneumonectomy was lower than after lobectomy for all periods analysed. Systematic nodal dissection increased OS for all periods. Chemotherapy but not radiotherapy improved OS in the first 12 postoperative months for all periods.Changes in histological type and stage linked to advances in surgical and medical practices since 2005 led to an increase in OS in patients with surgical-stage NSCLC.

scholarly journals Pattern of recurrence of pN2 non-small-cell lung cancer: should postoperative radiotherapy be reconsidered?

2020 ◽  
Vol 59 (1) ◽  
pp. 109-115 ◽  
Author(s):  
Kazuo Nakagawa ◽  
Yukihiro Yoshida ◽  
Masaya Yotsukura ◽  
Shun-ichi Watanabe
Keyword(s):  
Lung Cancer ◽  
Adjuvant Chemotherapy ◽  
Small Cell Lung Cancer ◽  
Postoperative Radiotherapy ◽  
Distant Recurrence ◽  
Small Cell ◽  
Small Cell Lung ◽  
Nodal Dissection ◽  
Systematic Nodal Dissection ◽  
Pattern Of Recurrence

Abstract OBJECTIVES The prognosis of patients with mediastinal lymph node (LN) metastasis (pN2 stage III disease) is still unsatisfactory. Both systemic and local recurrence should be prevented after curative surgery. The aim of this study was to explore the pattern of recurrence in patients with completely resected pN2 non-small-cell lung cancer (NSCLC) in the era of adjuvant chemotherapy. METHODS We investigated 337 patients with completely resected cN0-1 and pN2 NSCLC from 2005 to 2016 at National Cancer Center Hospital, Japan. The patterns of recurrence were compared between patients who were managed by observation alone and those with adjuvant chemotherapy. In patients with regional LN recurrence, the pattern and site of recurrence were also explored. RESULTS There were 195 (58.5%) men and 142 (41.5%) women with a mean age of 63.2 years. Fifty-five (16.3%) patients developed only regional LN recurrence, 116 (32.6%) patients developed only distant recurrence and 65 (19.3%) patients developed both regional LN recurrence and distant recurrence. The difference in the pattern of recurrence between patients with observation alone and those with adjuvant chemotherapy was not statistically significant (P = 0.145). As for the pattern of regional LN recurrence, 68 (20.2%) patients had LN recurrence inside the systematic nodal dissection area. CONCLUSIONS Regional LN recurrence was observed in >30% of patients with completely resected pN2 NSCLC. About 20% of patients had recurrence inside the systematic nodal dissection area. Postoperative radiotherapy might be considered as an additional treatment strategy for these patients.

A randomized trial of systematic nodal dissection in resectable non-small cell lung cancer

Lung Cancer ◽  
2002 ◽  
Vol 36 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Yi-long Wu ◽  
Zhi-fan Huang ◽  
Si-yu Wang ◽  
Xue-ning Yang ◽  
Wei Ou
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Randomized Trial ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Nodal Dissection ◽  
Systematic Nodal Dissection

scholarly journals Permissible Outcomes of Lobe-Specific Lymph Node Dissection for Elevated Carcinoembryonic Antigen in Non-Small Cell Lung Cancer

Medicina ◽  
2021 ◽  
Vol 57 (12) ◽  
pp. 1365
Author(s):  
Hiroaki Kuroda ◽  
Junji Ichinose ◽  
Katsuhiro Masago ◽  
Yusuke Takahashi ◽  
Takeo Nakada ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Carcinoembryonic Antigen ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Disease Free Survival ◽  
Small Cell ◽  
Small Cell Lung ◽  
Nodal Dissection ◽  
Nsclc Patients

Background and Objectives: Lobe-specific nodal dissection (L-SND) is currently acceptable for the dissection of early-stage non-small cell lung cancer (NSCLC) but not for cancers of more advanced clinical stages. We aimed to assess the efficacy of L-SND, compared to systemic nodal dissection (SND). Materials and Methods: We retrospectively collected the clinical data of patients with carcinoembryonic antigen (CEA) abnormality who underwent complete resection of NSCLC via lobectomy or more in addition to either SND or L-SND at two cancer-specific institutions from January 2006 to December 2017. Results: A total of 799 patients, including 265 patients who underwent SND and 534 patients who underwent L-SND, were included. On multivariate analysis, thoracotomy, more than lobectomy, cN1-2, advanced pathological stage, adjuvant treatment, and EGFR or ALK were strongly associated with SND. No significant differences were found in overall survival, disease-free survival, and overtime survival after propensity adjustment (p = 0.09, p = 0.11, and p = 0.50, respectively). There were no significant differences in local (p = 0.16), regional (p = 0.72), or distant (p = 0.39) tumor recurrence between the two groups. Conclusions: SND did not improve the prognosis of NSCLC patients with CEA abnormality. Complete pulmonary resection via L-SND seems useful for NSCLC patients with CEA abnormality.

Time Trends of Perioperative Outcomes in Early Stage Non-Small Cell Lung Cancer Resection Patients

2020 ◽  
Vol 109 (2) ◽  
pp. 404-411 ◽  
Author(s):  
Jitesh B. Shewale ◽  
Arlene M. Correa ◽  
Eric L. Brown ◽  
Luis G. Leon-Novelo ◽  
Alan G. Nyitray ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Time Trends ◽  
Early Stage ◽  
Small Cell ◽  
Perioperative Outcomes ◽  
Small Cell Lung ◽  
Cancer Resection

Time trends and predictors of survival in surgically resected early‐stage non–small cell lung cancer patients

2020 ◽  
Vol 122 (3) ◽  
pp. 495-505 ◽  
Author(s):  
Jitesh B. Shewale ◽  
Erin M. Corsini ◽  
Arlene M. Correa ◽  
Eric L. Brown ◽  
Luis G. Leon‐Novelo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Patients ◽  
Cell Lung Cancer ◽  
Time Trends ◽  
Early Stage ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Patients

scholarly journals Surgical Results of Non-small Cell Lung Cancer in Nepal

2014 ◽  
Vol 52 (196) ◽  
pp. 992-996
Author(s):  
Binay Thakur ◽  
Di Yonghui ◽  
Mukti Devekota ◽  
Paribartan Baral ◽  
Bishworam Poudel
Keyword(s):  
Lung Cancer ◽  
Overall Survival ◽  
Pulmonary Resection ◽  
Early Stage ◽  
Small Cell ◽  
R0 Resection ◽  
Surgical Results ◽  
Small Cell Lung ◽  
Diagnosis Of Lung Cancer ◽  
Nsclc Patients

Introduction: Surgery remains the only curative modality for early stage of Non small cell lung caner (NSCLC). We reviewed overall scenario of lung cancer and surgical results in Nepal. Methods: 1000 patients with the pathological diagnosis of lung cancer were analyzed to summarize the overall scenario of lung cancer. 157 NSCLC patients underwent pulmonary resection. cIA, IB, IIA, IIB, IIIA (N1) underwent surgery as initial modality of treatment. cIIIA (N2) patients were taken for surgery after neoadjuvant chemo/ chemoradiation. Results: Analysis of 1000 patients showed squamous cell carcinoma in 41.3%, incurable stage (IIIB/ IV) in 66.8% and rate of curative resection in 6.7% cases. Surgery as a single modality of treatment was used in 38%. Neoadjuvant Chemo/ chemoradiation/ radiation followed by surgery and surgery followed by chemo/ chemoradiation/ radiation was done in 12% and 50%, respectively. In-hospital mortality was 2% (post pneumonectomy: 5.5%; post lobectomy: 1.5%; post sublobar resection: 0%). R0 resction was achieved in 91% cases. Median survival and 5-year overall survival were 36 months and 18%, respectively. Better survival was achieved in pI-II vs pIII/ IV, pN0-1 vs pN2 and pR0 vs pR+ (p <0.05). Conclusions: Earlier stage (pI-II), R0 resection and pathological pNo-1 has the best five year overall survival in Nepalese patients with NSCLC as well.Keywords: lung cancer; NSCLC; pulmonary resection.

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