Mortality risk and pulmonary function in adults with cystic fibrosis at time of wait listing for lung transplantation in the United States

We characterized vulnerable populations located in areas at higher risk of COVID-19-related mortality and low critical healthcare capacity during the early stage of the epidemic in the United States. We analyze data obtained from a Johns Hopkins University COVID-19 database to assess the county-level spatial variation of COVID-19-related mortality risk during the early stage of the epidemic in relation to health determinants and health infrastructure. Overall, we identified highly populated and polluted areas, regional air hub areas, race minorities (non-white population), and Hispanic or Latino population with an increased risk of COVID-19-related death during the first phase of the epidemic. The 10 highest COVID-19 mortality risk areas in highly populated counties had on average a lower proportion of white population (48.0%) and higher proportions of black population (18.7%) and other races (33.3%) compared to the national averages of 83.0%, 9.1%, and 7.9%, respectively. The Hispanic and Latino population proportion was higher in these 10 counties (29.3%, compared to the national average of 9.3%). Counties with major air hubs had a 31% increase in mortality risk compared to counties with no airport connectivity. Sixty-eight percent of the counties with high COVID-19-related mortality risk also had lower critical care capacity than the national average. The disparity in health and environmental risk factors might have exacerbated the COVID-19-related mortality risk in vulnerable groups during the early stage of the epidemic.

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Gender and Racial Disparities in Lung Transplantation in the United States

The Journal of Heart and Lung Transplantation ◽

10.1016/j.healun.2021.06.004 ◽

2021 ◽

Author(s):

Leonard E. Riley ◽

Jorge Lascano

Keyword(s):

United States ◽

Lung Transplantation ◽

Racial Disparities ◽

The United States

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Long-Term Impact of Ivacaftor on Healthcare Resource Utilization Among People with Cystic Fibrosis in the United States

Pulmonary Therapy ◽

10.1007/s41030-021-00154-9 ◽

2021 ◽

Author(s):

Teja Thorat ◽

Lisa J. McGarry ◽

Krutika Jariwala-Parikh ◽

Brendan Limone ◽

Machaon Bonafede ◽

...

Keyword(s):

United States ◽

Cystic Fibrosis ◽

Resource Utilization ◽

Healthcare Resource ◽

The United States ◽

Healthcare Resource Utilization ◽

Long Term Impact

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Mycobacterium talmoniae, a Potential Pulmonary Pathogen Isolated from Multiple Patients with Bronchiectasis in the United States, Including the First Case of Clinical Disease in a Patient with Cystic Fibrosis

Journal of Clinical Microbiology ◽

10.1128/jcm.00906-18 ◽

2018 ◽

Vol 57 (2) ◽

Cited By ~ 1

Author(s):

Ravikiran Vasireddy ◽

Sruthi Vasireddy ◽

Barbara A. Brown-Elliott ◽

Alexander L. Greninger ◽

Rebecca M. Davidson ◽

...

Keyword(s):

United States ◽

Cystic Fibrosis ◽

16S Rrna ◽

Type Strain ◽

Gene Sequencing ◽

The United States ◽

Average Nucleotide Identity ◽

Content Type ◽

First Case ◽

Multiple Patients

ABSTRACTWe characterize three respiratory isolates of the recently described speciesMycobacterium talmoniaerecovered in Texas, Louisiana, and Massachusetts, including the first case of disease in a patient with underlying cystic fibrosis. The three isolates had a 100% match toM. talmoniaeNE-TNMC-100812Tby complete 16S rRNA,rpoBregion V, andhsp65 gene sequencing. Core genomic comparisons between one isolate and the type strain revealed an average nucleotide identity of 99.8%. The isolates were susceptible to clarithromycin, amikacin, and rifabutin, while resistance was observed for tetracyclines, ciprofloxacin, and linezolid.M. talmoniaeshould be added to the list of potential pulmonary pathogens, including in the setting of cystic fibrosis.

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