Impact of respiratory syncytial virus infection and palivizumab on severe acute lower respiratory infection during the first 6 months of life in a cohort of Colombian infants.

Virus Infection ◽

Respiratory Infection ◽

Respiratory Syncytial Virus Infection ◽

Wheeze associated respiratory infection is an important cause of morbidity andmortality in both the developed and the developing worlds. The commonest causativeagent is the Respiratory Syncytial Virus (RSV). Lower respiratory infection with thisvirus is assuming great proportions and hence much work is being done to find a cureor at least a suitable vaccine that will be available to everyone even in the poorercountries. This article reviews the latest literature and attempts to set out someguidelines to help inreduction of the problems associated with lower respiratoryinfection caused by RSV in developing countries.Key Words : Lower respiratory infection, Respiratory Syncytial Virus.

Hospitalization Rate of Respiratory Syncytial Virus associated Acute Lower Respiratory Infection among Young Children in Suzhou, China, 2010-2014

10.22541/au.163871839.90674988/v1 ◽

2021 ◽

Author(s):

Shaolong Ren ◽

Ting Shi ◽

Wei Shan ◽

Si Shen ◽

Qinghui Chen ◽

...

Keyword(s):

Young Children ◽

Respiratory Infection ◽

Disease Burden ◽

Estimation Method ◽

Hospitalization Rate ◽

Treatment Data ◽

Background: Data on disease burden of respiratory syncytial virus (RSV) associated acute lower respiratory infection (ALRI) among young children are limited in China. This study aimed to estimate the hospitalization rate of RSV-associated ALRI (RSV-ALRI) among children aged 0~59 months in Suzhou, China. Methods: We retrospectively identified all hospitalized ALRI children aged 0~59 months in Suzhou University Affiliated Children’s Hospital during January 2010 to December 2014. Detailed diagnosis and treatment data were collected by individual medical chart review. Referring to WHO influenza disease burden estimation method, we estimated the hospitalization rate of RSV-ALRI among children aged 0~59 months in Suzhou, China. Results: Among 28,209 ALRI cases, 19,317 (68.5%) were tested for RSV and the RSV positive proportion was 21.3% (4,107/19,317). The average hospitalization rate of RSV-ALRI for children aged 0~59 months was 14 (95% confidence interval [CI]:14~14)/1,000 children-years, for children aged 0~5, 6~11, 12~23, and 24~59 months were 70 (95%CI: 67~73), 31 (95%CI: 29~33), 11 (95%CI: 10~12), and 3 (95%CI: 3~3) /1,000 children-years, respectively. Conclusion: There is considerable RSV-ALRI hospitalization among children aged 0~59 months, particularly among children aged <1 years. An effective monoclonal antibody or vaccine is urgently needed to address the substantial hospitalization burden owing to RSV infection. Key words: Respiratory syncytial virus, Hospitalization rate, Acute lower respiratory infection, Children, China

Respiratory syncytial virus infection among young children with acute respiratory tract infection in Iraq

Eastern Mediterranean Health Journal ◽

10.26719/1999.5.5.941 ◽

1999 ◽

Vol 5 (5) ◽

pp. 941-948

Author(s):

K. A. Albargish ◽

H. J. Hasony

Keyword(s):

Virus Infection ◽

Respiratory Infection ◽

Respiratory Syncytial Virus Infection ◽

Acute Respiratory Infection ◽

Acute Respiratory Tract Infection ◽

Control Group ◽

Severe Acute Respiratory Infection ◽

Syncytial Virus ◽

Children Under 5

The incidence of respiratory syncytial virus infection was assessed among 516 children under 5 years with acute respiratory infection and 57 control children free of respiratory infection to determine its relation to epidemiological variables. Respiratory syncytial virus was detected in 188 [37.6%]children with acute respiratory infection and in none of the control group. The infection was highest in those with severe acute respiratory infection, particularly severe bronchiolitis and pneumonia and it precipitated acute bronchial asthma in children over 2 years. The infection was most common in the first 6 months and both sexes were equally affected. Socioeconomic factors and crowding played no significant role in the incidence and spread of the infection. Breastfeeding had no clear protective effect against the infection

Hospitalization rate of respiratory syncytial virus‐associated acute lower respiratory infection among young children in Suzhou, China, 2010–2014

Influenza and Other Respiratory Viruses ◽

10.1111/irv.12958 ◽

2022 ◽

Author(s):

Shaolong Ren ◽

Ting Shi ◽

Wei Shan ◽

Si Shen ◽

Qinghui Chen ◽

...

Keyword(s):

Young Children ◽

Respiratory Infection ◽

Hospitalization Rate ◽

Severe respiratory disease caused by human respiratory syncytial virus impairs language learning during early infancy

Scientific Reports ◽

10.1038/s41598-020-79140-1 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Marcela Peña ◽

Cristina Jara ◽

Juan C. Flores ◽

Rodrigo Hoyos-Bachiloglu ◽

Carolina Iturriaga ◽

...

Keyword(s):

Virus Infection ◽

Language Learning ◽

Respiratory Infection ◽

Respiratory Syncytial Virus Infection ◽

Learning Difficulties ◽

Human Respiratory Syncytial Virus ◽

Severe Respiratory Infection ◽

AbstractHuman respiratory syncytial virus infection is a leading cause of pediatric morbidity and mortality. A previous murine study showed that during severe acute respiratory infections the virus invades the central nervous system, and that infected animals evolve with long-lasting learning difficulties associated with long-term potentiation impairment in their hippocampus. We hypothesized here that human infants who presented a severe episode of respiratory syncytial virus infection before 6 months of age would develop long-term learning difficulties. We measured the acquisition of the native phoneme repertoire during the first year, a milestone in early human development, comprising a reduction in the sensitivity to the irrelevant nonnative phonetic information and an increase in the sensitivity to the information relevant for the native one. We found that infants with a history of severe respiratory infection by the human respiratory syncytial virus presented poor distinction of native and nonnative phonetic contrasts at 6 months of age, and remained atypically sensitive to nonnative contrasts at 12 months, which associated with weak communicative abilities. Our results uncover previously unknown long-term language learning difficulties associated with a single episode of severe respiratory infection by the human respiratory syncytial virus, which could relate to memory impairments.

Epidemiology, clinical characteristics, laboratory findings and severity of respiratory syncytial virus acute lower respiratory infection in Malaysian children, 2008-2013

Journal of Paediatrics and Child Health ◽

10.1111/jpc.13375 ◽

2016 ◽

Vol 53 (4) ◽

pp. 399-407 ◽

Cited By ~ 6

Author(s):

Khuen F Ng ◽

Kah K Tan ◽

Zhi H Sam ◽

Grace SS Ting ◽

Wan Y Gan

Keyword(s):

Respiratory Infection ◽

Clinical Characteristics ◽

Laboratory Findings ◽

Cost of Respiratory Syncytial Virus-Associated Acute Lower Respiratory Infection Management in Young Children at the Regional and Global Level: A Systematic Review and Meta-Analysis

The Journal of Infectious Diseases ◽

10.1093/infdis/jiz683 ◽

2020 ◽

Vol 222 (Supplement_7) ◽

pp. S680-S687 ◽

Cited By ~ 3

Author(s):

Shanshan Zhang ◽

Lily Zainal Akmar ◽

Freddie Bailey ◽

Barbara A Rath ◽

Maren Alchikh ◽

...

Keyword(s):

Young Children ◽

Respiratory Infection ◽

Meta Analysis ◽

Initial Event ◽

Global Cost ◽

Abstract Background Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory infection (ALRI) in young children aged <5 years. Methods We aimed to identify the global inpatient and outpatient cost of management of RSV-ALRI in young children to assist health policy makers in making decisions related to resource allocation for interventions to reduce severe morbidity and mortality from RSV in this age group. We searched 3 electronic databases including Global Health, Medline, and EMBASE for studies reporting cost data on RSV management in children under 60 months from 2000 to 2017. Unpublished data on the management cost of RSV episodes were collected through collaboration with an international working group (RSV GEN) and claim databases. Results We identified 41 studies reporting data from year 1987 to 2017, mainly from Europe, North America, and Australia, covering the management of a total of 365 828 RSV disease episodes. The average cost per episode was €3452 (95% confidence interval [CI], 3265–3639) and €299 (95% CI, 295–303) for inpatient and outpatient management without follow-up, and it increased to €8591(95% CI, 8489–8692) and €2191 (95% CI, 2190–2192), respectively, with follow-up to 2 years after the initial event. Conclusions Known risk factors (early and late preterm birth, congenital heart disease, chronic lung disease, intensive care unit admission, and ventilator use) were associated with €4160 (95% CI, 3237–5082) increased cost of hospitalization. The global cost of inpatient and outpatient RSV ALRI management in young children in 2017 was estimated to be approximately €4.82 billion (95% CI, 3.47–7.93), 65% of these in developing countries and 55% of global costs accounted for by hospitalization. We have demonstrated that RSV imposed a substantial economic burden on health systems, governments, and the society.