Mortality in preterm infants with bronchopulmonary dysplasia associated pulmonary hypertension: a systematic literature review

2020 ◽  
Author(s):  
Laura Downham ◽  
Sofija Cerovic ◽  
Catherine Lesage ◽  
Sandrine Leroy
Keyword(s):  
Pulmonary Hypertension ◽  
Literature Review ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Systematic Literature Review

scholarly journals Targeting Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension (BPD-PH): Potential Role of the FGF Signaling Pathway in the Development of the Pulmonary Vascular System

Cells ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 1875
Author(s):  
Cho-Ming Chao ◽  
Lei Chong ◽  
Xuran Chu ◽  
Amit Shrestha ◽  
Judith Behnke ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Signaling Pathway ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Potential Role ◽  
Vascular System ◽  
Point Of View ◽  
Pulmonary Vasculature ◽  
Curative Therapy

More than 50 years after the first description of Bronchopulmonary dysplasia (BPD) by Northway, this chronic lung disease affecting many preterm infants is still poorly understood. Additonally, approximately 40% of preterm infants suffering from severe BPD also suffer from Bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH), leading to a significant increase in total morbidity and mortality. Until today, there is no curative therapy for both BPD and BPD-PH available. It has become increasingly evident that growth factors are playing a central role in normal and pathologic development of the pulmonary vasculature. Thus, this review aims to summarize the recent evidence in our understanding of BPD-PH from a basic scientific point of view, focusing on the potential role of Fibroblast Growth Factor (FGF)/FGF10 signaling pathway contributing to disease development, progression and resolution.

scholarly journals Pulmonary hypertension associated with bronchopulmonary dysplasia in preterm infants

2017 ◽  
Vol 124 ◽  
pp. 21-29 ◽  
Author(s):  
Christine B. Bui ◽  
Merrin A. Pang ◽  
Arvind Sehgal ◽  
Christiane Theda ◽  
Jason C. Lao ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia

Pulmonary Hypertension in Preterm Infants: Prevalence and Association with Bronchopulmonary Dysplasia

2014 ◽  
Vol 165 (5) ◽  
pp. 909-914.e1 ◽  
Author(s):  
Hussnain Mirza ◽  
James Ziegler ◽  
Sara Ford ◽  
James Padbury ◽  
Richard Tucker ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia

scholarly journals Pulmonary Hypertension in Preterm Infants with Bronchopulmonary Dysplasia

2014 ◽  
Vol 27 (1) ◽  
pp. 8-16 ◽  
Author(s):  
Christopher D. Baker ◽  
Steven H. Abman ◽  
Peter M. Mourani
Keyword(s):  
Pulmonary Hypertension ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia

scholarly journals Clinical and functional features of the small circle of blood circulation in children with a new form of bronchopulmonary dysplasia

2021 ◽  
Vol 24 (5) ◽  
pp. 292-299
Author(s):  
Milana A. Basargina ◽  
Andrey P. Fisenko ◽  
Irina V. Davydova ◽  
Maksim V. Kondratyev ◽  
Anastasiya S. Petrova ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Group Discussion ◽  
Right Heart ◽  
Functional Features ◽  
Reliable Marker ◽  
The Right ◽  
Gestational Age At Birth ◽  
Age At Birth

The aim of the work is to analyze the data of Echo-CG examination of premature infants who have formed and have not formed bronchopulmonary dysplasia (BPD) to determine the frequency of the formation of pulmonary hypertension (PH). Materials and methods. A total of 199 preterm infants treated in the Department of Pathology of Newborns were examined. The first group included moderate and severe BPD children (n = 117; 59%). The second group consisted of children without BPD within clearly decreed terms (n = 82; 41%). In each group, patients were divided into four subgroups by the gestational age at birth and the timing of the Echo-CG. Results. Only two (1.1%) patients out of 117 BPD children of the first group were diagnosed with pulmonary hypertension (PH). In 3 (2.5%) of 117 infants of the same group, enlargement of the right heart without PH was revealed. Out of 82 children without BPD, two patients had signs of right heart enlargement. PH was not diagnosed in any of the patients in this group. Discussion. To aggravate the efficiency of PH diagnosis, a number of indices of screening echocardiography seem to be increased by additional analysis of changes in the systolic eccentricity index (EI), as a reliable marker of PH in BPD children. Systolic IE should be integrated into screening in preterm infants for the diagnosis of PH. The use of Echo-CG data along with analysis of blood BNP or NT-proBNP blood content be also expanded. Optimizing the diagnosis of PH at the early stages of BPD is necessary to increase the efficacy of targeted therapy and reduce the risk of severe complications of BPD.

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