Transcriptome signatures of tobacco carcinogens hint the alteration of TAF6 as a specific feature in smokers lung cancer

2020 ◽  
Author(s):  
M Pepe ◽  
A Lamort ◽  
G Stathopoulos
Keyword(s):  
Lung Cancer ◽  
Tobacco Carcinogens

scholarly journals Multiple Molecular Targets Associated with Genomic Instability in Lung Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Giovanny Soca-Chafre ◽  
Angelica Montiel-Dávalos ◽  
Inti Alberto De La Rosa-Velázquez ◽  
Claudia Haydeé Saraí Caro-Sánchez ◽  
Adriana Peña-Nieves ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Genomic Instability ◽  
Targeted Therapies ◽  
Molecular Mechanisms ◽  
Cell Cycle Control ◽  
Point Mutations ◽  
Number Variation ◽  
Never Smokers ◽  
Diagnosis Therapy ◽  
Tobacco Carcinogens

Lung cancer (LC) is the first cause of cancer-related deaths worldwide. Elucidating the pathogenesis of LC will give information on key elements of tumor initiation and development while helping to design novel targeted therapies. LC is an heterogeneous disease that has the second highest mutation rate surpassed only by melanoma, since 90% of LC occurs in tobacco smokers. However, only a small percent of smokers develops LC, indicating an inherent genomic instability. Additionally, LC in never smokers suggests other molecular mechanisms not causally linked to tobacco carcinogens. This review presents a current outlook of the connection between LC and genomic instability at the molecular and clinical level summarizing its implications for diagnosis, therapy, and prognosis. The genomic landscape of LC shows widespread alterations such as DNA methylation, point mutations, copy number variation, chromosomal translocations, and aneuploidy. Genome maintenance mechanisms including cell cycle control, DNA repair, and mitotic checkpoints open a window to translational research for finding novel diagnostic biomarkers and targeted therapies in LC.

scholarly journals Does the Consumption of Green Tea Reduce the Risk of Lung Cancer among Smokers?

2007 ◽  
Vol 4 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Wenbin Liang ◽  
Colin W. Binns ◽  
Le Jian ◽  
Andy H. Lee
Keyword(s):  
Lung Cancer ◽  
Green Tea ◽  
Experimental Studies ◽  
Epidemiological Studies ◽  
High Level ◽  
Keywords Lung Cancer ◽  
Tobacco Carcinogens ◽  
Regular Intake

Experimental and epidemiological studies were reviewed to assess whether the consumption of green tea could reduce the risk of lung cancer in smokers. Articles published since 1990 were located by searching electronic databases PubMed, Ovid and Science Direct, using keywords ‘lung cancer’, ‘tea’ and ‘smoking’ without any restriction on language. After relevant articles had been located, further papers were obtained from their reference lists. Evidence from experimental studies (in vitroanimal and human trials) suggested that regular intake of green tea may be protective against tobacco carcinogens. However, the mechanism behind the protective effect is only partly understood. In most of the epidemiological studies reviewed, the green tea exposure was within 5 years of the interview or follow-up, which would coincide with the induction period and latent period of lung cancer. Longer term studies are thus needed to further quantify the cancer risk. There is some evidence suggesting regular intake of green tea at high level (>3 cups per day) may reduce the risk of smokers developing lung cancer. Improvement in measuring green tea intake is required in order to confirm the evidence from epidemiological studies.

scholarly journals ED01.02 Tobacco Carcinogens and Lung Cancer Susceptibility

2017 ◽  
Vol 12 (1) ◽  
pp. S19-S20 ◽  
Author(s):  
Stephen Hecht ◽  
S. Lani Park ◽  
Steven Carmella ◽  
Daniel Stram ◽  
Christopher Haiman ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Susceptibility ◽  
Tobacco Carcinogens ◽  
Lung Cancer Susceptibility
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