scholarly journals Evaluation of extra capsular lymph node involvement in patients with extra-hepatic bile duct cancer

2012 ◽  
Vol 10 (1) ◽  
Author(s):  
Takehiro Noji ◽  
Masaki Miyamoto ◽  
Kanako C Kubota ◽  
Toshiya Shinohara ◽  
Yoshiyasu Ambo ◽  
...  
Keyword(s):  
Lymph Node ◽  
Bile Duct ◽  
Bile Duct Cancer ◽  
Lymph Node Involvement ◽  
Hepatic Bile ◽  
Hepatic Bile Duct ◽  
Node Involvement ◽  
Duct Cancer

Prognostic significance of lymph node involvement in middle and distal bile duct cancer

Surgery ◽  
2001 ◽  
Vol 129 (6) ◽  
pp. 677-683 ◽  
Author(s):  
Ryoko Sasaki ◽  
Masahiro Takahashi ◽  
Osamu Funato ◽  
Hiroyuki Nitta ◽  
Masahiko Murakami ◽  
...  
Keyword(s):  
Lymph Node ◽  
Bile Duct ◽  
Bile Duct Cancer ◽  
Prognostic Significance ◽  
Lymph Node Involvement ◽  
Distal Bile Duct ◽  
Node Involvement ◽  
Duct Cancer

Prognostic Factors after Pancreatoduodenectomy for Distal Bile Duct Cancer

2011 ◽  
Vol 77 (11) ◽  
pp. 1445-1448 ◽  
Author(s):  
Qi-Lu Qiao ◽  
Tai-Ping Zhang ◽  
Jun-Chao Guo ◽  
Han-Xiang Zhan ◽  
Jian-Xun Zhao ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Bile Duct ◽  
Bile Duct Cancer ◽  
Lymph Node Involvement ◽  
Distal Bile Duct ◽  
Term Survival ◽  
Distal Cholangiocarcinoma ◽  
Node Involvement ◽  
Duct Cancer

Prognostic factors influencing long-term survival after radical resection for distal bile duct cancer have not been well established because of the rarity of this malignancy. The goal of this study was to identify main prognostic factors in patients undergoing pancreatoduodenectomy for distal bile duct carcinoma. A retrospective study consisting of 122 patients with distal bile duct cancer who underwent pancreatoduodenectomy in three major university hospitals was performed to identify the main prognostic factors. Major surgical complications occurred in 40 patients (32.8%), of whom eight died (6.6%) in the hospital. Overall actuarial survival (excluding hospital deaths) at 1-, 3-, and 5-year follow-up was 82.9, 49.4, and 32.7 per cent, respectively, with a median survival of 36 months. Univariate analysis showed that papillary tumor ( P = 0.045), negative surgical margin (R0 resection, P = 0.005), earlier pT ( P = 0.005), pTNM stage ( P < 0.001), and absence of lymph node involvement ( P < 0.0001) were significant predictors of survival. On multivariate analysis, only lymph node metastasis was shown to be an independent prognostic factor of survival ( P = 0.036). Lymph node involvement was the most important survival predictor after a Whipple resection in patients with distal cholangiocarcinoma.

scholarly journals Clinical study on surgical patients with hepatic bile duct cancer.

1989 ◽  
Vol 22 (8) ◽  
pp. 2099-2101
Author(s):  
Masaaki MATSUZAKI ◽  
Masaharu MURASE ◽  
Kaoru AKAZA ◽  
Shizuka HORIO ◽  
Harumi SAKUMA
Keyword(s):  
Clinical Study ◽  
Bile Duct ◽  
Bile Duct Cancer ◽  
Surgical Patients ◽  
Hepatic Bile ◽  
Hepatic Bile Duct ◽  
Duct Cancer

scholarly journals Postoperative radiotherapy dose correlates with locoregional control in patients with extra-hepatic bile duct cancer

2014 ◽  
Vol 32 (1) ◽  
pp. 7 ◽  
Author(s):  
Jung Ho Im ◽  
Jinsil Seong ◽  
Jeongshim Lee ◽  
Yong Bae Kim ◽  
Ik Jae Lee ◽  
...  
Keyword(s):  
Bile Duct ◽  
Bile Duct Cancer ◽  
Postoperative Radiotherapy ◽  
Locoregional Control ◽  
Hepatic Bile ◽  
Hepatic Bile Duct ◽  
Duct Cancer ◽  
Radiotherapy Dose

scholarly journals Is combined extra-hepatic bile-duct resection justified for advanced gallbladder carcinoma?

2019 ◽  
Vol 7 (6) ◽  
pp. 426-433 ◽  
Author(s):  
Jun-Ke Wang ◽  
Wen-Jie Ma ◽  
Zhen-Ru Wu ◽  
Qin Yang ◽  
Hai-Jie Hu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Bile Duct ◽  
Lymph Node Metastasis ◽  
Gallbladder Carcinoma ◽  
Curative Surgery ◽  
Hepatic Bile ◽  
Hepatic Bile Duct ◽  
Resection Group ◽  
Node Metastasis ◽  
T Category

Abstract Background Whether the extra-hepatic bile duct (EHBD) should be routinely resected for gallbladder carcinoma (GBC) remains controversial. The current study aimed to determine the clinical impact of combined EHBD resection during curative surgery for advanced GBC. Methods In total, 213 patients who underwent curative surgery for T2, T3 or T4 GBC were enrolled. The clinicopathological features were compared between the patients treated with EHBD resection and those without EHBD resection. Meanwhile, univariable and multivariable Cox-proportional hazards regression models were used to identify risk factors for overall survival (OS). Results Among the 213 patients identified, 87 (40.8%) underwent combined EHBD resection. Compared with patients without EHBD resection, patients with EHBD resection suffered more post-operative complications (33.3% vs. 21.4%, P = 0.046). However, the median OS of the EHBD resection group was longer than that of the non-EHBD resection group (25 vs. 11 months, P = 0.008). Subgroup analyses were also performed according to tumor (T) category and lymph-node metastasis. The median OS was significantly longer in the EHBD resection group than in the non-EHBD resection group for patients with T3 lesion (15 vs. 7 months, P = 0.002), T4 lesion (11 vs. 6 months, P = 0.021) or lymph-node metastasis (12 vs. 7 months, P &lt; 0.001). No survival benefit of EHBD resection was observed in GBC patients with T2 lesion or without lymph-node metastasis. T category, lymph-node metastasis, margin status, pre-operative CA19-9 level and EHBD resection were identified as independent prognostic factors for OS of patients with advanced GBC (all P values &lt;0.05). Conclusions EHBD resection can independently affect the OS in advanced GBC. For GBC patients with T3 lesion, T4 lesion and lymph-node metastasis, combined EHBD resection is justified and may improve OS.

Adequate lymph node assessment for extrahepatic bile duct cancer: Do the data support the current AJCC recommendations?

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 4576-4576
Author(s):  
K. Ito ◽  
H. Ito ◽  
M. Gonen ◽  
P. J. Allen ◽  
M. I. D’Angelica ◽  
...  
Keyword(s):  
Lymph Node ◽  
Bile Duct ◽  
Bile Duct Cancer ◽  
Extrahepatic Bile Duct ◽  
Lymph Node Status ◽  
Pathology Report ◽  
Extrahepatic Bile Duct Cancer ◽  
Significant Difference ◽  
N Stage ◽  
Duct Cancer

4576 Background: AJCC staging manual 6th edition states that histologic examination of at least 3 lymph nodes (LN) is required for adequate N stage determination for extrahepatic bile duct cancer (EHBDCA). We hypothesize that this recommendation is insufficient and will lead to underestimation of N stage of EHBDCA. Methods: 257 patients (144 hilar [HCCA] and 113 distal [DCA] cholangiocarcinoma) who underwent curative intent resection for EHBDCA at our institution (1993 -2007) were analyzed. Final disease staging, including lymph node status and total number of nodes examined, was obtained from the pathology report. Differences in disease specific survival (DSS), according to nodal status, were compared using log rank test. R1 resections (n=51) were excluded from this analysis. Results: There were 89 patients (34.6%) with LN metastasis. On multivariate analysis, LN metastasis was an independent prognostic factor of poor survival (median DSS N0 vs N1: 53.3 months vs 19.3 months, p<0.0001, HR= 2.2 [95%CI: 1.5 - 3.2]). Median total LN count (TLNC) was 6 (range: 0 - 42). There was a significant difference in TLNC between HCCA and DCA (median = 3 [range: 0 - 16] vs 12 [range: 1 - 42], p<0.001, respectively). Among patients who underwent R0 resection for EHBDCA, “N0” based on TLNC < 11 was associated with worse DSS than “N0” based on TLNC > 11. When analyzed separately, “N0” based on TLNC < 7 for HCCA and < 11 for DCA revealed poorer DSS than “N0” based on greater TLNC ( Table ). Conclusions: The recommendation for LN assessment of EHBDCA by AJCC 6th Edition (“at least 3”) could lead the underestimation of N stage. HCCA and DCA should have separate recommendations for adequate LN assessment. [Table: see text] No significant financial relationships to disclose.

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