scholarly journals Can we put a simplified algorithm for reconstruction of large scalp defects following tumor resection?

2011 ◽  
Vol 9 (1) ◽  
Author(s):  
Adel Denewer ◽  
Ashraf Khater ◽  
Omar Farouk ◽  
Mohammad Hegazy ◽  
Mahmoud Mosbah ◽  
...  
Keyword(s):  
Tumor Resection ◽  
Scalp Defects ◽  
Simplified Algorithm

Giant Eccrine Adenocarcinoma of the Scalp with Intracranial Invasion:Resection and Reconstruction Using a Vacuum-assisted Closure Device:Technical Case Report

2006 ◽  
Vol 58 (suppl_4) ◽  
pp. ONS-E371-ONS-E371 ◽  
Author(s):  
Daniel J. Donovan ◽  
Donald A. Person
Keyword(s):  
Wound Closure ◽  
Tumor Resection ◽  
Muscle Flap ◽  
Cerebrospinal Fluid Leakage ◽  
Split Thickness Skin Graft ◽  
Closure Device ◽  
Soft Tissue Coverage ◽  
Neurosurgical Procedures ◽  
Secondary Intention ◽  
Scalp Defects

Abstract Objective and Importance: Carcinoma of the adnexal structures of the skin is a rare malignancy, and is even more unusual in the scalp. We report an unusual case of scalp adnexal carcinoma of eccrine origin that went untreated for years, resulting in a giant tumor with extension through the cranium. The tumor resection and reconstruction of the cranium and scalp defects posed unique challenges. Clinical Presentation: A 54-year-old woman experienced a large recurrence of her scalp adnexal carcinoma after an incomplete wide local excision, which invaded through the cranium. Intervention: The entire vertex of the scalp and cranium were removed en bloc. After cranioplasty, a free vascularized muscle flap was used for soft tissue coverage, but failed owing to poor vascular inflow. A large area of dura was left open, using a vacuum-assisted wound closure device to generate granulation tissue by secondary intention. Another split thickness skin graft was used to provide a cosmetically acceptable outcome. Conclusion: Scalp adnexal tumors of eccrine origin rarely metastasize and can be resected for cure with complete removal. Reconstruction options for large scalp and cranial tumors may be limited, and allowing the dura to granulate by secondary intention has been very rarely described. The novel use of a vacuum-assisted wound closure device was a very useful adjunct in this situation, and may be beneficial in the reconstruction of other patients with large scalp and cranial defects after neurosurgical procedures. It should be used with caution, since it may risk injury to a major venous sinus, especially when used in the midline, or cerebrospinal fluid leakage.

Reconstruction Scalp Defects After Malignant Tumor Resection With Anterolateral Thigh Flaps

2011 ◽  
Vol 22 (6) ◽  
pp. 2208-2211 ◽  
Author(s):  
Bi Bo ◽  
Yang Qun ◽  
Pu Zheming ◽  
Xiao Haitao ◽  
Liu Tianyi
Keyword(s):  
Malignant Tumor ◽  
Tumor Resection ◽  
Scalp Defects ◽  
Anterolateral Thigh ◽  
Anterolateral Thigh Flaps

scholarly journals Use of the O-Z Flap to Repair Scalp Defects After Cancer Tumor Resection

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jian Lin ◽  
Peng Wei ◽  
Yi Xu ◽  
Guoyao Wang ◽  
Kerong Wu ◽  
...  
Keyword(s):  
Tumor Resection ◽  
Scalp Defects ◽  
Cancer Tumor ◽  
After Cancer

scholarly journals Scalp Reconstruction after Malignant Tumor Resection: An Analysis and Algorithm

2019 ◽  
Vol 81 (02) ◽  
pp. 149-157
Author(s):  
Denis Ehrl ◽  
Alexandra Brueggemann ◽  
P. Niclas Broer ◽  
Konstantin Koban ◽  
Riccardo Giunta ◽  
...  
Keyword(s):  
Average Length ◽  
Donor Site ◽  
Tumor Resection ◽  
Donor Site Morbidity ◽  
Muscle Flaps ◽  
Scalp Defects ◽  
Oncologic Patients ◽  
Deep Infiltration ◽  
Malignant Skin ◽  
Aesthetic Results

Abstract Background An oncologic tumor resection of the scalp can result in complex wounds that result in challenging scalp reconstructions. This study aimed to evaluate the outcomes of microvascular-based scalp reconstructions (MSR) in oncologic patients and to propose an algorithmic treatment approach. Methods Within a 5-year period, 38 patients having undergone 41 MSR (15 anterolateral thigh (ALT), 15 gracilis muscle (GM), and 11 latissimus dorsi muscle (LDM) flaps) after extensive scalp tumor resections fulfilled inclusion criteria for this study. Results Malignant skin disease included superficial and/or deep infiltration of the calvarium in 26 and combined intracranial infiltration in 12 patients. In case of bone replacement (24 patients), MSR was done concomitant, otherwise MSR was performed after pathological confirmation of tumor-free margins. LDM flaps were used in cases with defect sizes of 400 to 1250cm2, whereas ALT- and GM flaps were chosen for defects ranging from 40 to 350cm2. The average length of the pedicle was comparable in ALT- and LDM flaps and longer than in GM flaps. Total flap loss with need for revision surgery and minor donor site morbidity occurred in four and three patients, respectively. Conclusion Microsurgical reconstruction of moderate-to-extensive scalp defects remains a reliable method with overall low risks and satisfactory aesthetic results, while, according to our experience, muscle flaps show the best functional and aesthetic results. However, in cases of central scalp defects and in situations when a long vascular pedicle of the flap is important, the ALT flap seems to be the best solution.

Decellularized bone extracellular matrix in skeletal tissue engineering

2020 ◽  
Vol 48 (3) ◽  
pp. 755-764
Author(s):  
Benjamin B. Rothrauff ◽  
Rocky S. Tuan
Keyword(s):  
Tissue Engineering ◽  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Animal Studies ◽  
Tumor Resection ◽  
Regenerative Capacity ◽  
Skeletal Tissue ◽  
Large Bone

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmacological). At present, autografts and allografts are the principal biological treatments available to replace large bone segments, but both entail several limitations that reduce wider use and consistent success. The use of decellularized extracellular matrices (ECM), often derived from xenogeneic sources, has been shown to favorably influence the immune response to injury and promote site-appropriate tissue regeneration. Decellularized bone ECM (dbECM), utilized in several forms — whole organ, particles, hydrogels — has shown promise in both in vitro and in vivo animal studies to promote osteogenic differentiation of stem/progenitor cells and enhance bone regeneration. However, dbECM has yet to be investigated in clinical studies, which are needed to determine the relative efficacy of this emerging biomaterial as compared with established treatments. This mini-review highlights the recent exploration of dbECM as a biomaterial for skeletal tissue engineering and considers modifications on its future use to more consistently promote bone regeneration.

Lung Tumor Resection Ups Melanoma Survival

2007 ◽  
Vol 38 (7) ◽  
pp. 46
Author(s):  
ALICIA AULT
Keyword(s):  
Lung Tumor ◽  
Tumor Resection

Abstract #95: Diabetes Mellitus Remission after Multiple Tumor Resection in Pheochromocytoma

2004 ◽  
Vol 10 ◽  
pp. 33
Author(s):  
Simona Fica ◽  
Ana Maria Stefanescu ◽  
Carmen Barbu ◽  
Dana Terzea ◽  
M. Coculescu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Tumor Resection ◽  
Multiple Tumor

Die Anämie bei malignen Tumorerkrankungen

1989 ◽  
Vol 28 (06) ◽  
pp. 247-254
Author(s):  
E. Aulbert
Keyword(s):  
Malignant Tumors ◽  
Gradient Centrifugation ◽  
Tumor Resection ◽  
Hemoglobin Concentration ◽  
Limiting Factor ◽  
Novikoff Hepatoma ◽  
Tumor Mass ◽  
Lysosomal Fraction ◽  
Proliferation Activity ◽  
Morris Hepatoma

The cellular uptake and lysosomal accumulation of 67Ga-labelled transferrin within tumors of different malignancy were examined using tissue fractionation and immunological techniques. As tumor models the slowly growing Morris hepatoma 5123C, the moderately growing Novikoff hepatoma and the fast and aggressive Yoshida hepatoma AH 130 were investigated. Isolation of subcellular fractions of tumor homogenates was performed by differential centrifugation and density-gradient centrifugation. The intracellular 67Gatransferrin was found to be highly concentrated within the purified lysosomes. The transferrin within the lysosomal fraction was identified by radial immunodiffusion technique using monospecific antiserum. The accumulation of 67Gatransferrin by the tumors resulted in a faster disappearance of 67Ga-transferrin from the blood. This loss of circulating 67Ga-transferrin correlated with the proliferation activity and the spread of the tumors. Since transferrin is indispensible for the utilization of iron by the heme-synthesizing red cell precursors, transferrin concentration in the blood is the limiting factor for the utilization of iron in hemoglobin synthesis. Thus, in a further series of experiments we investigated the development of anemia in tumor-bearing rats. With increasing tumor mass a progressive fall of hemoglobin concentration was found. The anemia was more severe in the faster growing Novikoff hepatoma than in the slowly growing Morris hepatoma. The most significant reduction of hemoglobin concentration was found in the very fast growing Yoshida hepatoma. After total tumor resection hemoglobin concentration and red blood cell count normalized completely within 6-8 weeks. We conclude from these data that the uptake of transferrin by the tumor cells results in a faster disappearance of transferrin from the blood. This loss of circulating transferrin correlates with tumor mass and proliferation activity and is one of the factors responsible for the anemia seen in patients with malignant tumors.

Sign in / Sign up

Export Citation Format

Share Document