Gadolinium enhanced magnetic resonance mean voxel signal intensity within the left ventricular myocardium changes prior to ejection fraction drop after receipt of cardiotoxic chemotherapy

Background: Proton beam therapy offers radiophysical properties that are appealing for noninvasive arrhythmia elimination. This study was conducted to use scanned proton beams for ablation of cardiac tissue, investigate electrophysiological outcomes, and characterize the process of lesion formation in a porcine model using particle therapy. Methods: Twenty-five animals received scanned proton beam irradiation. ECG-gated computed tomography scans were acquired at end-expiration breath hold. Structures (atrioventricular junction or left ventricular myocardium) and organs at risk were contoured. Doses of 30, 40, and 55 Gy were delivered during expiration to the atrioventricular junction (n=5) and left ventricular myocardium (n=20) of intact animals. Results: In this study, procedural success was tracked by pacemaker interrogation in the atrioventricular junction group, time-course magnetic resonance imaging in the left ventricular group, and correlation of lesion outcomes displayed in gross and microscopic pathology. Protein extraction (active caspase-3) was performed to investigate tissue apoptosis. Doses of 40 and 55 Gy caused slowing and interruption of cardiac impulse propagation at the atrioventricular junction. In 40 left ventricular irradiated targets, all lesions were identified on magnetic resonance after 12 weeks, being consistent with outcomes from gross pathology. In the majority of cases, lesion size plateaued between 12 and 16 weeks. Active caspase-3 was seen in lesions 12 and 16 weeks after irradiation but not after 20 weeks. Conclusions: Scanned proton beams can be used as a tool for catheter-free ablation, and time-course of tissue apoptosis was consistent with lesion maturation.

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Changes of Cardiac Magnetic Resonance T1 and ECV Values in Healthy Adults of Different Gender and Age

10.21203/rs.3.rs-863090/v1 ◽

2021 ◽

Author(s):

Shumei Huang ◽

Meng Zhang ◽

Kanghui Yu ◽

Xiaofen Ma ◽

Chunlong Li ◽

...

Keyword(s):

Cardiac Magnetic Resonance ◽

Magnetic Resonance ◽

T1 Mapping ◽

Healthy Adult ◽

Extracellular Volume ◽

Ventricular Myocardium ◽

Left Ventricular ◽

Healthy Adults ◽

Left Ventricular Myocardium ◽

3T Mri

Abstract BackgroundThe correlation between T1 and ECV value and myocardial fibrosis has been confirmed. In healthy adult, many disease may change T1 and ECV value. The purpose of this reseach is to clarify the T1 mapping and extracellular volume (ECV) value of healthy adults in 3 Tesla (T) magnetic resonance imaging (MRI), and to study the relationship between the values with age and gender.MethodsWe recruited 87 healthy adult subjects (mean age 38 ± 11 years; 61% were females) for cardiac magnetic resonance examination at 3T MRI. The left ventricular function parameters were obtained from functional imaging. T1 mapping was performed using an improved Look-Locker reversal recovery sequence after motion correction. ResultsUnder 3T field strength, T1 value of the myocardium of healthy adults was 1,261 ± 52, and the ECV value was 28.3% ± 2.9%. T1 value and ECV values of female myocardium were higher than those of males (1,274 ± 56 vs. 1,241 ± 40, P = 0.003; 29.6% ± 2.6% vs. 26.2% ± 2.1%, P < 0.001). Only gender (Beta = 0.311, P = 0.003) was independently related to the native T1 mapping of left ventricular myocardium, while gender (Beta = 0.572, P < 0.001) and age (Beta = 0.501, P = 0.003) were related to the ECV value of left ventricular myocardium. T1 value (P = 0.002) and ECV value (P = 0.013) increased significantly from the base to the apex. There were significant differences in the T1 and ECV value between each segment (P < 0.001) in the base of the left ventricle. Significant differences were observed between the middle segments of T1 value (P = 0.001) but not between the middle of the ECV value of each segment (P = 0.068). Lastly, there was no statistical difference between each segment in the apical of the T1 (P = 0.756) and ECV value (P = 0.344).ConclusionsUnder 3T MRI, the T1 value of the myocardium of healthy adults was 1,261 ± 52, and the ECV value was 28.3% ± 2.9%. T1 and ECV values of females were significantly higher than those of males. The ECV values of males increased with age, while T1 value in males and T1 and ECV values in females had no significant relationship with age.

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Magnetic resonance imaging of targeted catheter-based implantation of myogenic precursor cells into infarcted left ventricular myocardium

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(03)00414-5 ◽

2003 ◽

Vol 41 (10) ◽

pp. 1841-1846 ◽

Cited By ~ 63

Author(s):

J.érôme Garot ◽

Thierry Unterseeh ◽

Emmanuel Teiger ◽

S.téphane Champagne ◽

B.énédicte Chazaud ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Ventricular Myocardium ◽

Left Ventricular ◽

Precursor Cells ◽

Left Ventricular Myocardium ◽

Resonance Imaging ◽

Myogenic Precursor

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Changes of Cardiac Magnetic Resonance T1 and ECV Values in Healthy Adults of Different Gender and Age

10.21203/rs.3.rs-863090/v2 ◽

2021 ◽

Author(s):

Shumei Huang ◽

Meng Zhang ◽

Kanghui Yu ◽

Chunlong Li ◽

Zhihong Lan ◽

...

Keyword(s):

Cardiac Magnetic Resonance ◽

Magnetic Resonance ◽

T1 Mapping ◽

Healthy Adult ◽

Extracellular Volume ◽

Ventricular Myocardium ◽

Left Ventricular ◽

Healthy Adults ◽

Left Ventricular Myocardium ◽

3T Mri

Abstract purposeThe correlation between T1 and ECV value and myocardial fibrosis has been confirmed. In healthy adult, many disease may change T1 and ECV value. The purpose of this reseach is to clarify the T1 mapping and extracellular volume (ECV) value of healthy adults in 3 Tesla (T) magnetic resonance imaging (MRI), and to study the relationship between the values with age and gender.Methods We recruited 87 healthy adult subjects (mean age 38 ± 11 years; 61% were females) for cardiac magnetic resonance examination at 3T MRI. The left ventricular function parameters were obtained from functional imaging. T1 mapping was performed using an improved Look-Locker reversal recovery sequence after motion correction. resultsUnder 3T field strength, T1 value of the myocardium of healthy adults was 1,261 ± 52, and the ECV value was 28.3% ± 2.9%. T1 value and ECV values of female myocardium were higher than those of males (1,274 ± 56 vs. 1,241 ± 40, P = 0.003; 29.6% ± 2.6% vs. 26.2% ± 2.1%, P < 0.001). Only gender (Beta = 0.311, P = 0.003) was independently related to the native T1 mapping of left ventricular myocardium, while gender (Beta = 0.572, P < 0.001) and age (Beta = 0.501, P = 0.003) were related to the ECV value of left ventricular myocardium. T1 value (P = 0.002) and ECV value (P = 0.013) increased significantly from the base to the apex. There were significant differences in the T1 and ECV value between each segment (P < 0.001) in the base of the left ventricle. Significant differences were observed between the middle segments of T1 value (P = 0.001) but not between the middle of the ECV value of each segment (P = 0.068). Lastly, there was no statistical difference between each segment in the apical of the T1 (P = 0.756) and ECV value (P = 0.344).ConclusionsUnder 3T MRI, the T1 value of the myocardium of healthy adults was 1,261 ± 52, and the ECV value was 28.3% ± 2.9%. T1 and ECV values of females were significantly higher than those of males. The ECV values of males increased with age, while T1 value in males and T1 and ECV values in females had no significant relationship with age.

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P1195 Magnetic resonance imaging of targeted catheter-based implantation of myogenic precursor cells into infarcted left-ventricular myocardium

European Heart Journal ◽

10.1016/s0195-668x(03)94487-3 ◽

2003 ◽

Vol 24 (5) ◽

pp. 223

Author(s):

J GAROT

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Ventricular Myocardium ◽

Left Ventricular ◽

Precursor Cells ◽

Left Ventricular Myocardium ◽

Resonance Imaging ◽

Myogenic Precursor

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Effect of Valsartan on Sarcoplasmic Reticulum Ca2+-ATPase Pump of the Left Ventricular Myocardium in Rats with Heart Failure with Preserved Ejection Fraction

Biomedicine Hub ◽

10.1159/000448132 ◽

2016 ◽

Vol 1 (2) ◽

pp. 1-9

Author(s):

Xiao Ying ◽

Long Weiqing ◽

Lu Guihua ◽

Zhang Juhong ◽

Zhibin Huang

Keyword(s):

Heart Failure ◽

Ejection Fraction ◽

Diastolic Pressure ◽

Ventricular Myocardium ◽

Left Ventricular ◽

Left Ventricular Myocardium ◽

Preserved Ejection Fraction ◽

Relaxation Time Constant ◽

Ventricular Relaxation ◽

Constant Quantity

Objectives: The aim was to investigate the effects of valsartan on the sarcoplasmic reticulum Ca2+-ATPase pump (SERCA) and L-type Ca2+ channel current (ICaL) of the left ventricular myocardium in rats with heart failure with preserved ejection fraction. Methods: The 30-week-old male spontaneously hypertensive rats (SHRs) are randomly divided into the non-Valsartan and Valsartan groups, and the 30-week-old male Wistar-Kyoto rats served as control rats. The expression of SERCA is measured by Western blot. The ICaL is measured by whole-cell patch clamp. The left ventricular end-diastolic pressure and left ventricular relaxation time constant quantity are measured at the same time. Results: The left ventricular end-diastolic pressure is much higher in SHRs compared with that in control rats (p < 0.01). The left ventricular relaxation time constant quantity is markedly extended in SHRs compared with control rats (p < 0.01). Valsartan cannot increase the expression of SERCA nor decrease the density of ICaL compared with the non-Valsartan group (p > 0.05). Conclusions: Valsartan has no effect on SERCA and ICaL of the left ventricular myocardium in rats with heart failure with preserved ejection fraction.

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P6398Peculiarities of the dynamics of fibrosis markers at the in-hospital stage in myocardial infarction patients with preserved left ventricular ejection fraction

European Heart Journal ◽

10.1093/eurheartj/ehz746.0994 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

A V Osokina ◽

V N Karetnikova ◽

O M Polikutina ◽

Y U S Slepynina ◽

O V Gruzdeva ◽

...

Keyword(s):

Ejection Fraction ◽

Myocardial Contractility ◽

Myocardial Dysfunction ◽

Ventricular Myocardium ◽

Serum Markers ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

Control Group ◽

Left Ventricular Myocardium ◽

Ventricular Ejection Fraction

Abstract Purpose To identify the peculiarities of the dynamics of fibrosis markers in patients with STEMI and preserved myocardial contractility and to determine the relationship between the studied biomarkers and EchoCG indicators characterizing the violation of left ventricular myocardium diastolic function. Material and methods The study included 120 patients with STEMI. The final analysis included 83 patients with preserved left ventricular myocardial contractility measured. The preserved ejection fraction was considered to be ≥50%. Echocardiographic examination was performed using Sonos 2500. In addition to the standard laboratory and instrumental examinations, all the patients underwent the estimation of the concentrations of PICP and PIIINP by enzyme-linked immunoassay using BCM Diagnostics laboratory kits (USA) on the 1st and the 12th days of disease. To compare the obtained values of the studied markers, a control group of healthy volunteers matched by age and gender with the main sample of the patients, was recruited, n=20 (100%). In this group the following values were obtained: PIIINP 7.2 [6.8; 7.5] ng/ml, PICP 179.2 [163.5; 194.9] ng/ml. Statistical processing of the obtained data was performed using Statistica 6.0 software. Results The mean age of the patients was 58.8 years; LVEF was 59.0% [54; 62]. According to EchoCG data, LV dysfunction at normal dimensions was registered in 59 (72%) patients, dilatation – in 22 (27%) patients and regional contractility violation – in 43 (52.4%) cases. The increased values of Tei index 0.70 [0.63; 0.76] and myocardial mass 241.0 g [206.5; 272.0] stand out. The values of serum markers concentrations obtained on the 1st day of STEMI, significantly exceeded the values of the control group and were as follows: PIIINP 26.0 (18.9; 34.9) ng/ml (p=0.047), PICP – 609.0 (583.0; 635.0) ng/ml (p=0.049). On the 12th day the concentration of PICP - 588.0 (580.0; 621.0) ng/ml, PIIINP – 24.2 (18.6; 30.3) ng/ml. No statistically significant differences were obtained in comparison of the markers' concentrations on the 1st and 12th days of the disease. As a result of the correlation analysis between the values of the studied serum markers and EchoCG indicators the following statistically significant relationships were identified: E/Em the 1st day - PICP the 12th day: r=0.55, p=0.005; E/A the 12th day - PICP the 1st day: r=−0.42, p=0.033; E/Em the 12th day - PICP the 12th day: r=0.48, p=0.015; EDV the 12th day - PIIINP the 1st day: r=0.62, p=0.001; EDI the 12th day - PIIINP the 1st day: r=0.43, p=0.034; Age - PIIINP the 1st day: r=0.558, p=0.016. Conclusion The presence of statistically significant correlations between the concentrations of PIIINP, PICP with EchoCG indicators evidence the role of fibrosis in the formation of diastolic myocardial dysfunction and reflect the potential use of procollagen to predict heart failure in long-term post-infarction period.

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