scholarly journals Glomerular filtration (GF) determined by creatinine clearance (CCR) in 24 hours urine and cockcroft & gault (cg) and modification of diet in renal disease (MDRD) equations in a large cohort of HIV+ patients

Retrovirology ◽  
2010 ◽  
Vol 7 (S1) ◽  
Author(s):  
Pablo Labarga ◽  
Marta Albalate ◽  
Pablo Barreiro ◽  
Elena Alvarez ◽  
Luz Martín-Carbonero ◽  
...  
Keyword(s):  
Renal Disease ◽  
Creatinine Clearance ◽  
Glomerular Filtration ◽  
Large Cohort ◽  
Hiv Patients

scholarly journals Comparison of Measured Creatinine Clearance and Clearances Estimated by Cockcroft-Gault and MDRD Formulas in Patients with a Single Kidney

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Sebastião Rodrigues Ferreira-Filho ◽  
Camila Caetano Cardoso ◽  
Luiz Augusto Vieira de Castro ◽  
Ricardo Mendes Oliveira ◽  
Renata Rodrigues Sá
Keyword(s):  
Glomerular Filtration Rate ◽  
Renal Disease ◽  
Creatinine Clearance ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Urine Collection ◽  
Strongly Correlated ◽  
Rate Estimation ◽  
Glomerular Filtration Rate Estimation ◽  
Single Kidney

There are doubts about whether the values obtained from the Cockroft-Gault (ClCG) and Modification of Diet in Renal Disease (GFRMDRD) formulas are comparable to the more traditional formula used to obtain the creatinine clearance from a 24-hour urine collection (ClCrm), particularly in patients with only one kidney. The present study aimed to compare these formulas in individuals with one remaining kidney after previous nephrectomy (Nx) and to verify which estimated formula correlates more closely with ClCrm. Thirty-six patients who had undergone Nx had their renal filtration analyzed with ClCG, GFRMDRDand by ClCrm. The average time after Nx was years, and the average age at the time of the study was years old (X ± SD). The results of three clearances were  mL·min·m2for ClCrm, mL·min·m2for ClCrCG, and mL·min·m2for GFRMDRD(with ClCrm> ClCrCGand GFRMDRD; ). No difference was found between the ClCrCGand GFRMDRDvalues (). The data demonstrated that both estimate formulas were strongly correlated with ClCrm, although ClCrCGwas more closely associated with ClCrmthan GFRMDRD(ClCrCGwith and GFRMDRDwith ; ). In conclusion, for people with only one kidney remaining after NX, our data showed that glomerular filtration rate estimation by ClCrCGis more related to the values obtained with the traditional clearance measurement based on a 24-hour urine collection test.

scholarly journals Prospective Comparison of 24-Hour Urine Creatinine Clearance with Estimated Glomerular Filtration Rates in Chronic Renal Disease Patients of African Descent

Medicines ◽  
2021 ◽  
Vol 8 (9) ◽  
pp. 48
Author(s):  
Marlene Tapper ◽  
Donovan A. McGrowder ◽  
Lowell Dilworth ◽  
Adedamola Soyibo
Keyword(s):  
Renal Disease ◽  
Creatinine Clearance ◽  
Glomerular Filtration ◽  
Chronic Renal Disease ◽  
Correlation Coefficients ◽  
Stage Iv ◽  
Disease Epidemiology ◽  
Mdrd Equation ◽  
Prospective Comparison ◽  
A Prospective Study

Background: The 24-hour (24-h) creatinine clearance (CrCl) is the most common method for measuring GFR in clinical laboratories. However, the limitations of CrCl have resulted in the widespread acceptance of mathematically derived estimated glomerular filtration rate (eGFR) using Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD) and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations in predicting eGFR. The aim of the study was to compare 24-h CrCl with eGFR derived from these formulae and to identify which could be the best alternative. Method: A prospective study was conducted involving 140 CKD patients. Creatinine and cystatin C concentrations were determined using the cobas 6000 analyzer. The eGFR was calculated using the CG formula, 4-variable MDRD and CKD-EPI equations, and Bland-Alman plots bias was determined. Results: The CG and MDRD formulas had mean eGFR values similar to CrCl and correlation coefficients (r) were highest for CG (0.906) and lowest for MDRD (0.799). The CG equation was in agreement with 24-h CrCl in all but stage V CKD while the MDRD equation compared well in all except Stage IV CKD. The CG equation was positively biased (0.9857) while the MDRD had a negative bias (−0.05). Conclusion: The Cockcroft-Gault formula provides a more accurate assessment of GFR than 24-h CrCl and would be recommended as a substitute to provide the best estimate of GFR in our population.

Predicted Creatinine Clearance to Assess Glomerular Filtration Rate in Chronic Renal Disease in Humans

1991 ◽  
Vol 11 (3) ◽  
pp. 181-185 ◽  
Author(s):  
Natale G. DeSanto ◽  
Salvatore Coppola ◽  
Pietro Anastasio ◽  
Giuliana Coscarella ◽  
Giovambattista Capasso ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Renal Disease ◽  
Creatinine Clearance ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Chronic Renal Disease

Simultaneous Iothalamate, Creatinine, and Urea Clearances in Children With Renal Disease

PEDIATRICS ◽  
1977 ◽  
Vol 59 (2) ◽  
pp. 219-223 ◽  
Author(s):  
Ben H. Brouhard ◽  
Luther B. Travis ◽  
Robert J. Cunningham ◽  
Michael Berger ◽  
Hugo F. Carvajal
Keyword(s):  
Glomerular Filtration Rate ◽  
Renal Disease ◽  
Creatinine Clearance ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Clinical Tool ◽  
The Mean ◽  
Low Levels

Glomerular filtration rate (GFR) is often used to evaluate and manage patients with renal disease. Few studies in children have compared accurate estimations of GFR (clearance of inulin and/or iothalamate) with the clearance of creatinine which, because of simplicity, has been used as an approximation of GFR. At reduced levels of GFR, studies in adults suggest that the mean of the creatinine and urea clearances closely approximate the GFR. The present investigation shows that the clearance of creatinine approximates the GFR at normal levels; however, at reduced levels the creatinine clearance and the mean of the creatinine and urea clearances both overestimate the GFR as measured by iothalamate. The clearance of creatinine remains a useful clinical tool if its limitations at low levels of GFR are realized.

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