scholarly journals Host cell species-specific effect of cyclosporine A on simian immunodeficiency virus replication

Retrovirology ◽  
2012 ◽  
Vol 9 (1) ◽  
Author(s):  
Hiroaki Takeuchi ◽  
Hiroshi Ishii ◽  
Tetsuya Kuwano ◽  
Natsuko Inagaki ◽  
Hirofumi Akari ◽  
...  
Keyword(s):  
Host Cell ◽  
Simian Immunodeficiency Virus ◽  
Virus Replication ◽  
Cyclosporine A ◽  
Specific Effect ◽  
Immunodeficiency Virus ◽  
Species Specific

scholarly journals Cross-protection against mucosal simian immunodeficiency virus (SIVsm) challenge in human immunodeficiency virus type 2-vaccinated cynomolgus monkeys

2001 ◽  
Vol 82 (7) ◽  
pp. 1601-1612 ◽  
Author(s):  
Lilian Walther-Jallow ◽  
Charlotta Nilsson ◽  
Johan Söderlund ◽  
Peter ten Haaft ◽  
Barbro Mäkitalo ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Simian Immunodeficiency Virus ◽  
Virus Replication ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Cross Protection ◽  
Parallel Group ◽  
Immunodeficiency Virus ◽  
Siv Infection

In this study we compared the efficacy of live attenuated human immunodeficiency virus type 2 (HIV-2) vaccine alone versus boosting with live non-pathogenic HIV-2 following priming with ALVAC HIV-2 (recombinant canarypox virus expressing HIV-2 env, gag and pol). Six monkeys were first inoculated intravenously with live HIV-2SBL-6669 and 7 to 10 months later were challenged intrarectally with 10 MID50 of cell-free simian immunodeficiency virus (SIV) strain SIVsm. One monkey was completely protected against SIV infection and all five monkeys that became SIV-infected showed a lower virus replication and an initial lower virus load as compared with a parallel group of six control animals. In another experiment five monkeys were immunized either three times with ALVAC HIV-2 alone or twice with ALVAC HIV-2 and once with purified native HIV-2 gp125. The monkeys were then challenged with HIV-2 given intravenously and finally with pathogenic SIVsm given intrarectally. After challenge with SIVsm, three of five monkeys were completely protected against SIVsm infection whereas the remaining two macaques became SIV-infected but with limited virus replication. In conclusion, vaccination with an ALVAC HIV-2 vaccine followed by exposure to live HIV-2 could induce cross-protection against mucosal infection with SIVsm and seemed to be more efficient than immunization with a live HIV-2 vaccine only.

scholarly journals The Susceptibility of Primate Lentiviruses to Nucleosides and Vpx during Infection of Dendritic Cells Is Regulated by CA

2015 ◽  
Vol 89 (7) ◽  
pp. 4030-4034 ◽  
Author(s):  
Véronique Barateau ◽  
Xuan-Nhi Nguyen ◽  
Fanny Bourguillault ◽  
Grégory Berger ◽  
Stéphanie Cordeil ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Dendritic Cells ◽  
Simian Immunodeficiency Virus ◽  
Viral Protein ◽  
Immunodeficiency Virus ◽  
Protein X ◽  
Primate Lentiviruses ◽  
Species Specific ◽  
Hiv 1

The block toward human immunodeficiency virus type 1 (HIV-1) infection of dendritic cells (DCs) can be relieved by Vpx (viral protein X), which degrades sterile alpha motif-hydroxylase domain 1 (SAMHD1) or by exogenously added deoxynucleosides (dNs), lending support to the hypothesis that SAMHD1 acts by limiting deoxynucleoside triphosphates (dNTPs). This notion has, however, been questioned. We show that while dNs and Vpx increase the infectivity of HIV-1, only the latter restores the infectivity of a simian immunodeficiency virus of macaques variant, SIVMACΔVpx virus. This distinct behavior seems to map to CA, suggesting that species-specific CA interactors modulate infection of DCs.

scholarly journals Neuroinflammation and Virus Replication in the Spinal Cord of Simian Immunodeficiency Virus–Infected Macaques

2015 ◽  
Vol 74 (1) ◽  
pp. 38-47 ◽  
Author(s):  
Lisa M. Mangus ◽  
Jamie L. Dorsey ◽  
Victoria A. Laast ◽  
Peter Hauer ◽  
Suzanne E. Queen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Simian Immunodeficiency Virus ◽  
Virus Replication ◽  
Immunodeficiency Virus

scholarly journals Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques

2017 ◽  
Vol 13 (7) ◽  
pp. e1006529 ◽  
Author(s):  
Mauricio A. Martins ◽  
Young C. Shin ◽  
Lucas Gonzalez-Nieto ◽  
Aline Domingues ◽  
Martin J. Gutman ◽  
...  
Keyword(s):  
Immune Responses ◽  
Simian Immunodeficiency Virus ◽  
Virus Replication ◽  
Rhesus Macaques ◽  
Immunodeficiency Virus

scholarly journals Natural killer cells migrate into and control simian immunodeficiency virus replication in lymph node follicles in African green monkeys

2017 ◽  
Vol 23 (11) ◽  
pp. 1277-1286 ◽  
Author(s):  
Nicolas Huot ◽  
Beatrice Jacquelin ◽  
Thalia Garcia-Tellez ◽  
Philippe Rascle ◽  
Mickaël J Ploquin ◽  
...  
Keyword(s):  
Lymph Node ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Simian Immunodeficiency Virus ◽  
Virus Replication ◽  
Killer Cells ◽  
Immunodeficiency Virus ◽  
And Control ◽  
Green Monkeys

Recombinant human CD40 ligand inhibits simian immunodeficiency virus replication: A role for interleukin-16

1999 ◽  
Vol 28 (4-5) ◽  
pp. 190-194 ◽  
Author(s):  
Mark E. Lee ◽  
Silvana Z. Bucur ◽  
Theresa W. Gillespie ◽  
Jonathan W. Adams ◽  
Andrew T. Barker ◽  
...  
Keyword(s):  
Simian Immunodeficiency Virus ◽  
Virus Replication ◽  
Cd40 Ligand ◽  
Immunodeficiency Virus

scholarly journals miR-190b Is Markedly Upregulated in the Intestine in Response to Simian Immunodeficiency Virus Replication and Partly Regulates Myotubularin-Related Protein-6 Expression

2014 ◽  
Vol 193 (3) ◽  
pp. 1301-1313 ◽  
Author(s):  
Mahesh Mohan ◽  
Lawrance C. Chandra ◽  
Workineh Torben ◽  
Pyone P. Aye ◽  
Xavier Alvarez ◽  
...  
Keyword(s):  
Simian Immunodeficiency Virus ◽  
Virus Replication ◽  
Related Protein ◽  
Immunodeficiency Virus
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