scholarly journals Hepatitis B virus (HBV) genotypes in Egyptian pediatric cancer patients with acute and chronic active HBV infection

2007 ◽  
Vol 4 (1) ◽  
pp. 74 ◽  
Author(s):  
Abdel-Rahman N Zekri ◽  
Mohamed M Hafez ◽  
Nahed I Mohamed ◽  
Zeinab K Hassan ◽  
Manal H El-Sayed ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Hbv Infection ◽  
Hbv Genotypes ◽  
Pediatric Cancer Patients ◽  
B Virus

Prevalence and genotyping of hepatitis B virus: a cross-sectional study conducted with female sex workers in the Marajó Archipelago, Brazil

2019 ◽  
Vol 30 (9) ◽  
pp. 902-910 ◽  
Author(s):  
Paula CR Frade ◽  
Nairis C Raiol ◽  
Luana M da Costa ◽  
Luiz ML Pinheiro ◽  
Gláucia C Silva-Oliveira ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Sex Workers ◽  
Female Sex Workers ◽  
Hbv Infection ◽  
Enzyme Linked Immunosorbent Assay ◽  
Hepatitis D ◽  
Female Sex ◽  
Hbv Genotypes ◽  
B Virus

In South America, the Amazon basin is considered an endemic area of hepatitis B virus (HBV) infection. However, epidemiological studies with vulnerable groups are scarce. Female sex workers (FSWs) are highly vulnerable to sexually transmitted infections due to a combination of their sexual behavior and socio-economic conditions. Thus, this study investigated the prevalence of HBV infections and HBV–hepatitis C virus, HBV–hepatitis D virus, HBV–HIV, and HBV–human T-lymphotropic virus co-infections among FSWs in the Marajó Archipelago, northern Brazil, as well as identifying the HBV genotypes circulating in this population. A total of 153 FSWs in 5 towns and 18 riverside communities were included in the study. The HBV infection and co-infections were diagnosed by enzyme-linked immunosorbent assay and real-time polymerase chain reaction. The HBV genotypes were detected by sequencing and were then analyzed phylogenetically. Most of the FSWs surveyed were single, young, heterosexual, and born locally, with low levels of education. Overall, 21 (13.7%) had been exposed to HBV, and HBV-DNA was detected in 13 (8.5%). Genotypes A (69.2%), D (23.1%), and F (7.7%) were detected. Seven cases of co-infections with other viruses were detected. These findings indicate a clear need for urgent measures to control the spread of HBV and other pathogens, and to promote the health of the local FSWs.

Molecular Epidemiology of Hepatitis B Virus (HBV) Genotypes and Serotypes in Patients with Chronic HBV Infection in Korea

Intervirology ◽  
2006 ◽  
Vol 50 (1) ◽  
pp. 52-57 ◽  
Author(s):  
Hong Kim ◽  
Young Mee Jee ◽  
Byung-Cheol Song ◽  
Jung Woo Shin ◽  
Soo Hyun Yang ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Molecular Epidemiology ◽  
Hbv Infection ◽  
Chronic Hbv Infection ◽  
Hbv Genotypes ◽  
B Virus ◽  
Chronic Hbv

Clinical outcomes of hepatitis B virus (HBV) genotypes B and C in Japanese patients with chronic HBV infection.

2002 ◽  
Vol 67 (2) ◽  
pp. 151-157 ◽  
Author(s):  
Norihiro Furusyo ◽  
Seizaburo Kashiwagi ◽  
Kenichiro Kashiwagi ◽  
Kazuhiro Hayashida ◽  
Jun Hayashi ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Clinical Outcomes ◽  
Japanese Patients ◽  
Hbv Infection ◽  
Chronic Hbv Infection ◽  
Hbv Genotypes ◽  
B Virus ◽  
Chronic Hbv

scholarly journals African, Amerindian and European hepatitis B virus strains circulate on the Caribbean Island of Martinique

2013 ◽  
Vol 94 (10) ◽  
pp. 2318-2329 ◽  
Author(s):  
Ségolène Brichler ◽  
Gisèle Lagathu ◽  
Mariama Abdou Chekaraou ◽  
Frédéric Le Gal ◽  
André Edouard ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Slave Trade ◽  
Direct Sequencing ◽  
Phylogenetic Analyses ◽  
West African ◽  
Hbv Infection ◽  
Genotype Distribution ◽  
Hbv Genotypes ◽  
B Virus

Ten Hepatitis B virus (HBV) genotypes, as well as numerous subgenotypes, have been described in well-characterized ethnogeographical populations. Martinique has been at a crossroads between Africa, Europe, India and the Americas because of the slave trade (17th–19th centuries), followed by an important immigration of Indian and West African workers. In this work, we aimed to study the molecular epidemiology of HBV infection in Martinique according to this unique settlement pattern. To that end, blood samples from 86 consecutive HBV-infected patients from the main hospitals of the island, were retrospectively analysed. Direct sequencing of the pre-S1 or pre-C-C region or complete genome sequencing, followed by phylogenetic analyses were performed. HBV genotypes were: HBV/A1 (68.6 %), HBV/A2 (10.5 %), HBV/D, mainly HBV/D3 and HBV/D4 (8.1 %), HBV/F (3.5 %), and also HBV/E (2.3 %), two strains isolated from two West-African patients. Moreover, 74 % of the HBeAg-negative strains harboured classical pre-C-C mutations, and most HBV/A1 strains also containing specific mutations. Finally, various patterns of deletion mutants in pre-S and pre-C-C regions were found. In conclusion, our findings point to historical and migration-related issues in HBV-genotype distribution suggesting that HBV/A1, but not HBV/E, was imported from Africa during the slave trade, and further supporting the hypothesis that HBV/E has emerged recently in West Africa (<150 years). Potential origins of ‘European’ HBV/A2 and HBV/D3, ‘Amerindian’ HBV/F, and HBV/D4 strains are also discussed. Such HBV genetic diversity, beyond its epidemiological interest, may have a clinical impact on the natural history of HBV infection in Martinique.

Study of hepatitis B virus (HBV) genotypes in families of patients with chronic HBV infection: comparison of asian and ocidental origin people in Brazil

2002 ◽  
Vol 36 ◽  
pp. 221-222
Author(s):  
C.M. Clemente ◽  
F.J. Carrilho ◽  
S.K. Ono-Nita ◽  
M.F. Lemos ◽  
I.M.V.G.C. Mello ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hbv Infection ◽  
Chronic Hbv Infection ◽  
Hbv Genotypes ◽  
B Virus ◽  
Chronic Hbv

scholarly journals Epidemiological and Clinical Features of Hepatitis B Virus Genotypes among Immigrants in Southern Italy

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Gaetano Scotto ◽  
Domenico Martinelli ◽  
Rocco Di Tullio ◽  
Vincenzina Fazio
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Clinical Features ◽  
Hbv Dna ◽  
Hbv Infection ◽  
Hbv Genotypes ◽  
B Virus ◽  
Virus Genotypes ◽  
Severe Chronic Hepatitis

Background/aims. This study aims to determine the distribution and clinical features of HBV-genotypes in a population of immigrants affected by HBV-infection. Methods. Between 01/2003 and 03/2009, 1623 immigrants were tested for HBV-infection. Biochemical and virological activities were determined in HBsAg-positive patients; HBV-genotypes were determined, by the INNO-LiPA HBV Genotyping, in the subjects with HBV DNA detectable. In every patient we evaluated the stage and classified the infection as inactive carrier, mild or moderate/severe chronic hepatitis, cirrhosis, and/or HCC. Results. Among the tested subjects, 191 (11.7%) resulted HBsAg-positive, and in 144/191 (75.4%) serum HBV-DNA was detectable. The genotype distribution was as follows: 45,13% genotype E, 18,1% genotype D, 15,3% genotype B, 13,2% genotype C, 4,9% genotype A, 3,5% mixed genotypes (A–D). The evaluation of liver disease degree showed that 24.6% patients were inactive carriers of HBV infection, 19.4% presented a immunotolerance phase, 34.5% had mild chronic hepatitis, 13.6% had a moderate/severe chronic hepatitis, 6.3% had cirrhosis, and 1.6% presented HCC. Conclusions. Our study evidences a high prevalence of HBV-infection in immigrants, and the potentiality of migratory flow in the introduction of genotype non-D hepatitis B virus. The Hepatitis B virus genotypes presented significant differences in epidemiological and clinical characteristics.

scholarly journals A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide

2015 ◽  
Vol 89 (23) ◽  
pp. 11945-11953 ◽  
Author(s):  
Manabu Kaneko ◽  
Koichi Watashi ◽  
Shinji Kamisuki ◽  
Hiroki Matsunaga ◽  
Masashi Iwamoto ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Sodium Taurocholate ◽  
Hbv Infection ◽  
Chemical Library ◽  
Hepatitis D ◽  
Active Inhibitor ◽  
Hepatitis D Virus ◽  
Hbv Genotypes ◽  
B Virus

ABSTRACTAnti-hepatitis B virus (HBV) drugs are currently limited to nucleos(t)ide analogs (NAs) and interferons. A challenge of drug development is the identification of small molecules that suppress HBV infection from new chemical sources. Here, from a fungus-derived secondary metabolite library, we identify a structurally novel tricyclic polyketide, named vanitaracin A, which specifically inhibits HBV infection. Vanitaracin A inhibited the viral entry process with a submicromolar 50% inhibitory concentration (IC50) (IC50= 0.61 ± 0.23 μM), without evident cytotoxicity (50% cytotoxic concentration of >256 μM; selectivity index value of >419) in primary human hepatocytes. Vanitaracin A did not affect the HBV replication process. This compound was found to directly interact with the HBV entry receptor sodium taurocholate cotransporting polypeptide (NTCP) and impaired its bile acid transport activity. Consistent with this NTCP targeting, antiviral activity of vanitaracin A was observed with hepatitis D virus (HDV) but not hepatitis C virus. Importantly, vanitaracin A inhibited infection by all HBV genotypes tested (genotypes A to D) and clinically relevant NA-resistant HBV isolate. Thus, we identified a fungal metabolite, vanitaracin A, which was a potent, well-tolerated, and broadly active inhibitor of HBV and HDV entry. This compound, or its related analogs, could be part of an antiviral strategy for preventing reinfection with HBV, including clinically relevant nucleos(t)ide analog-resistant virus.IMPORTANCEFor achieving better treatment and prevention of hepatitis B virus (HBV) infection, anti-HBV agents targeting a new molecule are in great demand. Although sodium taurocholate cotransporting polypeptide (NTCP) has recently been reported to be an essential host factor for HBV entry, there is a limited number of reports that identify new compounds targeting NTCP and inhibiting HBV entry. Here, from an uncharacterized chemical library, we isolated a structurally new compound, named vanitaracin A, which inhibited the process of entry of HBV and hepatitis D virus (HDV). This compound was suggested to directly interact with NTCP and inhibit its transporter activity. Importantly, vanitaracin A inhibited the entry of all HBV genotypes examined and of a clinically relevant nucleos(t)ide analog-resistant HBV isolate.

Long-term follow-up of a Japanese patient with hepatitis B virus genotype H and human immunodeficiency virus coinfection

2019 ◽  
Vol 14 (10) ◽  
pp. 633-639 ◽  
Author(s):  
Masahiro Ogawa ◽  
Shinya Kamimura ◽  
Tatsuo Kanda ◽  
Hiroshi Takahashi ◽  
Taku Mizutani ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Highly Active Antiretroviral Therapy ◽  
Hbv Infection ◽  
Virus Genotype ◽  
Hbv Genotype ◽  
Hbv Genotypes ◽  
Highly Active ◽  
B Virus ◽  
Long Term Follow Up

Hepatitis B virus (HBV) genotypes affect the pathogenesis of disease progression during the course of HBV infection. In Japan, HBV genotype H is one of the rare HBV genotypes. We recovered HBV genotype H from a blood sample from a Japanese HIV-infected patient with acute exacerbation of chronic HBV infection. Due to the development of drugs for treating HBV and HIV, HBV genotype H and HIV coinfection has been well controlled by nucleos(t)ide analogs and highly active antiretroviral therapy, respectively, from 2002 to 2019. Further study is needed with regard to HBV genotype H and its pathogenesis.

Sign in / Sign up

Export Citation Format

Share Document