scholarly journals PreS1 epitope recognition in newborns after vaccination with the third-generation Sci-B-Vac™ vaccine and their relation to the antibody response to hepatitis B surface antigen

2009 ◽  
Vol 6 (1) ◽  
pp. 7 ◽  
Author(s):  
Ulla B Hellström ◽  
Kazimierz Madalinski ◽  
Staffan PE Sylvan
Author(s):  
C.R.B. Ferreira ◽  
C.F.T. Yoshida ◽  
L.A.C. Mercadante ◽  
D.F. Gomes ◽  
J.M. Oliveira ◽  
...  

A previous seroepidemiological study in the rural zone of Vargem Alta (ES) SouthEast of Brazil, showed a prevalence of up to 9% of hepatitis B surface antigen (HBsAg) in some areas. One hundred susceptible children aging 1 to 5 years old were selected and immunized with a recombinant DNA hepatitis B vaccine (Smith-Kline 20 mcg) using the 0-1-6 months vaccination schedule. Blood samples were collected at the time of the first vaccine dose (month 0) in order to confirm susceptible individuals and 1,3,6 and 8 months after the first dose , to evaluate the antibody response. Our results showed that two and five months after the second dose, 79% and 88% of children seroconverted respectively, reaching 97% after the third dose. The levels of anti-HBs were calculated in milli International Units/ml (mIU/ml) and demonstrated the markedly increase of protective levels of antibodies after the third dose. These data showed a good immunogenicity of the DNA recombinant hepatitis B vaccine when administered in children of endemic areas.


Vaccine ◽  
2019 ◽  
Vol 37 (40) ◽  
pp. 5954-5961 ◽  
Author(s):  
Thuy Trang Nguyen ◽  
Jung-ah Choi ◽  
Ji Seok Kim ◽  
Hayan Park ◽  
Eunji Yang ◽  
...  

BMJ ◽  
1985 ◽  
Vol 291 (6498) ◽  
pp. 780-782 ◽  
Author(s):  
P Wantzin ◽  
J O Nielsen ◽  
N Tygstrup ◽  
H Soerensen ◽  
E Dybkjaer

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